Reply to Skokou, M. Comment on “Keeler et al. Ketamine as a Treatment for Anorexia Nervosa: A Narrative Review. Nutrients 2021, 13, 4158”

Keeler, Johanna Louise; Treasure, Janet; Juruena, Mário F.; Kan, Carol; Himmerich, Hubertus

doi:10.3390/nu14102119

Cited by 3 publications

(2 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 50 , 51 Patients with AN are thought to have chronic low-grade inflammation of unknown origin (meta-analysis by 52 ); however, recent findings are more diverse and show variable dysregulation of the immunologic state. 53 , 54 AN is also associated with an increased rate of autoimmune diseases, especially Crohn’s disease and celiac disease. 55 , 56 Therefore, the immunomodulatory effects of these taxa might be important for their mechanistic role in AN outcomes.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal analysis of the gut microbiome in adolescent patients with anorexia nervosa: microbiome-related factors associated with clinical outcome

Andreani,

Sharma,

Dahmen

et al. 2024

Gut Microbes

View full text Add to dashboard Cite

There is mounting evidence regarding the role of gut microbiota in anorexia nervosa (AN). Previous studies have reported that patients with AN show dysbiosis compared to healthy controls (HCs); however, the underlying mechanisms are unclear, and data on influencing factors and longitudinal course of microbiome changes are scarce. Here, we present longitudinal data of 57 adolescent inpatients diagnosed with AN at up to nine time points (including a 1-year follow-up examination) and compare these to up to six time points in 34 HCs. 16S rRNA gene sequencing was used to investigate the microbiome composition of fecal samples, and data on food intake, weight change, hormonal recovery (leptin levels), and clinical outcomes were recorded. Differences in microbiome composition compared to HCs were greatest during acute starvation and in the low-weight group, while diminishing with weight gain and especially weight recovery at the 1-year follow-up. Illness duration and prior weight loss were strongly associated with microbiome composition at hospital admission, whereas microbial changes during treatment were associated with kilocalories consumed, weight gain, and hormonal recovery. The microbiome at admission was prognostic for hospital readmission, and a higher abundance of Sutterella was associated with a higher body weight at the 1-year follow-up. Identifying these clinically important factors further underlines the potential relevance of gut microbial changes and may help elucidate the underlying pathophysiology of gut-brain interactions in AN. The characterization of prognostically relevant taxa could be useful to stratify patients at admission and to potentially identify candidate taxa for future supplementation studies aimed at improving AN treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Longitudinal analysis of the gut microbiome in adolescent patients with anorexia nervosa: microbiome-related factors associated with clinical outcome

Andreani,

Sharma,

Dahmen

et al. 2024

Gut Microbes

View full text Add to dashboard Cite

show abstract

“…Decreased Lachnospiraceae is a well-accepted marker of inflammation in several inflammatory disorders (Geirnaert et al, 2017;Maukonen & Ouwehand, 2022). Patients with AN are thought to have chronic low-grade inflammation of unknown origin (meta-analysis by (Dalton et al, 2018)); however, recent findings are more diverse and show variable dysregulation of the immunologic state (Keeler et al, 2022;Schulz et al, 2021). AN is also associated with an increased rate of autoimmune diseases, especially Crohn's disease and celiac disease (Hedman et al, 2019;Raevuori et al, 2014).…”

Section: Prognostic Relevance Of Baseline Microbiome For Clinical Out...mentioning

confidence: 99%

Longitudinal analysis of the gut microbiome in adolescent patients with anorexia nervosa: microbiome-related factors associated with clinical outcome

Andreani¹,

Sharma²,

Dahmen³

et al. 2023

Preprint

View full text Add to dashboard Cite

There is mounting evidence about the role of gut microbiota in anorexia nervosa (AN). Previous studies reported patients with AN to show dysbiosis compared to healthy controls (HCs), however, underlying mechanisms are unclear and data on influencing factors and the longitudinal course of microbiome changes are scarce. Here we present longitudinal data of 57 adolescent inpatients diagnosed with AN at up to nine timepoints (including 1-year follow-up examination) and compare these to up to six timepoints in 34 HCs. 16S rRNA gene sequencing was used to investigate the microbiome composition of fecal samples, while data on food intake, weight change, hormonal recovery (leptin levels) and clinical outcome were recorded. Differences in the microbiome composition compared to HCs were greatest during acute starvation and in the low-weight group, while diminishing with weight gain and especially weight recovery at 1-year follow-up. Illness duration and prior weight loss were strongly associated with microbiome composition at hospital admission, while microbial changes during treatment were associated with kilocalories consumed, weight gain and hormonal recovery. The microbiome at admission was prognostic for hospital readmission and a higher abundance of Sutterella was associated with higher body weight at 1-year follow-up. Identifying these clinically important factors further underlines the potential relevance of gut microbial changes and may help elucidate the underlying pathophysiology of gut-brain interaction in AN. The characterization of prognostically relevant taxa could be useful to stratify patients at admission and to potentially identify candidate taxa for future supplementation studies aimed at improving AN-treatment.

show abstract

The multisensory mind: a systematic review of multisensory integration processing in Anorexia and Bulimia Nervosa

Brizzi,

Sansoni,

Di Lernia

et al. 2023

J Eat Disord

View full text Add to dashboard Cite

Individuals with Anorexia Nervosa and Bulimia Nervosa present alterations in the way they experience their bodies. Body experience results from a multisensory integration process in which information from different sensory domains and spatial reference frames is combined into a coherent percept. Given the critical role of the body in the onset and maintenance of both Anorexia Nervosa and Bulimia Nervosa, we conducted a systematic review to examine multisensory integration abilities of individuals affected by these two conditions and investigate whether they exhibit impairments in crossmodal integration. We searched for studies evaluating crossmodal integration in individuals with a current diagnosis of Anorexia Nervosa and Bulimia Nervosa as compared to healthy individuals from both behavioral and neurobiological perspectives. A search of PubMed, PsycINFO, and Web of Sciences databases was performed to extract relevant articles. Of the 2348 studies retrieved, 911 were unique articles. After the screening, 13 articles were included. Studies revealed multisensory integration abnormalities in patients affected by Anorexia Nervosa; only one included individuals with Bulimia Nervosa and observed less severe impairments compared to healthy controls. Overall, results seemed to support the presence of multisensory deficits in Anorexia Nervosa, especially when integrating interoceptive and exteroceptive information. We proposed the Predictive Coding framework for understanding our findings and suggested future lines of investigation.

show abstract

Reply to Skokou, M. Comment on “Keeler et al. Ketamine as a Treatment for Anorexia Nervosa: A Narrative Review. Nutrients 2021, 13, 4158”

Abstract: In response to our narrative review, which suggested the use of the glutamatergic n-methyl-D-aspartate (NMDA) receptor antagonist ketamine as a potential treatment for anorexia nervosa (AN) [...]

Cited by 3 publications

References 22 publications

Longitudinal analysis of the gut microbiome in adolescent patients with anorexia nervosa: microbiome-related factors associated with clinical outcome

Longitudinal analysis of the gut microbiome in adolescent patients with anorexia nervosa: microbiome-related factors associated with clinical outcome

Longitudinal analysis of the gut microbiome in adolescent patients with anorexia nervosa: microbiome-related factors associated with clinical outcome

The multisensory mind: a systematic review of multisensory integration processing in Anorexia and Bulimia Nervosa

Contact Info

Product

Resources

About