Reply to Masin et al: To be or not to be a phospholipase A

Ostolaza, Helena

doi:10.1073/pnas.1801017115

Cited by 1 publication

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ostolaza et al suggest that CyaA-PLA acts to remodel the host cell membrane (releasing membrane fatty acids and lysophospholipids), generating a "toroidal pore" that facilitates transport of the AC domain (Ostolaza et al 2017). However, whether CyaA itself, and not an E. coli-derived contaminant, possesses PLA activity has been contested (Masin et al 2018;Ostolaza 2018), hence more studies are required to elucidate the contribution of PLA activity to CyaA biology. Translocation of the AC domain is concomitant with Ca 2+ influx in the host cell (Fiser et al 2007).…”

Section: Role In Infection and Disease Pathogenesismentioning

confidence: 99%

Role of Major Toxin Virulence Factors in Pertussis Infection and Disease Pathogenesis

Scanlon

Skerry

Carbonetti

2019

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

Bordetella pertussis produces several toxins that affect host-pathogen interactions. Of these, the major toxins that contribute to pertussis infection and disease are pertussis toxin, adenylate cyclase toxin-hemolysin and tracheal cytotoxin. Pertussis toxin is a multi-subunit protein toxin that inhibits host G protein-coupled receptor signaling, causing a wide array of effects on the host. Adenylate cyclase toxin-hemolysin is a single polypeptide, containing an adenylate cyclase enzymatic domain coupled to a hemolysin domain, that primarily targets phagocytic cells to inhibit their antibacterial activities. Tracheal cytotoxin is a fragment of peptidoglycan released by B. pertussis that elicits damaging inflammatory responses in host cells. This chapter describes these three virulence factors of B. pertussis, summarizing background information and focusing on the role of each toxin in infection and disease pathogenesis, as well as their role in pertussis vaccination.

show abstract

Section: Role In Infection and Disease Pathogenesismentioning

confidence: 99%