2018
DOI: 10.1073/pnas.1801017115
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Reply to Masin et al: To be or not to be a phospholipase A

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“…Ostolaza et al suggest that CyaA-PLA acts to remodel the host cell membrane (releasing membrane fatty acids and lysophospholipids), generating a "toroidal pore" that facilitates transport of the AC domain (Ostolaza et al 2017). However, whether CyaA itself, and not an E. coli-derived contaminant, possesses PLA activity has been contested (Masin et al 2018;Ostolaza 2018), hence more studies are required to elucidate the contribution of PLA activity to CyaA biology. Translocation of the AC domain is concomitant with Ca 2+ influx in the host cell (Fiser et al 2007).…”
Section: Role In Infection and Disease Pathogenesismentioning
confidence: 99%
“…Ostolaza et al suggest that CyaA-PLA acts to remodel the host cell membrane (releasing membrane fatty acids and lysophospholipids), generating a "toroidal pore" that facilitates transport of the AC domain (Ostolaza et al 2017). However, whether CyaA itself, and not an E. coli-derived contaminant, possesses PLA activity has been contested (Masin et al 2018;Ostolaza 2018), hence more studies are required to elucidate the contribution of PLA activity to CyaA biology. Translocation of the AC domain is concomitant with Ca 2+ influx in the host cell (Fiser et al 2007).…”
Section: Role In Infection and Disease Pathogenesismentioning
confidence: 99%