Reply to Marino et al. Choroidal Thickness Measurements in the Case of Diabetic Macular Edema. Comment on “Amjad et al. Choroidal Thickness in Different Patterns of Diabetic Macular Edema. J. Clin. Med. 2022, 11, 6169”

Amjad, Rida; Lee, Cheong-Ah; Farooqi, Hafiz Muhammad Umer; Khan, Hina; Paeng, Dong‐Guk

doi:10.3390/jcm12082877

Cited by 1 publication

(2 citation statements)

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“…OOC models can be utilized to study the absorption, distribution, metabolism, and excretion (ADME) properties of nutraceuticals. This information aids in predicting the compound’s pharmacokinetic and pharmacodynamics profiles and optimizing dosing regimens. − Nutraceutical testing using OOC models can be linked to various stages of preclinical drug development for better predictive approach to assess screening, safety, efficacy, target validation, pharmacokinetics, and target interactions; therefore, by leveraging the advantages of OOC models, researchers can enhance the preclinical evaluation of nutraceuticals contributing to the efficient and informed development of nutraceutical interventions. − The integration of OOC platforms in nutraceutical testing can provide valuable insights and complement traditional preclinical in vitro models. Target validation and screening are essential during the early stages of preclinical drug development. − Evaluating the efficacy of nutraceuticals is a crucial step in preclinical drug development.…”

Section: Types Of Ooc Models For Nutraceutical Testingmentioning

confidence: 99%

“…Once regulatory approval is obtained, the OOC technology can be introduced to the market for nutraceutical testing. Market entry strategies must involve establishing partnerships with nutraceutical companies, research institutions, or contract research organizations (CROs) to promote the adoption and usage of the OOC platform. − …”

Section: Types Of Ooc Models For Nutraceutical Testingmentioning

confidence: 99%

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Organ-on-Chip: Advancing Nutraceutical Testing for Improved Health Outcomes

Farooqi,

Kang,

Choi

2023

ACS Omega

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The recent global wave of organic food consumption and the vitality of nutraceuticals for human health benefits has driven the need for applying scientific methods for phytochemical testing. Advanced in vitro models with greater physiological relevance than conventional in vitro models are required to evaluate the potential benefits and toxicity of nutraceuticals. Organ-onchip (OOC) models have emerged as a promising alternative to traditional in vitro models and animal testing due to their ability to mimic organ pathophysiology. Numerous studies have demonstrated the effectiveness of OOC models in identifying pharmaceutically relevant compounds and accurately assessing compound-induced toxicity. This review examines the utility of traditional in vitro nutraceutical testing models and discusses the potential of OOC technology as a preclinical testing tool to examine the biomedical potential of nutraceuticals by reducing the need for animal testing. Exploring the capabilities of OOC models in carrying out plant-based bioactive compounds can significantly contribute to the authentication of nutraceuticals and drug discovery and validate phytochemicals medicinal characteristics. Overall, OOC models can facilitate a more systematic and efficient assessment of nutraceutical compounds while overcoming the limitations of current traditional in vitro models.

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