Reply to Mabalirajan et al.: 15LO1 pathway activation—Are receptors important?

Zhao, Jiang; Wenzel, Sally E.

doi:10.1073/pnas.1119194109

Cited by 9 publications

(2 citation statements)

References 4 publications

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“…Indeed, one might hypothesize that rescuing such starvation-like phenotype would reveal differences between both experimental conditions. Notably, socialization-induced behavioral changes are sexually dimorphic, since grouped and single-reared females behave similarly 44 . Indeed, male-specific P1 interneurons act as an internal state regulatory hub for sleep, aggression, sleep and spontaneous 45 .…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, male-specific P1 interneurons act as an internal state regulatory hub for sleep, aggression, sleep and spontaneous 45 . Together with Diuretic hormone 44-(DH44) and Tachykinin-(TK) expressing interneurons, P1 neurons form a malespecific neural circuit that regulates spontaneous locomotion in response to social interaction, thus suggesting a possible common mechanism for socially-induced behavioral changes 44 .…”

Section: Discussionmentioning

confidence: 99%

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Socialization causes long-lasting behavioral changes

Gil-Martí,

Isidro-Mézcua,

Poza-Rodriguez

et al. 2024

Preprint

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In modern human societies, social isolation acts as a negative factor for health and life quality. On the other hand, social interaction also has profound effects on animal and human behaviors, reducing aggressiveness, feeding and loss of sleep. Here, we observe that in the fly Drosophila melanogaster these behavioral changes long-last even after social interaction has ceased, suggesting that the socialization experience triggers behavioral plasticity. We find that impairing long-term memory mechanisms either genetically or by anesthesia abolishes the expected behavioral changes in response to social interaction. Furthermore, we show that socialization increases CREB-dependent neuronal activity and synaptic plasticity in the mushroom body, the main insect memory center analogous to mammalian hippocampus. We propose that social interaction triggers socialization awareness, understood as long-lasting changes in behavior caused by experience with mechanistic similarities to long-term memory formation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Socialization causes long-lasting behavioral changes

Gil-Martí,

Isidro-Mézcua,

Poza-Rodriguez

et al. 2024

Preprint

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Grading facial expression is a sensitive means to detect grimace differences in orofacial pain in a rat model

Sperry

Welch

et al. 2018

Sci Rep

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Although pre-clinical models of pain are useful for defining relationships between biological mechanisms and pain, common methods testing peripheral sensitivity do not translate to the human pain experience. Facial grimace scales evaluate affective pain levels in rodent models by capturing and scoring spontaneous facial expression. But, the Rat Grimace Scale (RGS) has not assessed the common disorder of temporomandibular joint (TMJ) pain. A rat model of TMJ pain induced by jaw loading (1 hr/day for 7 days) was used to investigate the time course of RGS scores and compare them between different loading magnitudes with distinct peripheral sensitivity profiles (0N–no sensitivity, 2N–acute sensitivity, 3.5N–persistent sensitivity). In the 3.5N group, RGS is elevated over baseline during the loading period and one day after loading and is correlated with peripheral sensitivity (ρ = −0.48, p = 0.002). However, RGS is not elevated later when that group exhibits peripheral sensitivity and moderate TMJ condylar cartilage degeneration. Acutely, RGS is elevated in the 3.5N loading group over the other loading groups (p < 0.001). These findings suggest that RGS is an effective tool for detecting spontaneous TMJ pain and that spontaneous pain is detectable in rats that develop persistent TMJ sensitivity, but not in rats with acute resolving sensitivity.

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A non-classical route of efficient plant uptake verified with fluorescent nanoparticles and root adhesion forces investigated using AFM

Sharma

Muddassir

Muthusamy

et al. 2020

Sci Rep

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Classical plant uptake is limited to hydrophilic or water-dispersible material. Therefore, in order to test the uptake behaviour of hydrophobic particles, here, we tested the fate of hydrophobic particles (oleylamine coated Cu2-xSe NPs (CS@OA)) in comparison to hydrophilic particles (chitosan-coated Cu2-xSe NPs (CS@CH)) by treatment on the plant roots. Surprisingly, hydrophobic CS@OA NPs have been found to be ~ 1.3 times more efficient than hydrophilic CS@CH NPs in tomato plant root penetration. An atomic force microscopy (AFM) adhesion force experiment confirms that hydrophobic NPs experience non-spontaneous yet energetically favorable root trapping and penetration. Further, a relative difference in the hydrophobic vs. hydrophilic NPs movement from roots to shoots has been observed and found related to the change in protein corona as identified by two dimensional-polyacrylamide gel electrophoresis (2D-PAGE) analysis. Finally, the toxicity assays at the give concentration showed that Cu2-xSe NPs lead to non-significant toxicity as compared to control. This technology may find an advantage in fertilizer application.

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Reply to Mabalirajan et al.: 15LO1 pathway activation—Are receptors important?

Abstract: We appreciate the opportunity to respond to the comments of Mabalirajan et al.(1) on our recent article (2). Their three critical points are addressed below.

Cited by 9 publications

References 4 publications

Socialization causes long-lasting behavioral changes

Socialization causes long-lasting behavioral changes

Grading facial expression is a sensitive means to detect grimace differences in orofacial pain in a rat model

A non-classical route of efficient plant uptake verified with fluorescent nanoparticles and root adhesion forces investigated using AFM

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