Abstract:In their Matters Arising article, Uffelmann et al. 1 present simulation experiments suggesting that the approach used in 2 , where genome-wide association studies are based on polygenic risk score-derived phenotypes, may lead to inflated positive rates. We acknowledge the importance of confirming the increased number of false positive results by performing simulation experiments but have reservations about how these impact our interpretation of data and subsequent conclusions derived from the results in the or… Show more
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