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VanWormer, Jeffrey J.; Bateman, Allen C.; Irving, Stephanie A.; Kieke, Burney A.; Shay, David K.; Belongia, Edward A.

doi:10.1093/infdis/jit810

Journal of Infectious Diseases

2013

DOI: 10.1093/infdis/jit810

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Jeffrey J. VanWormer

Allen C. Bateman

Stephanie A. Irving

et al.

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2016

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“…In a post hoc analysis of a clinical trial, the immune response to influenza vaccine was lower among persons receiving statin therapy, compared with those not receiving statin therapy [ 1 ]. Another study using administrative records found that statin therapy was associated with lower influenza VE against nonspecific respiratory illness, but laboratory-confirmed influenza was not assessed [ 2 ], which may conflate the influence of statins [ 3 ].…”

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Effect of Statin Use on Influenza Vaccine Effectiveness

et al. 2016

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Background. Recent studies suggest that statin use may reduce influenza vaccine effectiveness (VE), but laboratory-confirmed influenza was not assessed.Methods. Patients ≥45 years old presenting with acute respiratory illness were prospectively enrolled during the 2004–2005 through 2014–2015 influenza seasons. Vaccination and statin use were extracted from electronic records. Respiratory samples were tested for influenza virus.Results. The analysis included 3285 adults: 1217 statin nonusers (37%), 903 unvaccinated statin nonusers (27%), 847 vaccinated statin users (26%), and 318 unvaccinated statin users (10%). Statin use modified VE and the risk of influenza A(H3N2) virus infection (P = .002) but not 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) or influenza B virus infection (P = .2 and .4, respectively). VE against influenza A(H3N2) was 45% (95% confidence interval [CI], 27%–59%) among statin nonusers and −21% (95% CI, −84% to 20%) among statin users. Vaccinated statin users had significant protection against influenza A(H1N1)pdm09 (VE, 68%; 95% CI, 19%–87%) and influenza B (VE, 48%; 95% CI, 1%–73%). Statin use did not significantly modify VE when stratified by prior season vaccination. In validation analyses, the use of other cardiovascular medications did not modify influenza VE.Conclusions. Statin use was associated with reduced VE against influenza A(H3N2) but not influenza A(H1N1)pdm09 or influenza B. Further research is needed to assess biologic plausibility and confirm these results.

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confidence: 99%

Effect of Statin Use on Influenza Vaccine Effectiveness

et al. 2016

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Reply to Fedson

Cited by 1 publication

References 13 publications

Effect of Statin Use on Influenza Vaccine Effectiveness

Effect of Statin Use on Influenza Vaccine Effectiveness

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