Abstract:We appreciate the opportunity to reply to the letter by Dlouha et al, 1 who have attempted to replicate the association of the FTO variant rs17818902 with obesity that we have recently identified in a selfcontained population of Sorbs from Germany. 2 To test the SNP in a population closely related to the Sorbs, the authors genotyped this polymorphism in a Czech-Slavonic population. They failed to replicate the initial association and postulated that gene-gene and/or gene-environmental interactions might explai… Show more
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