Reply [to “Comment on ‘Starfish debris measurements from Cosmos 5’ by Oscar P. Manley and Jack W. Carpenter”]

Manley, O. P.; Carpenter, J. W.

doi:10.1029/jz071i021p05203

Cited by 3 publications

(8 citation statements)

References 2 publications

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“…7 However, it is necessary for the implant to purchase enough bone, especially in the small epiphyseal fragment, in order to achieve stability of the construct. 7 15 Anchoring using an intramedullary pin, as described in this technique, helps with alignment. Indeed, when placed in a normograde fashion, in a distal-to-proximal direction, satisfactory reduction or even slight overreduction is necessary to obtain correct positioning of the implant within the medullary cavity.…”

Section: Discussionmentioning

confidence: 99%

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Use of a Modified Intramedullary Pinning Technique for Distal Femoral Physeal Salter–Harris Type I and II Fracture Management: A Retrospective Study of 31 Cats

Bondonny,

Jacqmin,

Ferrand

et al. 2023

Vet Comp Orthop Traumatol

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Objective To report a modified intramedullary pinning technique, and associated outcomes, for distal femoral physeal Salter–Harris type I and II fracture management in cats. Study Design Retrospective study including client-owned cats presented between November 2014 and February 2022 with distal femoral physeal fractures treated with an intramedullary pin and one antirotational pin inserted in the lateral femoral condyle. Collected data included signalment, fracture characteristics according to the Salter–Harris classification, surgical data (intramedullary and antirotational pin sizes), and outcome data (radiographic and functional outcomes and complications). Results Thirty-one cats were included in this study. Bone healing was radiographically confirmed 6 to 8 weeks postoperatively in all cases. The majority of cats (30/31) were classified as full functional outcomes at mid-term follow-up. The overall mid-term complication rate was 3% (1/31). Implant migration was not observed and implant removal was not needed in any case. Conclusion The modified intramedullary pinning technique for distal femoral Salter–Harris I and II fracture management in cats was associated with an full functional outcome.

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Section: Discussionmentioning

confidence: 99%

“…This technique was first described by Parker in 1984 in a case series of 11 dogs and cats. 15 16 Here, we report the mid- and long-term outcomes after using this technique to manage Salter–Harris type I and II fractures of the distal femur in cats.…”

Section: Introductionmentioning

confidence: 99%

Use of a Modified Intramedullary Pinning Technique for Distal Femoral Physeal Salter–Harris Type I and II Fracture Management: A Retrospective Study of 31 Cats

Bondonny,

Jacqmin,

Ferrand

et al. 2023

Vet Comp Orthop Traumatol

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“…Due to the liability imposed on those who deforest, rates of deforestation should slow in 147 Over time, the Deforestation Survey shows that this is expected to slow significantly; in the period from 2013 to 2020, 17,000 hectares are expected to be deforested with an ETS (approximately 2400 hectares per year, a decrease in deforestation). 148 In that same period, MAF predicts that 63,000 hectares of land will be deforested (approximately 9000 hectares per year, an increase in deforestation) if there is no ETS. 149 The rate of conversion of land from forest to dairy has also slowed since the introduction of the ETS.…”

Section: Deforestationmentioning

confidence: 99%

“…148 In that same period, MAF predicts that 63,000 hectares of land will be deforested (approximately 9000 hectares per year, an increase in deforestation) if there is no ETS. 149 The rate of conversion of land from forest to dairy has also slowed since the introduction of the ETS. 150 It is also important to note that it is possible that deforestation has continued as usual;…”

Section: Deforestationmentioning

confidence: 99%

Preliminary Evidence on Responses to the New Zealand Forestry Emissions Trading Scheme

Karpas¹,

Kerr

2011

SSRN Journal

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New Zealand is the first country to implement a Greenhouse Gas Emissions Trading Scheme (ETS) that includes a forestry component as part of its contribution to global climate mitigation and as a strategy for compliance with the international climate change agreement the Kyoto Protocol. The goal of this paper is to provide information on forestry's role in the New Zealand ETS such that a foreign policymaker will be able to understand the intricacies and issues of the New Zealand system and be able to apply this knowledge to the design of his or her own ETS. This paper also aims to provide useful documentation of the system as it stands in 2010 for the New Zealand Parliament to use in future reviews of the system. The paper first provides a brief outline of the role of forestry in New Zealand's ETS, including the reasons for its inclusion in the greater system and the rules by which forestry operates within the system. This paper then analyses these rules, indicating the reasons behind the inclusion of certain provisions where the reasoning may not be immediately clear. Finally, this paper provides both quantitative and qualitative data on how well the system is working so far, whether the system is operating as predicted, and why any discrepancies between predicted and actual outcomes arise.

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“…Finally, decreased pre-systemic metabolism results in higher a bioavailability of unmetabolized drug, which means a smaller dosage can achieve the same exposure. 20,21 Many studies have already reported several deuterium-labeled entities, [22][23][24][25][26][27][28] and some of these have entered clinical trials including CTP-354, 20 CTP-449, 29 SD-254, and 21 SD-809. 19 The Auspex drug, SD-809, significantly reduced the incidence of uncontrolled movements in patients with Huntington's disease compared with a placebo, according to results from a phase III study announced recently, and it is expected to seek US approval for SD-809 in the middle of this year.…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis and biological evaluation of deuterated nintedanib for improving pharmacokinetic properties

Zhan

Peng

et al. 2015

Labelled Comp Radiopharmac

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Nintedanib is a novel triple angiokinase inhibitor that inhibits three growth factors simultaneously. Deuterated derivatives of nintedanib at certain metabolically active sites were prepared and evaluated in vitro and in vivo. In particular, deuterated compound SKLB-C2202 had significantly improved pharmacokinetic properties compared with nintedanib. These efforts lay the foundation for further investigating the druggability of SKLB-C2202.

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Reply [to “Comment on ‘Starfish debris measurements from Cosmos 5’ by Oscar P. Manley and Jack W. Carpenter”]

Cited by 3 publications

References 2 publications

Use of a Modified Intramedullary Pinning Technique for Distal Femoral Physeal Salter–Harris Type I and II Fracture Management: A Retrospective Study of 31 Cats

Use of a Modified Intramedullary Pinning Technique for Distal Femoral Physeal Salter–Harris Type I and II Fracture Management: A Retrospective Study of 31 Cats

Preliminary Evidence on Responses to the New Zealand Forestry Emissions Trading Scheme

Design, synthesis and biological evaluation of deuterated nintedanib for improving pharmacokinetic properties

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