Reply to comment on 'D-dimer and high-sensitivity C-reactive protein levels to predict venous thromboembolism recurrence after discontinuation of anticoagulation for cancer-associated thrombosis'

Jara‐Palomares, Luis; Asensio-Cruz, María Isabel; Elías-Hernández, Teresa; Marín-Romero, Samira; Otero, Remedios

doi:10.1038/s41416-018-0362-9

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…[67][68][69] Additional associated biomarkers revealed through more specialized testing include elevated soluble P-selectin adhesion molecule, 70,71 elevated prothrombin fragment 1 þ 2, 67 and elevated extracellular vesicles exposing tissue factor activity. 69,72,73 In fact, a few of these parameters have also been implicated in recurrent VTE in cancer patients, such as elevated D-dimer, 74 circulating tissue factor, 75 and soluble P-selectin adhesion molecule. 76 However, several of these tests are not routinely performed, in part due to cost considerations as well as the time to result.…”

Section: Discussionmentioning

confidence: 99%

Applications of Viscoelastic Testing in Breast Cancer Patients: A Systematic Review Focusing on Hypercoagulability and Free Flap Thrombosis

Pamulapati,

Conroy,

Madireddy

et al. 2023

Semin Thromb Hemost

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Viscoelastic testing is a clinically available method to assess hypercoagulability. This systematic review aims to provide a comprehensive overview of the existing literature and the potential use of such testing in patients with breast cancer. A systematic literature search for studies investigating the application of viscoelastic testing for patients with breast cancer was conducted. Studies were included as long as they were original, peer-reviewed, and in the English language. Studies were excluded if they were review articles, did not include breast cancer patients, or if the full text was unavailable. This review identified 10 articles that met the inclusion criteria. Two of the studies utilized rotational thromboelastometry, and an additional four studies used thromboelastography, to assess hypercoagulability in patients with breast cancer. Three of the identified articles discussed the use of thromboelastometry in free flap breast reconstruction for patients with breast cancer. One study was a retrospective chart review looking at thromboelastography and microsurgical breast reconstruction. Current literature regarding the application of viscoelastic testing in breast cancer and free flap breast reconstruction is limited, with no randomized trials thus far. However, some studies suggest that there may be potential utility in viscoelastic testing to assess risk for thromboembolism in breast cancer patients, and future research in this area is warranted.

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Section: Discussionmentioning

confidence: 99%

Applications of Viscoelastic Testing in Breast Cancer Patients: A Systematic Review Focusing on Hypercoagulability and Free Flap Thrombosis

Pamulapati,

Conroy,

Madireddy

et al. 2023

Semin Thromb Hemost

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“…Still, the small sample size may have been the cause. D‐dimer and high‐sensitivity C‐reactive protein levels may guide in determining the optimal anticoagulant treatment duration in CAT 54 . All variables should be considered from a broad perspective when deciding to continue treatment in patients.…”

Section: Doacsmentioning

confidence: 99%

Cancer‐associated thrombosis and drug–drug interactions of antithrombotic and antineoplastic agents

Bölek

Ürün

2023

Cancer

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Venous thromboembolism (VTE) is often associated with malignant diseases and notably contributes to morbidity and mortality in patients with cancer. Cancer‐associated thrombosis (CAT) brings additional costs to health expenditures and has a negative impact on oncological outcomes. Either the recurrence rate of VTE or bleeding complications are also higher in patients with cancer. Prophylactic anticoagulation has been recommended in peri‐surgical periods, inpatient settings, and high‐risk ambulatory patients. Although various risk stratification scores are used, none are ideal for identifying patients who can benefit from anticoagulant prophylaxis. New risk scoring systems or biomarkers are needed to identify patients who are more likely to benefit from prophylaxis with low bleeding risk. The questions about the patients who will be given prophylaxis and those who develop thromboembolism, with which drug, and how long they will be treated are still not fully answered. Anticoagulation is the cornerstone of the treatment, but management of CAT remains complex. Low molecular weight heparins and direct oral anticoagulants are effective and safe options for the treatment of CAT. Recognizing adverse effects, drug–drug interactions, and accompanying conditions that cause dose adjustment is crucial. Prevention and treatment of VTE in patients with cancer require a multidisciplinary and patient‐based approach.Plain Language Summary Cancer‐associated thrombosis is a significant cause of mortality and morbidity in patients with cancer. Chemotherapy, surgery, and/or use of central venous access remarkably increase the risk of thrombosis. Prophylactic anticoagulation should be considered not only in inpatient follow‐up and during peri‐surgical period but also ambulatory patients with a high risk of thrombosis. Many parameters, such as drug–drug interactions, primary side of cancer, and comorbidities of patients should be considered when selecting anticoagulant drugs. More accurate risk stratification scores or biomarkers are still an unmet need.

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Reply to comment on 'D-dimer and high-sensitivity C-reactive protein levels to predict venous thromboembolism recurrence after discontinuation of anticoagulation for cancer-associated thrombosis'

Cited by 2 publications

References 7 publications

Applications of Viscoelastic Testing in Breast Cancer Patients: A Systematic Review Focusing on Hypercoagulability and Free Flap Thrombosis

Applications of Viscoelastic Testing in Breast Cancer Patients: A Systematic Review Focusing on Hypercoagulability and Free Flap Thrombosis

Cancer‐associated thrombosis and drug–drug interactions of antithrombotic and antineoplastic agents

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