Reply to “Comment on ‘Chirality-Induced Electron Spin Polarization and Enantiospecific Response in Solid-State Cross-Polarization Nuclear Magnetic Resonance’”

Santos, J. Ignacio; Rivilla, Iván; Cossío, Fernando P.; García-García, Francisco J.; Matxain, Jon M.; Grzeliczak, Marek; Mazinani, Shobeir K. S.; Ugalde, Jesús M.; Mújica, Vladimiro

doi:10.1021/acsnano.9b00946

Cited by 4 publications

(5 citation statements)

References 12 publications

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“…Our results are primarily important to extend our fundamental understanding of the CISS-based mechanism underlying the enantioselective CP-MAS-SS-NMR response of optically active matter, which has been a subject of considerable controversy in the NMR community . In a different direction, the implications of having a controllable way of generating an enantioselective NMR response are considerable for the biosensing technologies in general and pharmacological in particular.…”

Section: Introductionmentioning

confidence: 84%

Enantiospecific Response in Cross-Polarization Solid-State Nuclear Magnetic Resonance of Optically Active Metal Organic Frameworks

et al. 2020

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We report herein on a NMR-based enantiospecific response for a family of optically active metal−organic frameworks. Cross-polarization of the 1 H− 13 C couple was performed, and the intensities of the 13 C nuclei NMR signals were measured to be different for the two enantiomers. In a direct-pulse experiment, which prevents cross-polarization, the intensity difference of the 13 C NMR signals of the two nanostructured enantiomers vanished. This result is due to changes of the nuclear spin relaxation times due to the electron spin spatial asymmetry induced by chemical bond polarization involving a chiral center. These experiments put forward on firm ground that the chiral-induced spin selectivity effect, which induces chemical bond polarization in the J-coupling, is the mechanism responsible for the enantiospecific response. The implications of this finding for the theory of this molecular electron spin polarization effect and the development of quantum biosensing and quantum storage devices are discussed.

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Section: Introductionmentioning

confidence: 84%

Enantiospecific Response in Cross-Polarization Solid-State Nuclear Magnetic Resonance of Optically Active Metal Organic Frameworks

et al. 2020

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“…Using 2 H NMR to analyse deuterated chiral guests inside of CMOF has not yet been explored. The chiral‐induced spin selectivity effect has additionally been proposed to obtain an enantiospecific response for solid state 13 C NMR due to changes in the T 1 relaxation time [52,57–59] …”

Section: Spectroscopic Methods Of Detection For Chiral Chemical Sensorsmentioning

confidence: 99%

“…The chiral-induced spin selectivity effect has additionally been proposed to obtain an enantiospecific response for solid state 13 C NMR due to changes in the T 1 relaxation time. [52,[57][58][59] High throughput and routine use of SS NMR for probing enantiopurity however is challenging given the specialist and expensive instrumentation required, but nonetheless enables important structural information to be gained. The powdered as synthesised form of CMOFs need to be converted into a pellet-type system that enable chiral guest mixtures to be inserted, analysed, and subsequently removed to enable reusability of the system.…”

Section: Solid-state Nuclear Magnetic Resonancementioning

confidence: 99%

Chiral Metal‐Organic Frameworks with Spectroscopic Methods: Towards Chemical Sensor Devices

Hubber,

Hua

2024

Chemistry A European J

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Chiral Metal‐Organic Frameworks (CMOFs) are a rapidly growing field reflecting their potential as selective and sensitive chemical sensors for chiral analytes. The highly tuneable nature of CMOFs enables the size, shape, and non‐covalent interactions to be optimised towards specific analytes to engender strong intermolecular interactions and sensing responses. While CMOFs as chiral chemical sensor devices have been explored with electrochemical methods including differential pulse voltammetry (DPV), bipolar and chemiresistive sensing techniques, the CMOFs as chiral chemical sensors using spectroscopic methods has received significantly less attention. This review examines the synthesis of CMOFs for chemical sensors with spectroscopic methods such as photoluminescence, circular dichroism, and solid‐state nuclear magnetic resonance with a view towards their incorporation into chemical sensor devices. Future directions of the field are highlighted for the generation of functional devices.

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“…Readers interested in the background and discussion are directed to a prior publication by the same authors in ACS Nano, 1 with accompanying critical commentary by a third party 2 and reply by the authors. 3 It is also noted that the two MOF samples constructed from L-tartaric and D-tartaric acid linkers reported to be enantiomers were not actually enantiomers; thus, further experimentation is required to support the claims of the manuscript.…”

mentioning

confidence: 97%

“…The Editor in Chief has been apprised of divergent views on the results reported and discussed in this Article and their interpretation. Readers interested in the background and discussion are directed to a prior publication by the same authors in ACS Nano , with accompanying critical commentary by a third party and reply by the authors …”

mentioning

confidence: 99%

Addition to “Enantiospecific Response in Cross-Polarization Solid-State Nuclear Magnetic Resonance of Optically Active Metal Organic Frameworks”

Carreira¹

2021

J. Am. Chem. Soc.

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Metrics & More Article RecommendationsThe Editor in Chief has been apprised of divergent views on the results reported and discussed in this Article and their interpretation. Readers interested in the background and discussion are directed to a prior publication by the same authors in ACS Nano, 1 with accompanying critical commentary by a third party 2 and reply by the authors. 3 It is also noted that the two MOF samples constructed from L-tartaric and D-tartaric acid linkers reported to be enantiomers were not actually enantiomers; thus, further experimentation is required to support the claims of the manuscript.

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Reply to “Comment on ‘Chirality-Induced Electron Spin Polarization and Enantiospecific Response in Solid-State Cross-Polarization Nuclear Magnetic Resonance’”

Cited by 4 publications

References 12 publications

Enantiospecific Response in Cross-Polarization Solid-State Nuclear Magnetic Resonance of Optically Active Metal Organic Frameworks

Enantiospecific Response in Cross-Polarization Solid-State Nuclear Magnetic Resonance of Optically Active Metal Organic Frameworks

Chiral Metal‐Organic Frameworks with Spectroscopic Methods: Towards Chemical Sensor Devices

Addition to “Enantiospecific Response in Cross-Polarization Solid-State Nuclear Magnetic Resonance of Optically Active Metal Organic Frameworks”

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