Reply to “comment on ‘binding free energies of inhibitors to iron porphyrin complex as a model for cytochrome P450’”

Lee, Joo Yun; Kang, Nam Sook; Kang, Young Kee

doi:10.1002/bip.22040

Cited by 1 publication

(2 citation statements)

References 7 publications

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“…Importantly, iron porphine maintained its sensitivity for most of the measured gases, owing to its two strong axial coordination sites. These different behaviors between zinc and iron porphines can be supported by two separate studies by Schalk [ 35 ] and Kang [ 42 ]. They calculated the binding energies of water molecules to zinc and iron porphyrinic systems and showed that zinc porphine has a higher affinity to water molecules than that of iron porphine.…”

Section: Resultsmentioning

confidence: 70%

“…Among the three metalloporphines, iron porphine showed the highest intensity to all the measured gases, especially to propionic acid ( Figure 4 ). This was expected as the central iron atom can bind to two extra axial ligands to form octahedral hexadentate coordination [ 42 ]. This was in agreement with the literature reporting higher ligand binding of iron porphyrin than that of zinc and nickel derivatives [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

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Effects of Center Metals in Porphines on Nanomechanical Gas Sensing

Ngo

Minami

Imamura

et al. 2018

Sensors

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Porphyrin is one of the most promising materials for realizing a practical artificial olfactory sensor system. In this study, we focus on non-substituted porphyrins—porphines—as receptor materials of nanomechanical membrane-type surface stress sensors (MSS) to investigate the effect of center metals on gas sensing. By omitting the substituents on the tetrapyrrole macrocycle of porphyrin, the peripheral interference by substituents can be avoided. Zinc, nickel, and iron were chosen for the center metals as these metalloporphines show different properties compared to free-base porphine. The present study revealed that iron insertion enhanced sensitivity to various gases, while zinc and nickel insertion led to equivalent or less sensitivity than free-base porphine. Based on the experimental results, we discuss the role of center metals for gas uptake from the view point of molecular interaction. We also report the high robustness of the iron porphine to humidity, showing the high feasibility of porphine-based nanomechanical sensor devices for practical applications in ambient conditions.

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Section: Resultsmentioning

confidence: 70%

Section: Resultsmentioning

confidence: 99%