Reply to Agrawal and Kumar

Kansagra, Kevinkumar; Parmar, Deven; Mendiratta, Sanjeev Kumar; Patel, Jatin; Joshi, Shuchi; Sharma, Nitin; Parihar, Anurag; Bhoge, Swapnil; Patel, Harilal; Kalita, Pankaj; Munshi, Renuka; Kurmi, Prakash; Shah, Ruchir; Gupta, Abhishek; Bhalla, Hira Lal; Bekkalele, Harish; Verma, Rajendra Kumar; Agarwal, Dinesh; Sharma, Shrikant; Gawande, Avinash; Chhaya, Gaurav

doi:10.1093/cid/ciaa1507

Cited by 1 publication

(1 citation statement)

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“…Despite the longstanding awareness of this disease, there is no effective cure. Previous studies have identified a variety of compounds that show inhibitory effects on RABV including ribavirin, IFN-α, ketamine, amantadine 20 and new antiviral agents in development like immunotherapeutics in the form of monoclonal antibodies targeting specific RABV proteins [21][22][23] but their therapeutic benefits are limited and require further research. 24 Dermaseptins secreted by amphibian skin have been shown to inhibit RABV in vitro and enhance survival in infected mice.…”

Section: Discussionmentioning

confidence: 99%

The study of anti‐rabies virus effect of Shougong powder

Zhang,

Fan,

Wang

et al. 2024

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Rabies is a lethal infectious disease caused by rabies virus (RABV). The mortality rate is very high after the appearance of clinical symptoms, with a survival rate of almost 0%. There is presently no cure for rabies. In the present study, we investigated whether the extract of Shougong powder—a calcium powder prepared from gecko that has demonstrated immunomodulatory properties in mice—is an effective treatment for rabies. The antiviral effects of the extract were evaluated both in vitro and in vivo with the cytotoxicity and antiviral assays and by immunofluorescence analysis, quantitative real‐time (qRT)‐PCR, and western blotting. The results showed that Shougong powder and its extract increased survival rate in RABV‐infected mice is up to 60% and 50%, respectively, even in 20 times of LD50, whereas the control groups treated with isoprinosine (IPS) or saline are only 20% and 0% survival (p = .011). qRT‐PCR and western blotting analyses showed that the extract strongly inhibited viral mRNA expression and protein synthesis in vitro: expression of the N, P, M, G, and L genes of RABV was decreased by 28.8%–45.0% in the IPS group (p < .05) and by 50.1%–59.0% in the extract group (p < .05) relative to the control group. These results demonstrate that Shougong powder has certain antiviral effects against RABV and can potentially be used for the treatment for rabies.

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