Reply. Impact of assay design on test performance: lessons learned from 25-hydroxyvitamin D. Authors’ response to the Letter to the Editor by Donnelly et al.
Abstract:We would like thank Donnelly and his colleagues from Siemens for their comments [1] on our recent study that evaluated the impact of assay design on 25-hydroxyvitamin D (25-OHD) immunoassay performance [2]. In their Letter to the Editor they question some statements and conclusions in the original paper that we would like to comment on. The first point raised is the sequence in their assay in which vitamin D is liberated from vitamin D binding protein (DBP). Donnelly and colleagues claim that the Siemens assay… Show more
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