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3D QSAR studies of 1,3,4-benzotriazepine derivatives as CCK2 receptor antagonists

“…Hence, efforts have been made to develop agents that inhibit gastrin activity especially on gastric secretion, by acting as CCK 2 R antagonists [8]. These compounds have been found to be beneficial in the treatment of gastric acid-related disorders, such as gastro esophageal reflux disease (GERD), proton pump inhibitor (PPI)-evoked rebound acid hypersecretion [9], and in certain types of cancer [10][11][12].…”