Abstract:We read with interest the article by Nakamura et al. 1 reporting clinical and prognostic significance of autoantibodies to nuclear pore gp210 antigen and centromere in primary biliary cirrhosis (PBC). By studying 276 Japanese patients, the authors found that anti-gp210 antibody positivity was a risk factor for progression to end-stage hepatic failure and related to disease severity whereas anti-centromere antibody positivity predicted progression to complications of portal hypertension, such as esophageal var… Show more
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