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Laine, Loren; Dubois, Raymond.

doi:10.1111/j.1365-2036.2004.02015.x

Cited by 2 publications

(3 citation statements)

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“…Organotin compounds are mostly known for their biocidal effects and have been widely used as wood preservatives, acaricides, disinfectants, bactericides, fungicides, molluskicides, PVC stabilizers, and marine antifouling products [5]. Since, serendipitous discovery of the antiproliferative activity of cisplatin; which was the first metal-containing anticancer drug, much effort have been shifted to the design of new metalbased drugs for oncology therapies [6]. Tin complexes are proposed to have therapeutic potential as alternatives to cisplatin and similar anticancer agents [5] since platinum and tin atoms possess common chemical properties [7].…”

Section: Introductionmentioning

confidence: 99%

Spectral Characterization and X-Ray Crystallographic Studies of Some Triphenyltin(IV) Dithiocarbamates Compounds

et al. 2018

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Three novel triphenyltin(IV) compounds with N-(2-methoxyethyl)-N-methyldithiocarbamate (1), N-benzyl-N-phenethyldithiocarbamate (2) and N-methyl-N-hexyldithiocarbamate (3) ligands have been successfully synthesized via in situ insertion method. The newly synthesized compounds gave fairly sharp melting points indicating their purity and were successfully isolated as crystalline solids. All the compounds have been characterized by CHNS elemental analysis, FT-IR, 1 H, 13 C and 119 Sn NMR spectroscopies. A single C-S vibration band around 1000 cm -1 was observed in all compounds, suggesting bidentate bonding of dithiocarbamate ligand to tin metal through both sulfur donor atoms. The crystal structures of all the compounds were determined by X-ray crystallography. All the compounds were crystallized in triclinic system having PI  space group. The single crystal X-ray diffraction data illustrated all three dithiocarbamato ligands are bidentate but in asymmetric fashion due to ∆(Sn-S) bond length and the geometry at the tin center is described as distorted trigonal-bipyramidal.

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Section: Introductionmentioning

confidence: 99%

Spectral Characterization and X-Ray Crystallographic Studies of Some Triphenyltin(IV) Dithiocarbamates Compounds

et al. 2018

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“…In recent years, an increasing number of researchers have been occupied with the synthesis and investigation of novel metal-based complexes with anticancer properties, and the main driving force of this research work originates from the possibility of finding new compounds active towards selected cancer cells with reduced side effects and able to overcome the drawbacks associated with classical anticancer drugs such as cisplatin. [1,2] In this field, copper complexes have received encouraging perspectives. [3,4] As an essential trace element in all living systems, copper plays an important role in mammalian cellular metabolism and offers diverse chemistries for the design of anticancer agents not accessible to organic compounds, including a wide range of coordination numbers, various oxidation states and ligand substitution kinetics.…”

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confidence: 99%

“…[27] Therefore, studies of interactions of metal complexes with DNA/proteins have far-reaching significance for the design and synthesis of new effective drugs. [28,29] Based on the above considerations and as a continuation of our interest in this area, [30,31] (2) (pzta: 6-(pyrazin-2-yl)-1,3,5-triazine-2,4-diamino (Scheme 1); L-Val: L-valinate; L-Thr: L-threoninate), were synthesized and characterized. The properties of the DNA binding of the complexes were studied using electronic absorption, competitive fluorescence titration, circular dichroism (CD) and viscosity measurements, and the HSA binding behaviors of the complexes were also studied using fluorescence quenching titration and synchronous fluorescence spectroscopy.…”

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confidence: 99%

Synthesis, crystal structures and DNA/human serum albumin binding of ternary Cu(II) complexes containing amino acids and 6‐(pyrazin‐2‐yl)‐1,3,5‐triazine‐2,4‐diamino

Zhang

Liu

et al. 2017

Applied Organom Chemis

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Two water‐soluble 6‐(pyrazin‐2‐yl)‐1,3,5‐triazine‐2,4‐diamino (pzta)‐based Cu(II) complexes, namely [Cu(l‐Val)(pzta)(H2O)]ClO4 (1) and [Cu(l‐Thr)(pzta)(H2O)]ClO4 (2) (l‐Val: l‐valinate; l‐Thr: l‐threoninate), were synthesized and characterized using elemental analyses, molar conductance measurements, spectroscopic methods and single‐crystal X‐ray diffraction. The results indicated that the molecular structures of the complexes are five‐coordinated and show a distorted square‐pyramidal geometry, in which the central copper ions are coordinated to N,N atoms of pzta and N,O atoms of amino acids. The interactions of the complexes with DNA were investigated using electronic absorption, competitive fluorescence titration, circular dichroism and viscosity measurements. These studies confirmed that the complexes bind to DNA through a groove binding mode with certain affinities (Kb = 4.71 × 103 and 1.98 × 103 M−1 for 1 and 2, respectively). The human serum albumin (HSA) binding properties of the complexes were also evaluated using fluorescence and synchronous fluorescence spectroscopies, indicating that the complexes could quench the intrinsic fluorescence of HSA in a static quenching process. The relevant thermodynamic parameters revealed the involvement of van der Waals forces and hydrogen bonds in the formation of complex–HSA systems. Finally, molecular docking technology was also used to further verify the interactions of the complexes with DNA/HSA.

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Cited by 2 publications

References 8 publications

Spectral Characterization and X-Ray Crystallographic Studies of Some Triphenyltin(IV) Dithiocarbamates Compounds

Spectral Characterization and X-Ray Crystallographic Studies of Some Triphenyltin(IV) Dithiocarbamates Compounds

Synthesis, crystal structures and DNA/human serum albumin binding of ternary Cu(II) complexes containing amino acids and 6‐(pyrazin‐2‐yl)‐1,3,5‐triazine‐2,4‐diamino

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