Reply by Authors to J.A. Miller

Recovery of trifluoroacetic acid from dilute aqueous solutions by reactive distillation

“…It is also used as an intermediate in the preparation of active molecules used in pharmaceutical applications. The preparation of trifluoroacetates by esterification of TFA with various alcohols and other routes of synthesis are described in various patents [6][7][8][9][10][11][12].…”

“…One way of circumventing this bottleneck problem is to convert the acid to useful products like isopropyl trifluoroacetate (IPTFA) and separate IPTFA from the mixture by distillation. Esters of trifluoroacetic acid are fine chemical intermediates, which are used in the manufacture of pharmaceuticals, agricultural chemicals, liquid crystals, dyes and industrial chemicals [6]. IPTFA is used as a water scavenger and as a solvent in the manufacture of various chemicals [7][8][9][10].…”