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Been, Jasper V; Zimmermann, Luc J. I.; Jonkers, Femke; Rours, Ingrid G.I.J.G.; Kornelisse, René F.; Krijger, Ronald R. de

doi:10.1016/j.jpeds.2010.06.015

Cited by 1 publication

(2 citation statements)

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“…This finding was similar to other studies. 7,16 Secondly, infants born by cesarean delivery are also more likely to develop NARDS. We analyzed that this may be associated with increased fluid in the lungs and insufficient lymphatic drainage of the lungs without fluid in the lungs can be compressed through the vaginal delivery as the pathophysiological factor for transient tachypnea of the newborn (TTN).…”

Section: Discussionmentioning

confidence: 99%

“…Multiple risk factors, such as perinatal asphyxia, meconium aspiration syndrome, biliary pneumonia, and neonatal respiratory disorders following severe chorioamnionitis and sepsis are involved in the development of NARDS. [4][5][6][7] Neonatal sepsis may rapidly progress to multisystem organ failure, still present high mortality of 4.5‰~9.7‰, 8 and is also known as a frequent and important cause for NARDS. Effective antibiotic therapy is the most important strategy in the treatment of sepsis.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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Risk Factors of Neonatal Acute Respiratory Distress Syndrome Based on the Montreux Definition in Neonates with Sepsis: A Retrospective Case–Control Study

Chen

Wang

et al. 2022

Am J Perinatol

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Objective To analyze the risk factors for neonatal acute respiratory distress syndrome (NARDS) development based on the Montreux definition among near- and full-term neonates with sepsis and received meropenem. Study Design This was a single-center, case-control, retrospective trial from January 2019 to June 2020. Newborns of gestational ages (GAs) ≥ 35 weeks, diagnosed with sepsis and received meropenem were included. Patients who developed NARDS subsequently were defined as the study group (NARDS group), while the others without NARDS were enrolled in the control group (Non-NARDS group). Results Out of 213 eligible neonates, NARDS occurred in 52 (24.4%) cases. In univariate analysis, infants with NARDS had a lower GA and birth weight, but a higher rate of premature birth (p <0.05). The median onset times of sepsis were earlier among neonates with NARDS compared to those without NARDS (1 (1,1) versus 6 (1,15) days, p < 0.001)). Neonates with NARDS were more likely to suffer from early-onset sepsis (EOS), persistent pulmonary hypertension of newborns, pulmonary hemorrhage, septic shock, and patent ductus arteriosus (p <0.05). During labor, women whose neonates experienced NARDS were more likely to cesarean delivery (67.3% versus 46.6%, p = 0.009) and to receive at least one dose of corticosteroids (21.2% versus 5.0%, p = 0.001). In multivariable analyses, factors remaining independently associated with NARDS were premature birth, cesarean delivery, EOS, and septic shock. Compared with conventional inflammatory markers for NARDS, PCT was correlating with septic neonates who developed NARDS (p =0.012) but had a low diagnostic value (AUC =0.609). CRP, WBC, and PLT did not correlate with morbidity of NARDS (AUC <0.05 and p >0.05). Conclusions Premature birth, cesarean delivery, EOS, and septic shock were independently associated with NARDS among near- and full-term septic neonates. PCT showed limited predictive value for NARDS.

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Section: Discussionmentioning

confidence: 99%