Reply

Abstract

stripping automated endothelial keratoplasty: a multicenter randomized controlled clinical trial. Ophthalmology. 2020;127: 1152e1159. 3. Chamberlain W, Lin CC, Austin A, et al. Descemet endothelial thickness comparison trial: a randomized trial comparing ultrathin Descemet stripping automated endothelial keratoplasty with Descemet membrane endothelial keratoplasty. Ophthalmology. 2019;126:19e26. 4. Wacker K, Baratz KH, Maguire LJ, et al. Descemet stripping endothelial keratoplasty for fuchs' endothelial corneal dystrophy: five-year results of a prospective study. Ophthalmology. 2016;123:154e160. 5. Wacker K, Baratz KH, Bourne WM, et al. Patient-reported visual disability in Fuchs' endothelial corneal dystrophy measured by the visual function and corneal health status instrument. Ophthalmology. 2018;125:1854e1861. REPLY: In randomized clinical trials, inherent variability is due to several known and unknown sources of bias. Consequently, although the means of visual acuity from various studies on Descemet stripping automated endothelial keratoplasty (DSAEK) seem to converge to a similar value, it is important to note that wide variations in graft thickness were represented by a relatively limited sample size (n ¼ 25 in both clinical trials). An analysis using averages alone may not tell the whole story, especially with regards to the influence of graft thickness on overall asymmetry. With a wider possible range of pachymetry values along different points, thicker grafts tend to have greater posterior corneal asymmetry, which in turn affects visual outcomes. 1,2 Conversely, when the intended graft thickness is <100 mm, as in ultrathin DSAEK, there is a greater probability of obtaining a regular and symmetric graft, thus resulting in better vision. 3 Although highly functional vision can still be achieved in a large number of cases, raising the bar for DSAEK must also involve standardized graft preparation that yields consistent graft quality. 4

Partnership Relations In The Field Of Small Business: Regional Aspect

“…So, in 2011 was signed an agreement between the Department of Economic Development of the region and the Belgorod regional branch of the Russian public organization "Center of counteraction of corruption in government», and according to this agreement, under the terms of co-financing from the regional and federal budgets for the implementation of the program activities of the public organizations, there were given the subsidies in the amount of 350 thousand rubles. This step has already become the next one from the authorities to support non-profit organizations in the region (Busin, 2012). At the end of 2010 a regional competition was held, according to resolution of the government of Belgorod Region "On approval of the long-termed target program «Support of socially-oriented non-profit organizations in Belgorod Region» (Belgorod Government, 2011a) and the decree of the regional government «About the competition of socially oriented non-profit organizations for the right to receive subsidies in 2011» (Belgorod Government, 2011b).…”