“…Overlap diseases of RA and SSc have been reported previously, but in most of those patients, scleroderma was not limited and, in contrast to the 3 patients reported herein, antibodies to topoisomerase, but not to centromere antigens, were detected (5,(12)(13)(14)(15)(16)(17)(18)(19). Raynaud's phenomenon had developed between 14 years before and 16 years after the occurrence of arthritis.…”