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Risk of nonalcoholic steatohepatitis and fibrosis in patients with nonalcoholic fatty liver disease and low visceral adiposity

“…In an attempt to identify the variables predictive of fibrosis, several authors have investigated a variety of markers including demographic, anthropometric, biochemical, and clinical parameters, but no conclusive results have been reached [26], [27], [28], [29], [30] and [31]. Variables related to glucose control (impaired glucose metabolism/diabetes) were more frequently identified [8], [26], [27] and [28] as predictive of fibrosis, whereas the relation of increased BMI with fibrosis was uncertain.…”

The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease

“…A defect in insulin sensitivity is the key pathogenic feature Studies suggest that the severity of insulin resistance is correlated with the likelihood of progression from benign steatosis to NASH and the development of fibrosis. (5,6,8,9). Therefore therapies that improve insulin sensitivity are also of benefit in NAFLD.…”

Hepatic Steatosis Is Associated With Adverse Molecular Signatures in Subjects Without Diabetes

“…Plasma insulin levels were measured (Centaur XP by Siemens Healthcare Diagnostics) and the homeostatic model assessment of insulin resistance (HOMA-IR) index was calculated as insulin (µU/ml) × glucose (mmol/l)/22.5 [22]. We calculated the AST/ALT ratio, the NAFLD-score [23] and the FIB4-score [24] to include surrogates of liver fibrosis. Cystatin C-based estimated glomerular filtration rate (eGFR) was calculated using the CKD-EPI equation [25].…”