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Abstract

below daily energy need constituted of 64% carbohydrate, 22% fat, and 14% protein. In our own experience, high carbohydrate intake is one of the major causes of unsuccessful weight reduction in these patients. 2,3 In addition high carbohydrate intake may induce the transcription factor carbohydrate response element binding protein (ChREBP), which may contribute to insulin resistance in these patients and subsequent development of NASH. 3 The contribution of fructose-enriched soft drinks should also be emphasized. Fructose-enriched soft drinks may induce NASH by triggering inflammatory signals and inducing the so called second "hit" of fat injury. 3 In this report, there was no detail on use of this type of beverage.Several studies have shown that a low carbohydrate diet is much more effective in weight reduction than a low-fat diet, even at equal calories. [4][5][6] In conclusion, this study emphasizes the need for better strategies in dietary modification for weight loss. We believe the current evidence favors more restriction in carbohydrate rather than fat to achieve this goal.

Changing Trends in Liver Transplantation: Challenges and Solutions

“…Lifestyle modification leads to histological improvements in NASH, as recently demonstrated. 142 Patients with medically complicated obesity (BMI ≥ 40 or BMI > 35 kg/ m 2 with significant obesity-related comorbidities) can benefit from bariatric surgery, which can not only result in substantial weight loss but also comorbidity resolution. 143,144 As bariatric surgery may not be feasible before LT because of potential for hepatic decompensation, a recently proposed alternative is to perform it concurrently with LT. 145,146 The Mayo Clinic group demonstrated the feasibility of combining SG with LT and noted more persistent weight loss with fewer metabolic complications on follow-up in patients undergoing LT and SG compared with a cohort of LT patients enrolled in an aggressive weight loss protocol.…”

Effect of Obesogenic Medications on Weight‐Loss Outcomes in a Behavioral Weight‐Management Program

“…program. This level of weight loss is associated with clinically meaningful outcomes, such as improvements in blood pressure, glycemia, and triglycerides (22)(23)(24). Responders ("cases") were defined as patients who were able to lose 5% or more from their intake total weight by the end of the MOVE!…”