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Dossarps, Denis; Bron, Alain M.; Koehrer, Philippe; Aho-Glélé, Ludwig S.; Creuzot‐Garcher, Catherine

doi:10.1016/j.ajo.2015.07.002

Cited by 4 publications

(3 citation statements)

References 2 publications

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“…Acute-onset infectious endophthalmitis continues to be the most feared and significant complication of intravitreal injections, causing severe and potentially irreversible vision loss and is defined by an onset within 6 weeks after surgical intervention [6-8]. Each injection of anti-VEGF agents such as bevacizumab, ranibizumab, or aflibercept carries a small associated risk of endophthalmitis with a reported incidence of endophthalmitis after anti-VEGF injection between 0.01 and 0.32% [9-15].…”

Section: Introductionmentioning

confidence: 99%

“…To date, all multicenter studies investigating postinjection endophthalmitis have been nationwide or regional only, including medical centers from a few specific countries such as France, the UK, and the USA [6, 7, 10-12, 14]. In these publications, injection settings and postinjection recommendations were mostly similar within countries or local regions due to guidelines set by the national regulatory agencies.…”

Section: Introductionmentioning

confidence: 99%

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Causative Pathogens of Endophthalmitis after Intravitreal Anti-VEGF Injection: An International Multicenter Study

et al. 2019

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Purpose: The main objective of this study was to investigate the microbiological spectrum of endophthalmitis after anti-VEGF injections and to compare streptococcal with non-streptococcus-associated cases with regard to baseline characteristics and injection procedure. Methods: Retrospective, international multicenter study of patients with culture-positive endophthalmitis after intravitreal anti-VEGF injection at 17 different retina referral centers. Results: Eighty-three cases with 87 identified pathogens were included. Coagulase-negative staphylococci (59%) and viridans streptococci (15%) were the most frequent pathogens found. The use of postoperative antibiotics and performance of injections in an operating room setting significantly reduced the rate of streptococcus-induced endophthalmitis cases (p = 0.01 for both). Conclusion: We found a statistically significant lower rate of postinjectional local antibiotic therapy and operating room-based procedures among the streptococcus-induced cases compared to cases caused by other organisms.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Causative Pathogens of Endophthalmitis after Intravitreal Anti-VEGF Injection: An International Multicenter Study

et al. 2019

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“…The strengths of the current study are (1) that it is one of the few to satisfy the "two-species" rule for establishing potential clinical efficacy, (2) it distinguishes between two competing hypotheses for how adult enucleation of the fellow eye enables recovery from amblyopia, and (3) the experiments demonstrate durable recovery from the effect of long-term MD after the end of the critical period. An injection of TTX (or equivalent) into the eye is not without risks that need to be carefully considered before contemplating human application (see, e.g., (Dossarps et al, 2015)). However, histological analysis of the cat retina and optic nerve revealed no deleterious effect of 10 days of TTX treatment (DiCostanzo et al, 2020), and the electrophysiological analyses and behavioral observations in the current study indicate complete functional recovery of vision in the injected eye.…”

Section: Discussionmentioning

confidence: 99%

Correction of amblyopia in cats and mice after the critical period

Fong

Duffy

Leet

et al. 2021

Preprint

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Monocular deprivation early in development causes amblyopia, a severe visual impairment. Prognosis is poor if therapy is initiated after an early critical period. However, clinical observations have shown that recovery from amblyopia can occur later in life when the non-deprived (fellow) eye is removed. The traditional interpretation of this finding is that vision is improved by relieving interocular suppression in primary visual cortex. However, an alternative explanation is that elimination of activity in the fellow eye establishes conditions in visual cortex that enable the weak connections from the amblyopic eye to gain strength. Here we show in cats and mice that temporary inactivation of the fellow eye is sufficient to promote a full and enduring recovery from amblyopia at ages when conventional treatments fail. Thus, connections serving the amblyopic eye are capable of substantial plasticity beyond the critical period, and this potential is unleashed by reversibly silencing the fellow eye.

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Intravitreal Injections with Vascular Endothelial Growth Factor Inhibitors: A Practical Approach

et al. 2020

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Intravitreal injections with vascular endothelial growth factor inhibitors constitute the most prevalent ophthalmic procedure in developed countries. Historically, there has been steady growth in the number of treatments performed of this kind, and projection studies estimate further growth in such treatments in the future. We provide a practical approach to intravitreal injections and discuss important aspects relating to the setting, the patient, the procedure, and the information given to the patient.

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Cited by 4 publications

References 2 publications

Causative Pathogens of Endophthalmitis after Intravitreal Anti-VEGF Injection: An International Multicenter Study

Causative Pathogens of Endophthalmitis after Intravitreal Anti-VEGF Injection: An International Multicenter Study

Correction of amblyopia in cats and mice after the critical period

Intravitreal Injections with Vascular Endothelial Growth Factor Inhibitors: A Practical Approach

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