Replicative Capacity of Human Immunodeficiency Virus From Patients With Varying Severity of Hiv Infection

HIV-1 Pathogenesis: The Virus

“…An early observation important for understanding viral pathogenesis was that some viruses isolated from people late in infection were able to grow and cause syncytia in transformed T-cell lines (Asjo et al 1986), earning the name syncytium-inducing (SI). The remaining viruses were dubbed nonsyncytiuminducing (NSI).…”

Human retroviruses and AIDS 1997

“…The patient had AIDS at the time of viral isolation in 1985. The virus exhibited rapid/high phenotype [Asjo et al(1986)] and when gpl20 from this isolate was swapped into the HXB2 genome, the ability of the chimeras to grow in various cell lines correlated with the gpl20 [McKeating et al(1996)]. Although the amino acid sequences translated from these sequence entries are clearly subtype B, the DNA sequences do not cluster with any of the HTV-1 M-group subtypes.…”

“…A Gag gene is available with accession number U86545. 14) SE.KI4803: This sequence is from patient number 24 described in [Asjo et al(1986)] and [Fredriksson et al(1991)]. Several molecular clones from this patient have been extensively characterized in [Tan et al(1993)].…”

Analysis of human immunodeficiency virus type 1 (HIV-1) variants and levels of infection in dendritic and T cells from symptomatic HIV-1-infected patients.

“…Virus from asymptomatic individuals is usually slow growing and non-syncytium inducing (NSI) and displays a tropism for macrophages but does not replicate in T cell lines. In contrast, symptomatic patients often harbour fast-growing syncytium inducing (SI) virus with a tropism for T cell lines but not for primary macrophages (Asjo et al, 1986 ;Cheng-Mayer et al, 1988 ;Fenyo et al, 1988 ;Tersmette et al, 1989 ;Chesebro et al, 1992 ;Fouchier et al, 1992Fouchier et al, , 1995. Infection in chronically infected individuals is characterized by the presence of many virus variants or quasi species (Meyerhans et al, 1989), but virus in acutely infected individuals is relatively homogeneous and usually of the NSI type (Roos et al, 1992 ;Zhang et al, 1993 ;Zhu et al, 1993).…”