“…Larger chromosomes were also found to missegregate more frequently in human cells when attachment error correction was compromised by inhibiting Aurora B kinase, when microtubules were stabilized by low concentrations of taxol, or when chromosome congression was compromised by inhibition of the mitotic kinesin CENP-E [ 49 , 50 ]. Interestingly, generating DNA damage in human cells during the interphase, using ionizing radiation or by causing replication stress, specifically elevated structural rearrangements and micronuclear incorporation of larger chromosomes as well [ 33 , 51 , 52 ]. Lastly, loss of endogenous CENP-A in human cells increased the segregation error frequency of chromosomes 6, X, and Y [ 53 , 54 ].…”