Replication protein A promotes 5′→3′ end processing during homology-dependent DNA double-strand break repair

Yan, Hong; Toczylowski, Thomas; McCane, Jill E.; Chen, Chin-Yi; Liao, Shuren

doi:10.1083/jcb.201005110

Cited by 37 publications

(48 citation statements)

References 54 publications

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“…The initial short-range resection of DNA ends by MRX-Sae2 is followed by long-range resection by Exo1 and Dna2-STR (DNA2-BTR) (Gravel et al 2008;Mimitou and Symington 2008;Zhu et al 2008;Cejka et al 2010;Niu et al 2010;Nimonkar et al 2011;Yan et al 2011;Symington 2014). Interestingly, the proteins involved in short-and long-range resection have distinct focal appearances giving clues to their function and regulation.…”

Section: Choreography Of Focus Formationmentioning

confidence: 99%

Cell Biology of Mitotic Recombination

Lisby

Rothstein

2015

Cold Spring Harb Perspect Biol

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Homologous recombination provides high-fidelity DNA repair throughout all domains of life. Live cell fluorescence microscopy offers the opportunity to image individual recombination events in real time providing insight into the in vivo biochemistry of the involved proteins and DNA molecules as well as the cellular organization of the process of homologous recombination. Herein we review the cell biological aspects of mitotic homologous recombination with a focus on Saccharomyces cerevisiae and mammalian cells, but will also draw on findings from other experimental systems. Key topics of this review include the stoichiometry and dynamics of recombination complexes in vivo, the choreography of assembly and disassembly of recombination proteins at sites of DNA damage, the mobilization of damaged DNA during homology search, and the functional compartmentalization of the nucleus with respect to capacity of homologous recombination.

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Section: Choreography Of Focus Formationmentioning

confidence: 99%

Cell Biology of Mitotic Recombination

Lisby

Rothstein

2015

Cold Spring Harb Perspect Biol

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show abstract

“…Proteins involved in HR include Rad51, RPA, XRCC2, BRCA1, BRCA2, etc. [1][2][3]. By contrast, NHEJ is the most straightforward way to repair a DSB, as the broken ends are simply rejoined regardless of the genetic sequences at the break.…”

Section: Introductionmentioning

confidence: 99%

Efficient ligase 3-dependent microhomology-mediated end joining repair of DNA double-strand breaks in zebrafish embryos

Zhang

Wang

et al. 2015

Mutation Research/Fundamental and Molecular Mechanisms of Mutag

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“…This complex also contains the exonuclease WRN which is activated by its association with DNA single strand protein RPA. 46,47 Curiously, PRPF19 contains a U-box domain, associated to E3 ubiquitin ligase activity. Although PRPF19 autoubiquitination was reported, other ubiquitination targets are still to be determined.…”

Section: Discussionmentioning

confidence: 99%