Abstract:The replication properties of a thymidine kinase-negative (TK ؊ ) mutant of herpes simplex virus type 1 (HSV-1) were exploited to examine the relative contributions of replication at the body surface and within trigeminal ganglia (TG) on the establishment of latent infections. The replication of a TK ؊ mutant, 17/tBTK ؊ , was reduced by ϳ12-fold on the mouse cornea compared to the rescued isolate 17/tBRTK ؉ , and no replication of 17/tBTK ؊ in the TG of these mice was detected. About 1.8% of the TG neurons of … Show more
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