Replication of Hepatitis B Virus

Warner, Nadia; Locarnini, Stephen

doi:10.1016/b978-1-4377-0881-3.00006-1

Cited by 7 publications

(10 citation statements)

References 90 publications

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“…1) (Warner and Locarnini, 2012 although the exact steps are not well understood (Nassal, 2008). 140 cccDNA is a minichromosome that serves as the template for viral 141 transcription, generating mRNAs that are 3.5-, 2.4-, 2.1-, and 0.7-kb 142 in size (Warner and Locarnini, 2012). The genome consists of a circular, partially double-stranded DNA molecule 3.2 kb in length.…”

mentioning

confidence: 99%

“…131 HBV contains a small, partially double-stranded genome that 132 consists of a full-length negative strand and an incomplete positive 133 strand ( Fig. 1) (Warner and Locarnini, 2012 although the exact steps are not well understood (Nassal, 2008). 140 cccDNA is a minichromosome that serves as the template for viral 141 transcription, generating mRNAs that are 3.5-, 2.4-, 2.1-, and 0.7-kb 142 in size (Warner and Locarnini, 2012).…”

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Chronic hepatitis B: Virology, natural history, current management and a glimpse at future opportunities

et al. 2015

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confidence: 99%

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Chronic hepatitis B: Virology, natural history, current management and a glimpse at future opportunities

et al. 2015

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“…A precise and stable binary period was found for AM CVn (Harvey et al 1998;Skillman et al 1999), and the puzzling array of photometric periods in this and other stars became readily understood as superhumps (precessional sidebands of the orbital frequency, analogous to those in the Earth-Moon-Sun system). In recent years, the roster has grown to ∼40 confirmed and probable members (Levitan et al 2015;Warner 2015).…”

Section: Introductionmentioning

confidence: 99%

Orbital Period Increase in ES Ceti

Miguel

Patterson

Kemp

et al. 2017

ApJ

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We report a long-term study of the eclipse times in the 10minute helium binary ES Ceti. The binary period increases rapidly, with P P 6.2 10 6=´years. This is consistent with the assumption that gravitational radiation (GR) drives the mass transfer, and it appears to be the first dynamical evidence that GR is indeed the driver of evolution in this class of very old cataclysmic variables-the AM Canum Venaticorum stars.

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“…), nephrotoxicity, myopathy, thrombocytopenia and severe ALT flares and long costly treatment including resistance. [3][4][5] Table 4 shows effect of treatment on proportion of patients who have reported symptoms on Likert Scale as "1", "2" and "3" at baseline for each symptom, were considered "affected". Proportion of affected patients who have reported symptoms on Likert Scale as "0" after treatment, were considered "relieved".…”

Section: Discussionmentioning

confidence: 99%

“…Negativity about social life and health has also been observed in chronic patients. [3][4][5] Antiviral agents such as entecavir, tenofovir and peg-IFN against HBV are available which have been shown to suppress HBV replication. However, conventional treatment fail to eradicate the virus in most of those treated patients and doesn't provide much relief to the associated symptoms.…”

Section: Introductionmentioning

confidence: 99%

Unani Formulation Improved Quality of Life in Indian Patients of Chronic Hepatitis B

Ansari¹,

Siddiqui²,

Malhotra³

et al. 2019

JYP

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Background: Chronic Hepatitis B (CHB) is a serious global healthcare burden with more than 257 million people infected worldwide. Patients of CHB gradually develop derangement in their physical and mental health with the chronicity of the disease. Unani medicine provides a holistic herbal treatment worthiest in the scenario of treatment strategy for chronic viral diseases with deranged quality of life. This study was conducted to evaluate the effect of Unani drugs on deranged quality of life in patients of CHB. Methods: In a pilot clinical trial, 30 patients of chronic Hepatitis B were evaluated for the improvement in their Quality of Life (QoL) after subjected to treatment with decoction of Saussurea lappa and Artemisia absinthium. Enrolled study subjects received treatment for 90 days and were assessed for QoL with a booklet of the instruments [EQ5D (EuroQol 5D-3L), HQLQ™ (Hepatitis quality of life questionnaire) and physical symptoms] at baseline, 7 th , 45 th and 90 th day. Results: Significant improvement was observed on EQ5D, HQLQ TM and physical symptoms. Conclusion: Decoction of Sau-ssurea lappa and Artemisia absinthium improved quality of life in the patients of chronic Hepatitis B. Further studies should be conducted to evaluate their effectiveness in improving quality of life in Hepatitis B induced cirrhosis of liver and hepatocellular carcinoma patients.

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Replication of Hepatitis B Virus

Cited by 7 publications

References 90 publications

Chronic hepatitis B: Virology, natural history, current management and a glimpse at future opportunities

Chronic hepatitis B: Virology, natural history, current management and a glimpse at future opportunities

Orbital Period Increase in ES Ceti

Unani Formulation Improved Quality of Life in Indian Patients of Chronic Hepatitis B

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