Replication of a genome-wide association study of panic disorder in a Japanese population

Otowa, Takeshi; Tanii, Hisashi; Sugaya, Nagisa; Yoshida, Eiji; Inoue, Ken; Yasuda, Shin; Shimada, Takafumi; Kawamura, Yoshiya; Tochigi, Mamoru; Minato, Takanobu; Umekage, Tadashi; Miyagawa, Taku; Nishida, Nao; Tokunaga, Katsushi; Okazaki, Yuji; Kaiya, Hisanobu; Sasaki, Tsukasa

doi:10.1038/jhg.2009.127

Cited by 48 publications

(37 citation statements)

References 42 publications

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“…CALCIUM-ACTIVATED CHLORIDE CHANNELS association with panic disorder in a genome-wide association study in the Japanese population, but its significance could not be replicated in later studies (Otowa et al, 2009(Otowa et al, , 2010. TMEM16E, also known as GDD1, is linked to gnathodiaphyseal dysplasia, a rare skeletal syndrome characterized by bone fragility, sclerosis of tubular bones, and cemento-osseous lesions of the jawbone.…”

Section: Transmembrane Protein 16a Family Members and Disease Corrmentioning

confidence: 99%

International Union of Basic and Clinical Pharmacology. LXXXV: Calcium-Activated Chloride Channels

Huang¹,

Wong²,

Jan³

2011

Pharmacol Rev

157

137

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Section: Transmembrane Protein 16a Family Members and Disease Corrmentioning

confidence: 99%

International Union of Basic and Clinical Pharmacology. LXXXV: Calcium-Activated Chloride Channels

Huang¹,

Wong²,

Jan³

2011

Pharmacol Rev

157

137

View full text Add to dashboard Cite

“…[27][28][29] Thus, a genome-wide association approach is increasingly being used to delineate such loci. 30,31 Additional, genome-wide association studies in larger population samples, as well as gene-environment interaction studies, are needed to confirm preliminary results.…”

Section: Pathogenesis Of Panic Disordermentioning

confidence: 98%

The assessment and treatment of panic disorder in general practice

Koen

Stein

2012

South African Family Practice

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Panic disorder (PD) is an anxiety disorder that affects many South Africans. If undiagnosed or mismanaged, this condition may impact profoundly on an individual's functioning and quality of life. At the primary level, the assessment of panic attacks requires consideration of a number of differential diagnoses. General practitioners also play an invaluable role in the acute and long-term care and appropriate referral of individuals with PD. This article provides an overview of PD in general practice and includes a guideline for case identification and therapeutic options.

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“…11 The diagnosis was confirmed according to the Diagnostic and Statistical Manual, 4th edition criteria, 1 using the Mini-International Neuropsychiatric Interview 12 and clinical records. Details of the recruitment of cases 13 and controls [13][14][15][16] are described elsewhere.…”

Section: Sample Recruitmentmentioning

confidence: 99%

A genome-wide CNV association study on panic disorder in a Japanese population

Kawamura¹,

Otowa

Koike

et al. 2011

J Hum Genet

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Family and twin studies have indicated that genetic factors have an important role in panic disorder (PD), whereas its pathogenesis has remained elusive. We conducted a genome-wide copy number variation (CNV) association study to elucidate the involvement of structural variants in the etiology of PD. The participants were 2055 genetically unrelated Japanese people (535 PD cases and 1520 controls). CNVs were detected using Genome-Wide Human SNP array 6.0, determined by Birdsuite and confirmed by PennCNV. They were classified as rare CNVs (found in o1% of the total sample) or common CNVs (found in X5%). PLINK was used to perform global burden analysis for rare CNVs and association analysis for common CNVs. The sample yielded 2039 rare CNVs and 79 common CNVs. Significant increases in the rare CNV burden in PD cases were not found. Common duplications in 16p11.2 showed Bonferroni-corrected P-values o0.05. Individuals with PD did not exhibit an increased genome-wide rare CNV burden. Common duplications were associated with PD and found in the pericentromeric region of 16p11.2, which had been reported to be rich in low copy repeats and to harbor developmental disorders, neuropsychiatric disorders and dysmorphic features. Keywords: 16p11.2; copy number variation; deletion; duplication; genome-wide association study; global burden analysis; Japanese; panic disorder INTRODUCTION Panic disorder (PD) is characterized by recurrent and unexpected panic attacks, subsequent anticipatory anxiety and phobic avoidance, with the frequent development of agoraphobia. 1 The lifetime prevalence of PD is 4.7% with female preponderance. 2 PD frequently takes a chronic course, with many remissions and relapses. 3 Genetic epidemiological researches including family and twin studies have shown that genetic as well as environmental factors have an important role in the pathogenesis of PD. First-degree relatives of proband with PD have a six-fold increased risk of developing the condition. 4 Twin studies show that about 40% of liability toward PD relates to heritable factors. 5 Although several linkage studies and many association studies on more than 350 candidate genes for PD have been concluded, the results were inconsistent, negative or not clearly replicated. 6 Copy number variations (CNVs) are quantitative structural variants; they are deletions and duplications of DNA segments ranging

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Replication of a genome-wide association study of panic disorder in a Japanese population

Cited by 48 publications

References 42 publications

International Union of Basic and Clinical Pharmacology. LXXXV: Calcium-Activated Chloride Channels

International Union of Basic and Clinical Pharmacology. LXXXV: Calcium-Activated Chloride Channels

The assessment and treatment of panic disorder in general practice

A genome-wide CNV association study on panic disorder in a Japanese population

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