Replication-Deficient Zika Vector-Based Vaccine Provides Maternal and Fetal Protection in Mouse Model

García, Gustavo; Chakravarty, Nikhil; Abu, Angel Elma; Jeyachandran, Arjit Vijey; Takano, Kari-Ann; Brown, Rebecca; Morizono, Kouki; Arumugaswami, Vaithilingaraja

doi:10.1128/spectrum.01137-22

Cited by 5 publications

(3 citation statements)

References 61 publications

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“…Researchers are developing various genetic modification technologies to limit the survival of mosquito vector [9]. Meanwhile, vaccines against mosquito-borne viruses are continually being developed [10,11].…”

Section: Discussionmentioning

confidence: 99%

Global Infectious Diseases in October 2022: Monthly Analysis

Luo

Sun

Yu³

et al. 2022

Zoonoses

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Infectious diseases continue to pose a major threat to worldwide public health. Infections by Coronavirus Disease 2019 have eased but continue to negatively affect international economic development. The situation of other infectious diseases, such as monkeypox and mosquito-borne diseases, became stable in October. Monitoring epidemic situation of infectious diseases can provide rapid insight into global transmission trends and assist in predicting epidemic situations. Visualizations and analyses summarizing the past few weeks of global data on major infectious diseases are provided.

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Section: Discussionmentioning

confidence: 99%

Global Infectious Diseases in October 2022: Monthly Analysis

Luo

Sun

Yu³

et al. 2022

Zoonoses

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show abstract

“…Because infants are especially susceptible to infections, maternal vaccinations for infections, such as influenza, − Zika, − and hepatitis, have been utilized to protect newborns. However, this is known to inhibit the baby’s natural antibody production. − An mRNA influenza vaccine in pregnant mice showed a significantly decreased inhibition in the newborn mice’s active immune response to influenza .…”

Section: Localized Delivery Of Rna For Women’s Healthmentioning

confidence: 99%

Messenger RNA Therapy for Female Reproductive Health

VanKeulen-Miller,

Fenton

2024

Mol. Pharmaceutics

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Female reproductive health has traditionally been an underrepresented area of research in the drug delivery sciences. This disparity is also seen in the emerging field of mRNA therapeutics, a class of medicines that promises to treat and prevent disease by upregulating protein expression in the body. Here, we review advances in mRNA therapies through the lens of improving female reproductive health. Specifically, we begin our review by discussing the fundamental structure and biochemical modifications associated with mRNA-based drugs. Then, we discuss various packaging technologies, including lipid nanoparticles, that can be utilized to protect and transport mRNA drugs to target cells in the body. Last, we conclude our review by discussing the usage of mRNA therapy for addressing pregnancy-related health and vaccination against sexually transmitted diseases in women. Of note, we also highlight relevant clinical trials using mRNA for female reproductive health while also providing their corresponding National Clinical Trial identifiers. In undertaking this review, our aim is to provide a fundamental background understanding of mRNA therapy and its usage to specifically address female health issues with an overarching goal of providing information toward addressing gender disparity in certain aspects of health research.

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“…When working with viable cells, despite the fact that the MX inside the cells remain intact, the cell membranes may be impermeable to a number of substances necessary for evaluation of mitochondrial functions, Membrane potential of MX can be assessed using membrane-penetrating cationic fluorescent or phosphorescent dyes, which are distributed in MX according to the Nernst equation, thus enabling detection of MX membrane depolarization [34]. The following fluorescent probes are used: safranin O [35], rhodamine [36], cyanines [37], DiSC2 (3) [38].…”

Section: Investigation Of Ion Channel Functionsmentioning

confidence: 99%

Application of fluorescent potential-sensitive probes for the study of living blood and marrow cells

Parkhomenko¹,

Galibin²,

Tomson³

2023

CTT

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Usage of membrane potential-sensitive probes is of great importance for assessing both the viability and functional integrity of the cells and their structural components (mitochondria, nuclei, cytoplasmic membranes, ion channels). Potential advantage of this approach includes studies of native viable cells in order to assess functional state of donor hematopoietic cells before transplantation as well as upon their storage and cultivation. These staining tools allow to assess the state of cellular bioenergetics, i.e., the balance between production and consumption of energy in living cells. The production of energy in mitochondrial structures ensures the cell viability, whereas its impairment leads to the development of different disorders and aging. The purpose of this literature review is to demonstrate the opportunities of using potential-sensitive probes to assess the viability of blood system cells and to study the state of their energy potential.

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Replication-Deficient Zika Vector-Based Vaccine Provides Maternal and Fetal Protection in Mouse Model

Cited by 5 publications

References 61 publications

Global Infectious Diseases in October 2022: Monthly Analysis

Global Infectious Diseases in October 2022: Monthly Analysis

Messenger RNA Therapy for Female Reproductive Health

Application of fluorescent potential-sensitive probes for the study of living blood and marrow cells

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