Replay and Time Compression of Recurring Spike Sequences in the Hippocampus

Nádasdy, Zoltán; Hirase, Hajime; Czurkó, András; Csicsvari, Jozsef; Buzsáki, György

doi:10.1523/jneurosci.19-21-09497.1999

Cited by 767 publications

(673 citation statements)

References 58 publications

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“…These processes would thus promote dynamic plastic changes in neuronal populations previously engaged in memory acquisition (Maquet, 2001). Consistently with this hypothesis, several animal studies have shown that neural activity expressed during waking behavior is reinstated during subsequent sleep (e.g., Wilson and McNaughton, 1994;Skaggs and McNaughton, 1996;Qin et al, 1997;Nadasdy et al, 1999;Louie and Wilson, 2001). …”

Section: Introductionmentioning

confidence: 62%

Learned material content and acquisition level modulate cerebral reactivation during posttraining rapid-eye-movements sleep

et al. 2003

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Section: Introductionmentioning

confidence: 62%

Learned material content and acquisition level modulate cerebral reactivation during posttraining rapid-eye-movements sleep

et al. 2003

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“…There is now strong evidence that hippocampal representations active during awake states are replayed during subsequent sleep states [94,139,161,206,241]. This has been taken as evidence for a hippocampal role in consolidation.…”

Section: A1 Hippocampal Representational Replaymentioning

confidence: 99%

“…For example, the information represented in the hippocampal pyramidal cells during theta really seems to be the position of the animal within a context (see above). However, the information replayed during LIA states appears to be the recently traveled routes [139,178,206]. One possibility is that what is stored in the cortical memory is a habit-based route memory [178].…”

Section: A2 Implicationsmentioning

confidence: 99%

The hippocampal debate: are we asking the right questions?

Redish

2001

Behavioural Brain Research

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For years, the debate has been: 'Is the hippocampus the cognitive map?' or 'Is the hippocampus the core of memory?' These two hypotheses derived their original power from two key experiments-the cognitive map theory from the remarkable spatial correlates seen in recordings of hippocampal pyramidal cells and the memory theory from the profound amnesias seen in the patient H.M. Both of these key experiments have been reinterpreted over the years: hippocampal cells are correlated with much more than place and H.M. is missing much more than just his hippocampus. However, both theories are still debated today. The hippocampus clearly plays a role in both navigation and memory processing. The question that must be addressed is rather: 'What is the role played by the hippocampus in the navigation and memory systems?' By looking at the navigation system as a whole, one can identify the major role played by the hippocampus as correcting for accumulation errors that occur within idiothetic navigation systems. This is most clearly experimentally evident as reorientation when an animal is lost. Carrying this over to a more general process, this becomes a role of recalling a context, bridging a contextual gap, or, in other words, it becomes a form of recognition memory. I will review recent experimental data which seems to support this theory over the more general spatial or memory theories traditionally applied to hippocampus.

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“…Recently there has been much progress in understanding the role of theta oscillations in organizing neuronal activity in animals (O' Keefe & Dostrovsky, 1971;O'Keefe & Recce, 1993;Nádasdy et al, 1999;Huerta & Lisman, 1993;Montgomery et al, 2008). This knowledge resulted in functional theories implicating theta in memory and other cognitive processes.…”

Section: Introductionmentioning

confidence: 99%

Increased mesiotemporal delta activity characterizes virtual navigation in humans

Clemens

Borbély

Weiss

et al. 2013

Neuroscience Research

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Hippocampal theta or rhythmic slow activity (RSA) occurring during exploratory behaviors and rapid-eye-movement (REM) sleep is a characteristic and well-identifiable oscillatory rhythm in animals. In contrast, controversy surrounds the existence and electrophysiological correlates of this activity in humans. Some argue that the human hippocampal theta occurs in short and phasic bursts. On the contrary, our earlier studies provide evidence that REM-dependent mesiotemporal RSA is continuous like in animals but instead of the theta it falls in the delta frequency range. Here we used a virtual navigation task in 24 epilepsy patients implanted with foramen ovale electrodes. EEG was analyzed for 1-Hz wide frequency bins up to 10 Hz according to four conditions: resting, non-learning route-following, acquisition and recall. We found progressively increasing spectral power in frequency bins up the 4 Hz across these conditions. No spectral power increase relative to resting was revealed within the traditional theta band and above in any of the navigation conditions. Thus the affected frequency bins were below the theta band and were similar to those characterizing REM sleep in our previous studies providing further indication that it is delta rather than theta that should be regarded as a human analogue of the animal RSA.NeuroscienceResearch, Volume 76, Issues 1-2, May-June 2013, Pages 67-75, DOI: 10.1016/j.neures.2013.03.004 HighlightsMesiotemporal EEG activity was assessed during a spatial task in epilepsy patients.Low frequency spectral power increased during all three navigation conditions.There was no change during task performance in the theta frequency band.Delta rather than theta should be regarded as a human analogue of animal theta. *Highlights (for review) Click here to download Highlights (for review): highlights.doc 2 AbstractHippocampal theta or rhythmic slow activity (RSA) occurring during exploratory behaviors and rapid-eye-movement (REM) sleep is a characteristic and well-identifiable oscillatory rhythm in animals. In contrast, controversy surrounds the existence and electrophysiological correlates of this activity in humans. Some argue that the human hippocampal theta occurs in short and phasic bursts. On the contrary, our earlier studies provide evidence that REMdependent mesiotemporal RSA is continuous like in animals but instead of the theta it falls in the delta frequency range. Here we used a virtual navigation task in 24 epilepsy patients implanted with foramen ovale electrodes. EEG was analyzed for 1-Hz wide frequency bins up to 10 Hz according to four conditions: resting, non-learning route-following, acquisition and recall. We found progressively increasing spectral power in frequency bins up the 4 Hz across these conditions. No spectral power increase relative to resting was revealed within the traditional theta band and above in any of the navigation conditions. Thus the affected frequency bins were below the theta band and were similar to those characterizing REM sleep in our previ...

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Replay and Time Compression of Recurring Spike Sequences in the Hippocampus

Cited by 767 publications

References 58 publications

Learned material content and acquisition level modulate cerebral reactivation during posttraining rapid-eye-movements sleep

Learned material content and acquisition level modulate cerebral reactivation during posttraining rapid-eye-movements sleep

The hippocampal debate: are we asking the right questions?

Increased mesiotemporal delta activity characterizes virtual navigation in humans

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