Replacement of the “genetic program” program

Planer, Ronald J.

doi:10.1007/s10539-013-9388-9

Cited by 12 publications

(7 citation statements)

References 17 publications

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“…Since the discovery of the lac operon, the machine model has largely dominated molecular biology 15 , and the notion of the genome serving as a “genetic program” is still relatively common 16 . Of course, abstracting biological processes to the level of circuits (Boolean or otherwise) or even programs may be a necessary step in terms of making sense of their operation.…”

Section: Introductionmentioning

confidence: 99%

Pathways to cellular supremacy in biocomputing

et al. 2019

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Synthetic biology uses living cells as the substrate for performing human-defined computations. Many current implementations of cellular computing are based on the “genetic circuit” metaphor, an approximation of the operation of silicon-based computers. Although this conceptual mapping has been relatively successful, we argue that it fundamentally limits the types of computation that may be engineered inside the cell, and fails to exploit the rich and diverse functionality available in natural living systems. We propose the notion of “cellular supremacy” to focus attention on domains in which biocomputing might offer superior performance over traditional computers. We consider potential pathways toward cellular supremacy, and suggest application areas in which it may be found.

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Section: Introductionmentioning

confidence: 99%

Pathways to cellular supremacy in biocomputing

et al. 2019

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“…La historiadora de la ciencia Lily Kay (2000) sostiene que durante la mayor parte del siglo XX hubo un extendido "discurso de la información", que estuvo motivado, en parte, por la propuesta de varias teorías formales de la 1 Los enfoques dentro de esta estrategia son muy diversos y sus virtudes y defectos no pueden ser analizados en este artículo. Ver por ejemplo los enfoques teleosemántico (Maynard Smith 2000a, 2000bJablonka 2002, Kumar 2014, instruccional (Stegmann 2005), mecanístico (Bogen y Machamer 2011, Kjosavik 2014), representacional (Shea 2007(Shea , 2011a(Shea , 2011b, semiótico (Sarkar 2004(Sarkar , 2005c, basado en signaling games (Planer 2014(Planer , 2016Calcott 2014), y biosemiótico (Emmeche 1991(Emmeche , 1999Hoffmeyer 2008), además de las propuestas ficcionalistas (Fox Keller 2003, Levy 2011) y deflacionistas (Šustar 2007).…”

Section: La Informaciónunclassified

Información Biológica: ¿la Teoría De La Información Ataca De Nuevo?

Ruiz

2019

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Resumen La literatura filosófica ha ofrecido una serie de argumentos que buscan mostrar la inadecuación conceptual de la teoría de la información para capturar el modo como el concepto se usa en biología molecular. A partir de éstos, se llegó a cierto consenso de que si acaso hay alguna forma de explicar y defender el concepto de información en biología molecular, la estrategia debe ser otra, y el debate continuó principalmente persiguiendo alternativas. Sin embargo, algunos aportes recientes parecen desafiar el consenso y revigorar la discusión en torno a la relevancia de la teoría de la información en este contexto. El objetivo de este trabajo es analizar los argumentos que condujeron a dicho consenso y examinar en qué medida estas propuestas logran vindicar la apelación a la teoría de la información. Argumentaré que incluso la propuesta más refinada en esta línea falla en vindicar la estrategia teórico-informacional y que, como consecuencia, el consenso todavía puede ser defendido.

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“…Thus, genes contain the instructions for building an organism in contrast to, say, mere environmental inputs. Despite the frequency of these statements, many philosophers and biologists argue that such comparisons are wrong-headed and ultimately misleading rather than informative (Nicholson 2014;Keller 2001;Pigliucci 2010;Boudry and Pigliucci 2013;Griffiths 2001;Planer 2014;Nijhout 1990;Moczek et al 2015;Jaeger et al 2015). The complaints are many, and I won't rehearse them all here.…”

Section: Introductionmentioning

confidence: 98%

Philosophical Perspectives on the Engineering Approach in Biology

Holm¹,

Serban

2020

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The notion of a genetic program has been widely criticized by both biologists and philosophers. But the debate has revolved around a narrow conception of what programs are and how they work, and many criticisms are linked to this same conception. To remedy this, I outline a modern and more apt idea of a program that possesses many of the features critics thought missing from programs. Moving away from over-simplistic conceptions of programs opens the way to a more fruitful interplay of ideas between the complexity of biology and our most complex engineering discipline.

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Replacement of the “genetic program” program

Cited by 12 publications

References 17 publications

Pathways to cellular supremacy in biocomputing

Pathways to cellular supremacy in biocomputing

Información Biológica: ¿la Teoría De La Información Ataca De Nuevo?

Philosophical Perspectives on the Engineering Approach in Biology

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