The effects of the refrigerant charge on the performance of a portable propane air conditioning system have been evaluated and compared to nonportable systems in which the surrounding temperatures of the evaporator and condenser are not equal. This study aims to determine the similarities and differences in the performance of the two types of propane air conditioners under different charge levels, and to serve as a source of reference for future designs of portable air conditioners. The refrigerant charge was changed from −12.3% to +30% of its normal charge at several room temperatures ranging from 20 °C to 35 °C. The performance parameters include the refrigerant temperature, mass flow rate, maximum velocity of refrigerant, maximum pressure, cooling capacity, compressor work, specific cooling capacity, and coefficient of performance of the system. It has been found that an increase in charge level was found to increase the cooling capacity, coefficient of performance, and maximum velocity of refrigerant in the system while decreasing specific cooling capacity. The increase in the charge caused a relatively insignificant rise in the maximum pressure of the system and useful work of the compressor.