Replacement of heart valves with autologous fascia lata. Surgical technique

Ionescu, Marian I.; Ross, Donald N.; Wooler, G. H.; Deac, Radu C.; Ray, Dibyendu K.

doi:10.1002/bjs.1800570609

Cited by 20 publications

(4 citation statements)

References 8 publications

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“…During the same procedure, he constructed the valve during the operation by mounting the living fascia on a Dacron-covered titanium frame in the shape of a threecusp valve [29]. He began the clinical implantation of these valves in April 1969 [31,32]. This procedure of valve construction and implantation was used in many centers worldwide for about 3 years.…”

Section: Autograft Valvesmentioning

confidence: 99%

Biological heart valves

Ciubotaru¹,

Cebotari

Tudorache

et al. 2013

Biomedizinische Technik/Biomedical Engineering

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Cardiac valvular pathologies are often caused by rheumatic fever in young adults, atherosclerosis in elderly patients, or by congenital malformation of the heart in children, in effect affecting almost all population ages. Almost 300,000 heart valve operations are performed worldwide annually. Tissue valve prostheses have certain advantages over mechanical valves such as biocompatibility, more physiological hemodynamics, and no need for life-long systemic anticoagulation. However, the major disadvantage of biological valves is related to their durability. Nevertheless, during the last decade, the number of patients undergoing biological, rather than mechanical, valve replacement has increased from half to more than three-quarters for biological implants. Continuous improvement in valve fabrication includes development of new models and shapes, novel methods of tissue treatment, and preservation and implantation techniques. These efforts are focused not only on the improvement of morbidity and mortality of the patients but also on the improvement of their quality of life. Heart valve tissue engineering aims to provide durable, "autologous" valve prostheses. These valves demonstrate adaptive growth, which may avoid the need of repeated operations in growing patients.

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Section: Autograft Valvesmentioning

confidence: 99%

Biological heart valves

Ciubotaru¹,

Cebotari

Tudorache

et al. 2013

Biomedizinische Technik/Biomedical Engineering

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“…The surgical technique has previously been described in detail (Ionescu et al, 1970). The valves were prepared at the time of operation and mounted on a metal frame in 45 and a polypropylene support in 3.…”

Section: Methodsmentioning

confidence: 99%

“…All patients had radiographic evidence of cardiomegaly, with left atrial enlargement and pulmonary venous congestion. The majority had a long history of slow but progressive deterioration and were accepted for operation with the knowledge that they formed a high risk group.The surgical technique has previously been described in detail (Ionescu et al, 1970). The valves were prepared at the time of operation and mounted on a metal frame in 45 and a polypropylene support in 3.…”

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confidence: 99%

Replacement of the mitral valve with autologous fascia lata.

Petch¹,

Somerville²,

Ross³

et al. 1974

Heart

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“…56 TYPE OF VALVE GRAFTS USED Three basically similar types of tissue grafts were used in this series. The three cusp valve grafts were made of biological tissue attached to Dacron-covered titanium frames' (lonescu et al, 1970b;Ionescu et al, 1972;Bartek, Holden, and Ionescu, 1974). Valves prepared from the patient's own fascia lata at the time of surgery, under sterile conditions, were used in 80 cases (25 in the aortic, 52 in the mitral, and 3 in the tricuspid position).…”

mentioning

confidence: 99%

Replacement of heart valves with frame-mounted tissue grafts

Ionescu

Pakrashi

Mary

et al. 1974

Thorax

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patients had heart valve replacement with frame-mounted autologous or homologous fascia lata or with heterologous pericardial grafts. There were 111 single aortic, 95 single mitral, and seven tricuspid valve replacements.The incidence of hospital and late mortality was each 10% for the entire series and the main causes were myocardial failure and infective endocarditis.The majority of patients obtained significant symptomatic improvement. In patients with aortic replacement there was a statistically significant reduction in cardiothoracic ratio and in the voltage of the electrocardiogram.Regurgitant murmurs developed in 11 6y% of aortic patients and in 51'6% after mitral replacement (in 37-5 % the murmur has not increased in intensity while in 14-1 % it has gradually progressed). None of these mitral patients requires reoperation. Grafts in the tricuspid position have not shown signs of dysfunction or failure. Graft failure has not occurred in the aortic replacement series. From the mitral position six grafts have been removed due to failure. All six were made of autologous fascia and all showed varying degrees of thickening and retraction of cusps. There were six episodes of peripheral embolization (five transient) and one left atrial thrombosis. All seven patients are alive. Anticoagulants were not used.The results of haemodynamic studies and in vitro hydrodynamic experiments are discussed and an explanation for graft dysfunction in the mitral position is presented.The actuarial analysis of this series of patients over a period of up to 54 months postoperatively has shown encouraging results.

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Replacement of heart valves with autologous fascia lata. Surgical technique

Cited by 20 publications

References 8 publications

Biological heart valves

Biological heart valves

Replacement of the mitral valve with autologous fascia lata.

Replacement of heart valves with frame-mounted tissue grafts

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