Replacement of dietary saturated with unsaturated fatty acids is associated with beneficial effects on lipidome metabolites: a secondary analysis of a randomized trial

Sellem, Laury; Eichelmann, Fabian; Jackson, Kim G.; Wittenbecher, Clemens; Schulze, Matthias B.; Lovegrove, Julie A.

doi:10.1016/j.ajcnut.2023.03.024

Cited by 10 publications

(2 citation statements)

References 58 publications

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“…Studies have now shown that some foods have the potential to improve lipid profiles, such as synbiotics ( 77 ) and probiotics ( 78 ) from yogurt or dairy. Several randomized controlled trials have also reported that improved dietary structure or food items can effectively improve serum lipid levels in patients with cardiovascular disease ( 77 – 79 ). However, no study has yet assessed both dietary fat intakes and serum lipids with ovarian cancer risk.…”

Section: Discussionmentioning

confidence: 99%

Dietary fats and serum lipids in relation to the risk of ovarian cancer: a meta-analysis of observational studies

Zhang,

Ding,

Deng

et al. 2023

Front. Nutr.

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Although numerous epidemiological studies investigated the association between dietary fat intakes or serum lipid levels and ovarian cancer risk, a consistent and explicit conclusion for specific dietary fats or serum lipids that increase the risk of ovarian cancer is not available. In this study, a systematic review and meta-analysis were conducted to assess the key dietary fats and serum lipids that increased the risk of ovarian cancer. Databases such as PubMed, Web of Science, and EMBASE were searched for observational studies. A total of 41 studies met the inclusion criteria, including 18 cohort and 23 case–control studies (109,507 patients with ovarian cancer and 2,558,182 control/non-ovarian cancer participants). Higher dietary intakes of total fat (RR = 1.19, 95% CI = 1.06–1.33, I2 = 60.3%), cholesterol (RR = 1.14, 95% CI = 1.03–1.26, I2 = 19.4%), saturated fat (RR = 1.13, 95% CI = 1.04–1.22, I2 = 13.4%), and animal fat (RR = 1.21, 95% CI = 1.01–1.43, I2 = 70.5%) were significantly associated with a higher risk of ovarian cancer. A higher level of serum triglycerides was accompanied by a higher risk of ovarian cancer (RR = 1.33, 95% CI = 1.02–1.72, I2 = 89.3%). This meta-analysis indicated that a higher daily intake of total fat, saturated fat, animal fat, and cholesterol and higher levels of serum triglycerides were significantly associated with an increased risk of ovarian cancer.

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Section: Discussionmentioning

confidence: 99%

Dietary fats and serum lipids in relation to the risk of ovarian cancer: a meta-analysis of observational studies

Zhang,

Ding,

Deng

et al. 2023

Front. Nutr.

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“…Similarly, circulating ceramides were also lower in another study, reducing general circulating ceramide content but C16:0 and lowering general inflammatory status ( 120 ). Another clinical trial observed that subjects eating a diet high in unsaturated fatty acids had reduced plasmatic fatty acids containing sphingolipids than subjects eating a diet high in saturated fatty acids ( 103 ). However, none of these human studies analyzed hepatic status.…”

Section: Experimental/clinical Evidence Of Therapies Targeting Sphing...mentioning

confidence: 99%

Therapeutic implications for sphingolipid metabolism in metabolic dysfunction-associated steatohepatitis

Ramos-Molina,

Rossell,

Pérez-Montes de Oca

et al. 2024

Front. Endocrinol.

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The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), a leading cause of chronic liver disease, has increased worldwide along with the epidemics of obesity and related dysmetabolic conditions characterized by impaired glucose metabolism and insulin signaling, such as type 2 diabetes mellitus (T2D). MASLD can be defined as an excessive accumulation of lipid droplets in hepatocytes that occurs when the hepatic lipid metabolism is totally surpassed. This metabolic lipid inflexibility constitutes a central node in the pathogenesis of MASLD and is frequently linked to the overproduction of lipotoxic species, increased cellular stress, and mitochondrial dysfunction. A compelling body of evidence suggests that the accumulation of lipid species derived from sphingolipid metabolism, such as ceramides, contributes significantly to the structural and functional tissue damage observed in more severe grades of MASLD by triggering inflammatory and fibrogenic mechanisms. In this context, MASLD can further progress to metabolic dysfunction-associated steatohepatitis (MASH), which represents the advanced form of MASLD, and hepatic fibrosis. In this review, we discuss the role of sphingolipid species as drivers of MASH and the mechanisms involved in the disease. In addition, given the absence of approved therapies and the limited options for treating MASH, we discuss the feasibility of therapeutic strategies to protect against MASH and other severe manifestations by modulating sphingolipid metabolism.

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Isoliquiritigenin in combination with visceral adipose tissue and related markers as a predictive tool for nonalcoholic fatty liver disease

Mogna-Peláez,

Romo-Hualde,

Riezu-Boj

et al. 2023

J Physiol Biochem

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Nonalcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease in the world. New non-invasive diagnostic tools are needed to promptly treat this disease and avoid its complications. This study aimed to find key metabolites and related variables that could be used to predict and diagnose NAFLD. Ninety-eight subjects with NAFLD and 45 controls from the Fatty Liver in Obesity (FLiO) Study (NCT03183193) were analyzed. NAFLD was diagnosed and graded by ultrasound and classified into two groups: 0 (controls) and ≥ 1 (NAFLD). Hepatic status was additionally assessed through magnetic resonance imaging (MRI), elastography, and determination of transaminases. Anthropometry, body composition (DXA), biochemical parameters, and lifestyle factors were evaluated as well. Non-targeted metabolomics of serum was performed with high-performance liquid chromatography coupled to time-of-flight mass spectrometry (HPLC-TOF-MS). Isoliquiritigenin (ISO) had the strongest association with NAFLD out of the determinant metabolites. Individuals with higher concentrations of ISO had healthier metabolic and hepatic status and were less likely to have NAFLD (OR 0.13). Receiver operating characteristic (ROC) curves demonstrated the predictive power of ISO in panel combination with other NAFLD and IR-related variables, such as visceral adipose tissue (VAT) (AUROC 0.972), adiponectin (AUROC 0.917), plasmatic glucose (AUROC 0.817), and CK18-M30 (AUROC 0.810). Individuals with lower levels of ISO have from 71 to 82% more risk of presenting NAFLD compared to individuals with higher levels. Metabolites such as ISO, in combination with visceral adipose tissue, IR, and related markers, constitute a potential non-invasive tool to predict and diagnose NAFLD.

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Replacement of dietary saturated with unsaturated fatty acids is associated with beneficial effects on lipidome metabolites: a secondary analysis of a randomized trial

Cited by 10 publications

References 58 publications

Dietary fats and serum lipids in relation to the risk of ovarian cancer: a meta-analysis of observational studies

Dietary fats and serum lipids in relation to the risk of ovarian cancer: a meta-analysis of observational studies

Therapeutic implications for sphingolipid metabolism in metabolic dysfunction-associated steatohepatitis

Isoliquiritigenin in combination with visceral adipose tissue and related markers as a predictive tool for nonalcoholic fatty liver disease

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