Repetitive transcranial magnetic stimulation treatment for depressive disorders

Baeken, Chris; Brem, Anna‐Katharine; Arns, Martijn; Brunoni, André R.; Filipčić, Igor; Ganho-Ávila, Ana; Langguth, Berthold; Padberg, Frank; Poulet, Emmanuel; Rachid, Fady; Sack, Alexander T.; Vanderhasselt, Marie‐Anne; Bennabi, Djamila

doi:10.1097/yco.0000000000000533

Cited by 76 publications

(41 citation statements)

References 54 publications

(49 reference statements)

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“…Beside pharmacotherapy and psychotherapy brain stimulation methods have gained increasing relevance in the treatment of depression during the last decades (28). Electric convulsive therapy (ECT) is an established antidepressant method with clearly proven efficacy for fast improvement of suicidal behavior, however, the use of ECT is limited by safety concerns and adverse effects (29).…”

Section: Introductionmentioning

confidence: 99%

Anti-Suicidal Efficacy of Repetitive Transcranial Magnetic Stimulation in Depressive Patients: A Retrospective Analysis of a Large Sample

et al. 2020

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Background: Suicide is a major public health problem. About 90% of suicide victims have one or more major psychiatric disorder, with a reported 20-fold increased risk for suicide in patients with affective disorders in comparison with healthy subjects. Repetitive transcranial magnetic stimulation (rTMS) has been established as an effective alternative or adjunctive treatment option for patients with depressive disorders, but little is known about its effects on suicide risk. Objective: For the assessment of the effectiveness of rTMS on suicidal ideation and behaviors, we performed a retrospective analysis of a large sample of patients with depressive disorders, who were treated with rTMS. Methods: We analyzed the records of 711 TMS in-and outpatients with depressive affective disorders in a tertiary referral hospital between 2002 and 2017. Out of these patients we were able to collect Hamilton depression rating scale (HAMD) data of 332 patients (180 females, 152 males; age range 20 to 79 years; mean age 47.3 ± 12.3) for which we analyzed the change of suicidal ideation by using item 3 (suicidality) of HAMD. Results: Out of all 711 patients treated with rTMS for their depression, one patient (0.1%) committed suicide during the TMS treatment. In the statistical analysis of the subsample with 332 patients there was an overall amelioration of depressive symptoms accompanied by a significant decrease in the suicidality item with a medium effect size. Decrease in suicidality was not inferior to changes in other items as indicated by effect sizes. Fortyseven percent of patients showed an amelioration in suicidality, 41.3% of patients did not show a change in their suicidality's scores, and 11.7% of patients showed an increase in suicidality's scores from baseline to final rating. Correlation of item 3 (suicidality) and item 7 (drive) demonstrated a significant positive association, revealing improved drive with a parallel decreased suicidality. Conclusion: Based on the proposed data, there is no evidence that rTMS increases the risk for suicide during the course of the treatment. Conversely, rTMS tends to reduce

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Section: Introductionmentioning

confidence: 99%

Anti-Suicidal Efficacy of Repetitive Transcranial Magnetic Stimulation in Depressive Patients: A Retrospective Analysis of a Large Sample

et al. 2020

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“…The burden of mood and stress‐related disorders on both individuals and society has been assuming alarming proportions for decades, yet relatively little progress is being made regarding treatment efficacy. Although noninvasive brain stimulation techniques such as (repetitive) transcranial magnetic stimulation (rTMS) have been showing promising effects on stress regulation and mood improvement in both neuroscientific as well as clinical contexts (Baeken et al, 2019; Blumberger et al, 2018b; Chen, Chang, Chen, & Lin, 2013; Lefaucheur et al, 2020), a growing number of studies report substantial interindividual variability in responsiveness toward TMS, as its working mechanisms are not yet fully understood (Kapur, Phillips, & Insel, 2012; López‐Alonso, Cheeran, Río‐Rodríguez, & Fernández‐del‐Olmo, 2014). Inconsistencies in responsiveness may reflect individual differences in neurophysiological processes underlying its mechanisms on the stress response.…”

Section: Introductionmentioning

confidence: 99%

Individual resting‐state frontocingular functional connectivity predicts the intermittent theta burst stimulation response to stress in healthy female volunteers

Wandel

Pulopulos

Labanauskas

et al. 2020

Human Brain Mapping

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Intermittent theta burst stimulation (iTBS) delivered to the dorsolateral prefrontal cortex (DLPFC) has been investigated as a promising treatment for stress and stressrelated mental disorders such as major depression, yet large individual differences in responsiveness demand further exploration and optimization of its effectiveness. Clinical research suggests that resting-state functional connectivity (rsFC) between the DLPFC and the anterior cingulate cortex (ACC) can predict iTBS treatment response in depression. The present study aimed to investigate whether rsFC between the left DLPFC and ACC subregions could predict the degree to which the stress system is affected by iTBS. After assessment of baseline resting-state fMRI data, 34 healthy female participants performed the Trier Social Stress Test on two separate days, each followed by active or sham iTBS over the left DLPFC. To evaluate iTBS effects on the stress-system, salivary cortisol was measured throughout the procedure. Our results showed that a stronger negative correlation between the left DLPFC and the caudal ACC was linked to a larger attenuation of stress-system sensitivity during active, but not during sham iTBS. In conclusion, based on individual rsFC between left DLPFC and caudal ACC, iTBS could be optimized to more effectively attenuate deregulation of the stress system.

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“…4e shows the induced electric field gradient of repetitive MTI (rMTI) where we apply a gradient pulse every second to the deep brain region. Repetitive transcranial magnetic stimulation has been extensively researched in the past two decades and it has been widely shown that this technique can be very effective for the treatment of major depression disorder, Parkinson's disease, and stroke [14,15,16,17]. Fig.…”

Section: Field Strength Validation Of Mti Technique For Neural Stimulmentioning

confidence: 99%

Magnetic Temporal Interference For Noninvasive, High-resolution, and Localized Deep Brain Stimulation: Concept Validation

Zaeimbashi

Khalifa

Dong

et al. 2020

Preprint

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Non-invasive deep brain stimulation has been a major challenge in the field of neuroscience and brain stimulation in the past three decades. Current brain stimulation technologies suffer from such hurdles as the inability to do deep brain stimulation, poor spatial resolution, and invasiveness. Transcranial magnetic stimulation (TMS) technique, for instance, cannot target brain regions deeper than ∼2cm and has a poor spatial resolution, impacting a large area of the peripheral region and leading to various side effects. Implantable electrodes, even though effective for deep brain stimulation, are invasive and carry various drawbacks related to the surgery and site infection. In this paper, we propose a new concept that relies on temporal interference of two high- frequency magnetic fields generated by two electromagnetic coils. The neural system does not respond to each of these high-frequency magnetic fields alone because of the intrinsic low-pass filtering properties of the neural membrane. The peripheral areas of the brain are impacted only by the high-frequency magnetic fields that cannot stimulate the nerves, while the deep brain area where the two fields interfere experiences a magnetic field that contains a low-frequency envelope and therefore the nerves can be stimulated. This technique can noninvasively focus a magnetic or electric beam at any depth inside the brain with a high resolution, without impacting the peripheral regions.

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Repetitive transcranial magnetic stimulation treatment for depressive disorders

Cited by 76 publications

References 54 publications

Anti-Suicidal Efficacy of Repetitive Transcranial Magnetic Stimulation in Depressive Patients: A Retrospective Analysis of a Large Sample

Anti-Suicidal Efficacy of Repetitive Transcranial Magnetic Stimulation in Depressive Patients: A Retrospective Analysis of a Large Sample

Individual resting‐state frontocingular functional connectivity predicts the intermittent theta burst stimulation response to stress in healthy female volunteers

Magnetic Temporal Interference For Noninvasive, High-resolution, and Localized Deep Brain Stimulation: Concept Validation

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