Repetitive transcranial magnetic stimulation: Re-wiring the alcoholic human brain

Diana, Marco; Bolloni, Corinna; Antonelli, Massimo; Giuda, Daniela Di; Cocciolillo, Fabrizio; Fattore, Liana; Addolorato, Giovanni

doi:10.1016/j.alcohol.2018.05.011

Cited by 12 publications

(5 citation statements)

References 179 publications

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“…Although outside the scope of the present review, it is worth noting that other nonpharmacological approaches that may have therapeutic value in AUD include repetitive transcranial magnetic stimulation, transcranial direct current stimulation, and deep brain stimulation. For a more in-depth discussion of these therapeutic interventions, please see [245][246][247][248].…”

Section: Psychological and Non-pharmacological Therapies For Audmentioning

confidence: 99%

Alcohol Use Disorder: Neurobiology and Therapeutics

et al. 2022

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Alcohol use disorder (AUD) encompasses the dysregulation of multiple brain circuits involved in executive function leading to excessive consumption of alcohol, despite negative health and social consequences and feelings of withdrawal when access to alcohol is prevented. Ethanol exerts its toxicity through changes to multiple neurotransmitter systems, including serotonin, dopamine, gamma-aminobutyric acid, glutamate, acetylcholine, and opioid systems. These neurotransmitter imbalances result in dysregulation of brain circuits responsible for reward, motivation, decision making, affect, and the stress response. Despite serious health and psychosocial consequences, this disorder still remains one of the leading causes of death globally. Treatment options include both psychological and pharmacological interventions, which are aimed at reducing alcohol consumption and/or promoting abstinence while also addressing dysfunctional behaviours and impaired functioning. However, stigma and social barriers to accessing care continue to impact many individuals. AUD treatment should focus not only on restoring the physiological and neurological impairment directly caused by alcohol toxicity but also on addressing psychosocial factors associated with AUD that often prevent access to treatment. This review summarizes the impact of alcohol toxicity on brain neurocircuitry in the context of AUD and discusses pharmacological and non-pharmacological therapies currently available to treat this addiction disorder.

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Section: Psychological and Non-pharmacological Therapies For Audmentioning

confidence: 99%

Alcohol Use Disorder: Neurobiology and Therapeutics

et al. 2022

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“…Finally, emerging data in humans suggests that targeting the mPFC 38 – 40 could reduce craving and intake in patients diagnosed with a substance use disorder 41 , 42 . Thus, we used a chemogenetic approach to stimulate neurons in dmPFC to test the hypothesis that increasing dmPFC activity would reduce compulsive drinking.…”

Section: Introductionmentioning

confidence: 99%

Compulsive alcohol drinking in rodents is associated with altered representations of behavioral control and seeking in dorsal medial prefrontal cortex

Timme

Linsenbardt

et al. 2022

Nat Commun

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A key feature of compulsive alcohol drinking is continuing to drink despite negative consequences. To examine the changes in neural activity that underlie this behavior, compulsive alcohol drinking was assessed in a validated rodent model of heritable risk for excessive drinking (alcohol preferring (P) rats). Neural activity was measured in dorsal medial prefrontal cortex (dmPFC—a brain region involved in maladaptive decision-making) and assessed via change point analyses and novel principal component analyses. Neural population representations of specific decision-making variables were measured to determine how they were altered in animals that drink alcohol compulsively. Compulsive animals showed weakened representations of behavioral control signals, but strengthened representations of alcohol seeking-related signals. Finally, chemogenetic-based excitation of dmPFC prevented escalation of compulsive alcohol drinking. Collectively, these data indicate that compulsive alcohol drinking in rats is associated with alterations in dmPFC neural activity that underlie diminished behavioral control and enhanced seeking.

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“…With these methods, we tested the hypothesis that representations of behavioral control signals are weakened in dmPFC during compulsive drinking. Finally, emerging data in humans suggests that targeting the mPFC 30-32 could reduce craving and intake in patients diagnosed with a substance use disorder 33, 34 . Thus, we used a chemogenetic approach to stimulate neurons in dmPFC to test the hypothesis that increasing dmPFC activity would reduce compulsive drinking, which would support the view that circuit manipulations that restore dmPFC function are potentially novel treatments for AUD.…”

Section: Introductionmentioning

confidence: 99%

Compulsive drinking is associated with neural activity patterns reflecting diminished behavioral control and enhanced seeking representations in dorsal medial prefrontal cortex

Timme

Linsenbardt

et al. 2021

Preprint

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Drinking despite negative consequences (compulsive drinking) is a central contributor to high-risk alcohol intake and is associated with poor treatment outcomes in humans. We used a rodent model of compulsive drinking to examine the role played by dorsal medial prefrontal cortex (dmPFC), a brain region involved in maladaptive decision-making in addiction, in this clinically critical phenomenon. We developed novel advances in principal component and change point analyses to dissect neural population representations of specific decision-making variables. Compulsive subjects showed weakened representations of behavioral control signals that relate to drinking within a trial, but strengthened session-wide seeking state representations that were associated with drinking engagement at the start of each drinking opportunity. Finally, chemogenetic-based excitation of dmPFC prevented escalation of compulsive drinking. Collectively, these data indicate that compulsive drinking is associated with alterations in dmPFC neural activity that underlie diminished behavioral control and enhanced seeking.

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Repetitive transcranial magnetic stimulation: Re-wiring the alcoholic human brain

Cited by 12 publications

References 179 publications

Alcohol Use Disorder: Neurobiology and Therapeutics

Alcohol Use Disorder: Neurobiology and Therapeutics

Compulsive alcohol drinking in rodents is associated with altered representations of behavioral control and seeking in dorsal medial prefrontal cortex

Compulsive drinking is associated with neural activity patterns reflecting diminished behavioral control and enhanced seeking representations in dorsal medial prefrontal cortex

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