Repetitive Transcranial Magnetic Stimulation of the Brain After Ischemic Stroke: Mechanisms from Animal Models

Xing, Ying; Zhang, Yuqian; Li, Congqin; Hua, Yan; Hu, Jian; Bai, Yulong

doi:10.1007/s10571-022-01264-x

Cited by 14 publications

(7 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings harmonize with existing evidence that high‐frequency rTMS heightens GluA1 levels and promotes the insertion of AMPARs into synapses. However, prior investigations have positioned NMDARs and AMPARs as the principal receptors underpinning rTMS effects, 27 the involvement of NMDARs in rTMS‐induced neuronal plasticity remains a possibility. Yet, the amplitudes of NMDAR‐mediated mEPSCs and eEPSCs remained unperturbed in our results.…”

Section: Discussionmentioning

confidence: 99%

Integrin α3 is required for high‐frequency repetitive transcranial magnetic stimulation‐induced glutamatergic synaptic transmission in mice with ischemia

Liu,

Hu,

et al. 2023

CNS Neurosci Ther

View full text Add to dashboard Cite

BackgroundRepetitive transcranial magnetic stimulation (rTMS) is an effective therapy in post‐stroke motor recovery. However, the underlying mechanisms of rTMS regulates long‐lasting changes with synaptic transmission and glutamate receptors function (including AMPARs or NMDARs) remains unclear.MethodsMice were received 10‐Hz rTMS treatment once daily on the third day after photothrombotic (PT) stroke for 18 days. Motor behaviors and the Western blot were used to evaluate the therapeutic efficacy of 10‐Hz rTMS in the mice with PT model. Moreover, we used wild‐type (WT) and NEX‐α3−/− mice to further explore the 10‐Hz rTMS effect.ResultsWe found that 10‐Hz rTMS improved the post‐stroke motor performance in the PT mice. Moreover, the levels of AMPAR, vGlut1, and integrin α3 in the peri‐infarct were significantly increased in the rTMS group. In contrast, 10‐Hz rTMS did not induce these aforementioned effects in NEX‐α3−/− mice. The amplitude of AMPAR‐mediated miniature excitatory postsynaptic currents (EPSCs) and evoked EPSCs was increased in the WT + rTMS group, but did not change in NEX‐α3−/− mice with rTMS.ConclusionsIn this study, 10‐Hz rTMS improved the glutamatergic synaptic transmission in the peri‐infract cortex through effects on integrin α3 and AMPARs, which resulted in motor function recovery after stroke.

show abstract

Section: Discussionmentioning

confidence: 99%

Integrin α3 is required for high‐frequency repetitive transcranial magnetic stimulation‐induced glutamatergic synaptic transmission in mice with ischemia

Liu,

Hu,

et al. 2023

CNS Neurosci Ther

View full text Add to dashboard Cite

show abstract

“…rTMS can promote synaptic plasticity and thus induce neurological recovery by increasing the expression of NMDAR, AMPAR, and BDNF. 132 Recent research has shown that stroke patients exhibit significant improvements in movement disorders, motor function, and quality of life after rTMS, 133,134…”

Section: Rehab Ilitati On Ther Apy To Improve Synap Tic Dys Fun C Tionmentioning

confidence: 99%

“…Repetitive transcranial magnetic stimulation (rTMS) also has positive effects in animal models of ischemic stroke. rTMS can promote synaptic plasticity and thus induce neurological recovery by increasing the expression of NMDAR, AMPAR, and BDNF 132 . Recent research has shown that stroke patients exhibit significant improvements in movement disorders, motor function, and quality of life after rTMS, 133,134 but whether this approach improves patient outcomes by affecting synaptic function requires further research.…”

Section: Rehabilitation Therapy To Improve Synaptic Dysfunctionmentioning

confidence: 99%

Current evidence of synaptic dysfunction after stroke: Cellular and molecular mechanisms

Li,

Jiang,

Fang

et al. 2024

CNS Neurosci Ther

View full text Add to dashboard Cite

BackgroundStroke is an acute cerebrovascular disease in which brain tissue is damaged due to sudden obstruction of blood flow to the brain or the rupture of blood vessels in the brain, which can prompt ischemic or hemorrhagic stroke. After stroke onset, ischemia, hypoxia, infiltration of blood components into the brain parenchyma, and lysed cell fragments, among other factors, invariably increase blood–brain barrier (BBB) permeability, the inflammatory response, and brain edema. These changes lead to neuronal cell death and synaptic dysfunction, the latter of which poses a significant challenge to stroke treatment.ResultsSynaptic dysfunction occurs in various ways after stroke and includes the following: damage to neuronal structures, accumulation of pathologic proteins in the cell body, decreased fluidity and release of synaptic vesicles, disruption of mitochondrial transport in synapses, activation of synaptic phagocytosis by microglia/macrophages and astrocytes, and a reduction in synapse formation.ConclusionsThis review summarizes the cellular and molecular mechanisms related to synapses and the protective effects of drugs or compounds and rehabilitation therapy on synapses in stroke according to recent research. Such an exploration will help to elucidate the relationship between stroke and synaptic damage and provide new insights into protecting synapses and restoring neurologic function.

show abstract

“…Repetitive TMS (rTMS) has been used as an alternative treatment for various neurological disorders, usually when other treatments are ineffective ( Lefaucheur et al, 2020 ). Although, the molecular mechanisms underlying TMS-induced neurorecovery have been systematically studied in rodent models ( Xing et al, 2022 ), most TMS studies in rodents were based on the whole brain stimulation with the commercial coils ( Roth et al, 2007 ; Vahabzadeh-Hagh et al, 2012 ; Guerra et al, 2020 ). The lack of rodent-specific focal TMS coils restricts the proper translation of human TMS protocols to animal models.…”

Section: Introductionmentioning

confidence: 99%

Design and evaluation of a rodent-specific focal transcranial magnetic stimulation coil with the custom shielding application in rats

Liu

Ding

et al. 2023

Front. Neurosci.

Self Cite

View full text Add to dashboard Cite

Repetitive TMS has been used as an alternative treatment for various neurological disorders. However, most TMS mechanism studies in rodents have been based on the whole brain stimulation, the lack of rodent-specific focal TMS coils restricts the proper translation of human TMS protocols to animal models. In this study, we designed a new shielding device, which was made of high magnetic permeability material, to enhance the spatial focus of animal-use TMS coils. With the finite element method, we analyzed the electromagnetic field of the coil with and without the shielding device. Furthermore, to assess the shielding effect in rodents, we compared the c-fos expression, the ALFF and ReHo values in different groups following a 15 min 5 Hz rTMS paradigm. We found that a smaller focality with an identical core stimulation intensity was achieved in the shielding device. The 1 T magnetic field was reduced from 19.1 mm to 13 mm in diameter, and 7.5 to 5.6 mm in depth. However, the core magnetic field over 1.5 T was almost the same. Meanwhile, the area of electric field was reduced from 4.68 cm2 to 4.19 cm2, and 3.8 mm to 2.6 mm in depth. Similar to this biomimetic data, the c-fos expression, the ALFF and ReHo values showed more limited cortex activation with the use of the shielding device. However, compared to the rTMS group without the shielding application, more subcortical regions, like the striatum (CPu), the hippocampus, the thalamus, and the hypothalamus were also activated in the shielding group. This indicated that more deep stimulation may be achieved by the shielding device. Generally, compared with the commercial rodents’ TMS coil (15 mm in diameter), TMS coils with the shielding device achieved a better focality (~6 mm in diameter) by reducing at least 30% of the magnetic and electric field. This shielding device may provide a useful tool for further TMS studies in rodents, especially for more specific brain area stimulation.

show abstract

Repetitive Transcranial Magnetic Stimulation of the Brain After Ischemic Stroke: Mechanisms from Animal Models

Cited by 14 publications

References 79 publications

Integrin α3 is required for high‐frequency repetitive transcranial magnetic stimulation‐induced glutamatergic synaptic transmission in mice with ischemia

Integrin α3 is required for high‐frequency repetitive transcranial magnetic stimulation‐induced glutamatergic synaptic transmission in mice with ischemia

Current evidence of synaptic dysfunction after stroke: Cellular and molecular mechanisms

Design and evaluation of a rodent-specific focal transcranial magnetic stimulation coil with the custom shielding application in rats

Contact Info

Product

Resources

About