Repetitive Transcranial Magnetic Stimulation of the Primary Somatosensory Cortex Modulates Perception of the Tendon Vibration Illusion

Huh, D; Lee, J. M.; Oh, Sung Min; Jh, Lee; Donkelaar, Paul; Lee, D. H.

doi:10.1177/0031512516663715

Cited by 6 publications

(7 citation statements)

References 52 publications

(69 reference statements)

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“…Thus, providing further support that face SI plays a specific role in the processing of PD of the face. The neural basis of inhibitory mechanisms induced by cTBS is still under active investigations [30]. It can be speculated that cTBS applied to face SI produces lasting changes in the excitability of the intracortical circuits generating somatosensory evoked potentials (SEPs) by inducing long-term depression-like synaptic plasticity in SI [31].…”

Section: Discussionmentioning

confidence: 99%

Effect of repetitive transcranial magnetic stimulation on altered perception of One’s own face

et al. 2020

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Background: Chronic orofacial pain (COP) patients often perceive the painful face area as "swollen" without clinical signs; such self-reported illusions of the face are termed perceptual distortion (PD). The pathophysiological mechanisms underlying PD remain elusive. Objective: To test the neuromodulatory effect of repetitive transcranial magnetic stimulation (rTMS) on PD in healthy individuals, to gain insight into the cortical mechanisms underlying PD. Methods: PD was induced experimentally by injections of local anesthetic (LA) around the infraorbital nerve and measured as perceived size changes of the affected area. Participants were randomly allocated to inhibitory rTMS (n ¼ 26) or sham rTMS (n ¼ 26) group. The participants rated PD at baseline, 6 min after LA, immediately, 20 and 40 min after rTMS. The rTMS (inhibitory and sham) was applied to face (lip) representation area of primary somatosensory cortex (SI) as an intervention at 10 min after the LA, when the magnitude of PD is large. As inhibitory rTMS, continuous theta-burst stimulation paradigm (50 Hz) for 40s was employed to inhibit cortical activity. Results: We demonstrated a significant decrease in the magnitude of PD immediately and 20 min after the application of inhibitory rTMS compared with sham rTMS (P < 0.006). In two control experiments, we also showed that peripheral muscle stimulation and stimulation of a cortical region other than the lip representation area had no effect on the magnitude of the PD. Conclusions: Inhibitory rTMS applied to a somatotopical-relevant cortical region modulates PD of the face in healthy individuals and could potentially have therapeutic implications for COP patients.

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Section: Discussionmentioning

confidence: 99%

Effect of repetitive transcranial magnetic stimulation on altered perception of One’s own face

et al. 2020

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“…Immediately after the pre-test, each subject’s quadriceps muscle representation on the motor cortex was identified by the Rapid 2 TMS system (Magstim, UK). The magnitude of the EMG signal elicited by the TMS was monitored, and the stimulation site with the greatest EMG signal was chosen as described by Huh et al10 ) .…”

Section: Methodsmentioning

confidence: 99%

“…This artificial motor neuron activation has been reported to persist following application9 ) . Pietrosimone et al10 ) showed a decrease in AMI for 60 minutes following a single pulse of TMS, when applied to the primary motor cortex.…”

Section: Introductionmentioning

confidence: 99%

Benefits of using transcranial magnetic stimulation as a tool to facilitate the chronic knee injury rehabilitation

Jae-Moo

Lee

2017

J Phys Ther Sci

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[Purpose] While primary motor cortex activation has been implicated as a key factor in the arthrogenic muscle inhibition after knee joint injury, no viable rehabilitation protocol has been developed to accommodate this factor. In this study, transcranial magnetic stimulation was applied as a means of dissipating arthrogenic muscle inhibition by introducing temporary motor cortex excitation prior to the rehabilitation. [Subjects and Methods] Twenty-four subjects who have underwent the surgery due to knee injury were recruited, and randomly assigned to the control or the simulation groups. The levels of electromyography signals during the maximum voluntary contraction of the quadriceps muscle before, during, and after training designed for the quadriceps strength rehabilitation were measured. [Results] When compared to controls, subjects who received the transcranial magnetic stimulations showed significantly increased levels of voluntary muscle contraction after the training. Moreover, the beneficial effect of the stimulation increased as the rehabilitation progressed. [Conclusion] Transcranial magnetic stimulation itself does not directly improve the symptoms related to knee injuries. However, the use of this technique can provide a time window for effective intervention by dissipating the unwanted effect of the arthrogenic muscle inhibition during rehabilitation.

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“…TMS over S1 has been extensively used to determine its effect on kinesthetic perception 17 or in motor learning. 18 These studies, however, used coils with different size that may pose variable range of influence on the adjacent area of the cortex.…”

Section: Introductionmentioning

confidence: 99%

Navigated transcranial magnetic stimulation of the primary somatosensory cortex evokes motor potentials in healthy humans’ flexor carpi radialis muscle - A pilot study

Négyesi

Mori

Ataka

et al. 2020

BJMB

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Background: Although previous studies targeted S1 by TMS to investigate its effect on the corticospinal pathway, there is no evidence if such stimuli produced by TMS would distinctly be restricted to it and not reach M1 interneurons adjacent to S1.Aim: We hypothesized that S1 vs. M1 stimulation-induced MEPs would be similar but smaller and less variable due to the focality of the magnetic pulse, considering that even if TMS is neuronavigated, the magnetic field is not selective enough and reaches M1 interneurons.Method: Healthy volunteers (n = 8, 2 females, age: 29.9 ± 5.49y) received single-pulse TMS over each hemisphere at each intensity of 90, 100, 110, and 120% of rMT in a randomized order. MEPs from the contralateral FCR were recorded.Results: We found no interhemispheric differences, but larger peak-to-peak amplitudes and variability of MEPs after M1 as compared to S1 stimulation. However, latency and waveforms of MEPs did not differ between S1 vs. M1 stimulation supporting the idea that TMS over S1 is not selective enough and can excite M1 interneurons thus producing MEPs on the contralateral FCR.Interpretation: Future studies should carefully consider these results when targeting S1 with TMS even if using a neuronavigation system.

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Repetitive Transcranial Magnetic Stimulation of the Primary Somatosensory Cortex Modulates Perception of the Tendon Vibration Illusion

Cited by 6 publications

References 52 publications

Effect of repetitive transcranial magnetic stimulation on altered perception of One’s own face

Effect of repetitive transcranial magnetic stimulation on altered perception of One’s own face

Benefits of using transcranial magnetic stimulation as a tool to facilitate the chronic knee injury rehabilitation

Navigated transcranial magnetic stimulation of the primary somatosensory cortex evokes motor potentials in healthy humans’ flexor carpi radialis muscle - A pilot study

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