Repetitive transcranial magnetic stimulation of the supplementary motor area (SMA) degrades bimanual movement control in humans

Serrien, Deborah J.; Strens, Lucy H. A.; Oliviero, Antonio; Brown, Peter

doi:10.1016/s0304-3940(02)00499-8

Cited by 158 publications

(112 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…that might influence subjects to organize a sequence in a specific way. It has recently been shown that medial frontal TMS can disrupt various aspects of bimanual coordination (Obhi et al 2002;Serrien et al 2002;Steyvers et al 2003), suggesting that the disruptive effects of pre-SMA TMS in our study may be attributed to the use of bimanual sequences rather than the demands of organizing sequences. However, there are several lines of evidence that suggest the medial frontal region isn't limited to bimanual tasks but that this region may have a more abstract role in the organization and performance of complex actions (Picard and Strick 1996).…”

Section: Specificity Of Tms Application Over the Pre-smamentioning

confidence: 45%

Organization of Action Sequences and the Role of the Pre-SMA

Kennerley¹,

Sakai²,

Rushworth³

2004

Journal of Neurophysiology

193

175

View full text Add to dashboard Cite

Kennerley, Steve W., K. Sakai, and M.F.S. Rushworth. Organization of action sequences and the role of the pre-SMA. J Neurophysiol 91: 978-993, 2004. First published October 22, 2003 10.1152/jn.00651.2003. To understand the contribution of the human presupplementary motor area (pre-SMA) in sequential motor behavior, we performed a series of finger key-press experiments. Experiment 1 revealed that each subject had a spontaneous tendency to organize or "chunk" a long sequence into shorter components. We hypothesized that the pre-SMA might have a special role in initiating each chunk but not at other points during the sequence. Experiment 2 therefore examined the effect of 0.5-s, 10-Hz repetitive transcranial magnetic stimulation (rTMS) directed over the pre-SMA. As hypothesized, performance was disrupted when rTMS was delivered over the pre-SMA at the beginning of the second chunk but not when it was delivered in the middle of a chunk. Contrary to the hypothesis, TMS did not disrupt sequence initiation. Experiments 3 and 4 examined whether the very first movement of a sequence could be disrupted under any circumstances. Pre-SMA TMS did disrupt the initiation of sequences but only when subjects had to switch between sequences and when the first movement of each sequence was not covertly instructed by a learned visuomotor association. In conjunction, the results suggest that for overlearned sequences the pre-SMA is primarily concerned with the initiation of a sequence or sequence chunk and the role of the pre-SMA in sequence initiation is only discerned when subjects must retrieve the sequence from memory as a superordinate set of movements without the aid of a visuomotor association. Control experiments revealed such effects were not present when rTMS was applied over the left dorsal premotor cortex.

show abstract

Section: Specificity Of Tms Application Over the Pre-smamentioning

confidence: 45%

Organization of Action Sequences and the Role of the Pre-SMA

Kennerley¹,

Sakai²,

Rushworth³

2004

Journal of Neurophysiology

193

175

View full text Add to dashboard Cite

show abstract

“…Lesions of SMA-proper in monkeys (Brinkman, 1984) and disruptive TMS of the SMA-proper in humans impair particularly the performance of bimanual motor tasks (Obhi et al, 2002;Serrien et al, 2002;Steyvers et al, 2003) and intermanual transfer of procedural knowledge (Perez et al, 2008). On the other hand, preparatory neuronal activity for unimanual movements starts off with bilateral activation of the SMA-proper (Shibasaki and Hallett, 2006).…”

Section: Topographic Specificity Of Pas-induced Plasticity In the Smamentioning

confidence: 99%

State-Dependent and Timing-Dependent Bidirectional Associative Plasticity in the Human SMA-M1 Network

Arai¹,

Müller‐Dahlhaus²,

Murakami³

et al. 2011

J. Neurosci.

114

105

View full text Add to dashboard Cite

The supplementary motor area (SMA-proper) plays a key role in the preparation and execution of voluntary movements. Anatomically, SMA-proper is densely reciprocally connected to primary motor cortex (M1), but neuronal coordination within the SMA-M1 network and its modification by external perturbation are not well understood. Here we modulated the SMA-M1 network using MR-navigated multicoil associative transcranial magnetic stimulation in healthy subjects. Changes in corticospinal excitability were assessed by recording motor evoked potential (MEP) amplitude bilaterally in a hand muscle. We found timing-dependent bidirectional Hebbian-like MEP changes during and for at least 30 min after paired associative SMA-M1 stimulation. MEP amplitude increased if SMA stimulation preceded M1 stimulation by 6 ms, but decreased if SMA stimulation lagged M1 stimulation by 15 ms. This associative plasticity in the SMA-M1 network was highly topographically specific because paired associative stimulation of pre-SMA and M1 did not result in any significant MEP change. Furthermore, associative plasticity in the SMA-M1 network was strongly state-dependent because it required priming by near-simultaneous M1 stimulation to occur. We conclude that timing-dependent bidirectional associative plasticity is demonstrated for the first time at the systems level of a human corticocortical neuronal network. The properties of this form of plasticity are fully compatible with spike-timing-dependent plasticity as defined at the cellular level. The necessity of priming may reflect the strong interhemispheric connectivity of the SMA-M1 network. Findings are relevant for better understanding reorganization and potentially therapeutic modification of neuronal coordination in the SMA-M1 network after cerebral lesions such as stroke.

show abstract

“…upplementary motor area (SMA) has been found to play a dominant role in motor planning, preparation, and control (Babiloni et al, 2003;Brinkman, 1981;Cunnington et al, 2002;Jenkins et al, 2000;Nair et al, 2003;Serrien et al, 2002;Tanji and Shima, 1994), while the primary motor cortex (M1) directly participates in movement execution (Haaland and Harrington, 1996;Nair et al, 2003;Porro et al, 1996). Thereby, these two areas have been consistently found to be significantly activated during both motor execution and motor imagery tasks (Gao et al, 2011;Gerardin et al, 2000;Guillot et al, 2008;Hanakawa et al, 2003;Jeannerod, 1994;Michelon et al, 2006;Solodkin et al, 2004;Szameitat et al, 2007).…”

mentioning

confidence: 99%

Differential Contribution of Bilateral Supplementary Motor Area to the Effective Connectivity Networks Induced by Task Conditions Using Dynamic Causal Modeling

et al. 2014

View full text Add to dashboard Cite

Functional imaging studies have indicated hemispheric asymmetry of activation in bilateral supplementary motor area (SMA) during unimanual motor tasks. However, the hemispherically special roles of bilateral SMAs on primary motor cortex (M1) in the effective connectivity networks (ECN) during lateralized tasks remain unclear. Aiming to study the differential contribution of bilateral SMAs during the motor execution and motor imagery tasks, and the hemispherically asymmetric patterns of ECN among regions involved, the present study used dynamic causal modeling to analyze the functional magnetic resonance imaging data of the unimanual motor execution/imagery tasks in 12 right-handed subjects. Our results demonstrated that distributions of network parameters underlying motor execution and motor imagery were significantly different. The variation was mainly induced by task condition modulations of intrinsic coupling. Particularly, regardless of the performing hand, the task input modulations of intrinsic coupling from the contralateral SMA to contralateral M1 were positive during motor execution, while varied to be negative during motor imagery. The results suggested that the inhibitive modulation suppressed the overt movement during motor imagery. In addition, the left SMA also helped accomplishing left hand tasks through task input modulation of left SMA/right SMA connection, implying that hemispheric recruitment occurred when performing nondominant hand tasks. The results specified differential and altered contributions of bilateral SMAs to the ECN during unimanual motor execution and motor imagery, and highlighted the contributions induced by the task input of motor execution/imagery.

show abstract

Repetitive transcranial magnetic stimulation of the supplementary motor area (SMA) degrades bimanual movement control in humans

Cited by 158 publications

References 13 publications

Organization of Action Sequences and the Role of the Pre-SMA

Organization of Action Sequences and the Role of the Pre-SMA

State-Dependent and Timing-Dependent Bidirectional Associative Plasticity in the Human SMA-M1 Network

Differential Contribution of Bilateral Supplementary Motor Area to the Effective Connectivity Networks Induced by Task Conditions Using Dynamic Causal Modeling

Contact Info

Product

Resources

About