Repetitive transcranial magnetic stimulation is as effective as electroconvulsive therapy in the treatment of nondelusional major depressive disorder: an open study

Grunhaus, Leon; Dannon, Pinhas N.; Schreiber, Shaul; Dolberg, Ornah H; Amiaz, Revital; R, Ziv; Lefkifker, E.

doi:10.1016/s0006-3223(99)00254-1

Cited by 282 publications

(179 citation statements)

References 33 publications

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“…4 5 Several clinical parameters might affect treatment success, such as the absence of psychosis, age, and/or length of the current depressive episode. 23,[46][47][48][49] In our study, neither gender, age, depression severity, 50 nor duration of the current episode predicted successful outcome.…”

Section: Discussioncontrasting

confidence: 83%

HF-rTMS Treatment in Medication-Resistant Melancholic Depression:Results from¹⁸FDG-PET Brain Imaging

Baeken¹,

Raedt

Hove³

et al. 2009

CNS spectr.

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Section: Discussioncontrasting

confidence: 83%

HF-rTMS Treatment in Medication-Resistant Melancholic Depression:Results from¹⁸FDG-PET Brain Imaging

Baeken¹,

Raedt

Hove³

et al. 2009

CNS spectr.

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“…Our report of an acute occurrence of psychotic symptoms in response to rTMS is also in favor of an rTMS-induced increase in dopaminergic activity (Zwanzger et al, 2002). Accordingly, rTMS was reported to have better effects in nonpsychotic as compared to psychotic major depression (Grunhaus et al, 2000). In the latter condition, a dopaminergic hyperactivity is thought to play a crucial role.…”

Section: Mesolimbic Dopaminergic System As a Therapeutic Target For Rmentioning

confidence: 51%

Repetitive Transcranial Magnetic Stimulation Increases the Release of Dopamine in the Nucleus Accumbens Shell of Morphine-Sensitized Rats During Abstinence

Erhardt

Sillaber

Welt

et al. 2004

Neuropsychopharmacol

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Recent studies in rodents have shown that withdrawal from chronic drug abuse is associated with a significant decrease in dopamine (DA) release in mesolimbic structures, especially in the shell region of the nucleus accumbens. Since the DA system is known to play an important role in reward processes, a withdrawal-associated impairment in mesolimbic DA-mediated transmission could possibly implicate reward deficit and thus enhance vulnerability to drug craving and relapse. We have previously demonstrated that acute repetitive transcranial magnetic stimulation (rTMS) has a modulatory effect on DA release in several areas of the rat brain, including dorsal striatum, hippocampus, and nucleus accumbens shell. In the present study, we investigated the possible use of rTMS as a tool in reestablishing the dysregulated DA secretion observed during withdrawal in morphine-sensitized male Sprague-Dawley rats. Using intracerebral microdialysis, we monitored the effects of acute rTMS (20 Hz) on the intra-accumbal release-patterns of DA in freely moving animals that were subjected to a morphine sensitization scheme for a period of 8 days. We provide first evidence that acute rTMS (20 Hz) is able to increase DA concentration in the shell region of the nucleus accumbens in both control animals and morphinesensitized rats during abstinence. The DA release in morphine-sensitized rats was significantly higher than in controls. rTMS, therefore, might gain a potential therapeutic role in the treatment of dysphoric and anhedonic states during drug withdrawal in humans.

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“…For instance, Grunhaus et al randomly assigned 40 inpatients to treatment with up to 4 weeks of daily, left DLPFC rTMS or 2.5 x seizure threshold, right unilateral ECT. 16 Both treatments had similar efficacy among nonpsychotic patients (approximately 60% response rate). However, ECT was strikingly superior among psychotically depressed patients.…”

Section: Rtms Versus Ectmentioning

confidence: 91%

Terapias somáticas para transtornos psiquiátricos resistentes ao tratamento

Braga

Petrides²

2007

Rev. Bras. Psiquiatr.

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A b s t r a c t Objective: This paper reviews the current knowledge of somatic treatment in psychiatry, with a focus on treatment-resistant psychiatric disorders. Method: A computerized search of the literature was conducted on Medline using the words "electroconvulsive therapy", "transcranial magnetic stimulation", "vagus nerve stimulation", "deep brain stimulation", and "magnetic seizure therapy". References from each paper were also screened. Results: The development of new non-pharmacological psychiatric interventions in the past decades has renewed the clinical and research interest in somatic therapies. Although electroconvulsive therapy remains the only somatic treatment with undisputed efficacy; transcranial magnetic stimulation, vagus nerve stimulation and deep brain stimulation all offer potential as novel means of psychiatric treatment. Conclusions: New treatment modalities still have an insufficient body of data. Notwithstanding, biological strategies continue to hold promise as a safer and more effective approach to psychiatric treatment. Descriptors: Brain diseases; Electroconvulsive therapy; Transcranial magnetic stimulation; Vagus nerve; Deep brain stimulationResumo Objetivo: O presente artigo é uma revisão do conhecimento atual relativo às terapias somáticas em psiquiatria, com foco em transtornos psiquiátricos resistentes ao tratamento usual. Método: Foi realizada uma pesquisa computadorizada da literatura no Medline utilizando as palavras "eletroconvulsoterapia", "estimulação magnética transcraniana ", "terapia magnética convulsiva", "estimulação do nervo vago" e "estimulação cerebral profunda", com todos os termos traduzidos para o idioma inglês. Referên-cias listadas em cada artigo foram também analisadas. Resultados: O desenvolvimento de novos tratamentos psiquiátricos não farmacológicos nas últimas décadas renovou o interesse em terapias somáticas. A despeito de a eletroconvulsoterapia continuar a ser o único tratamento somático com eficácia estabelecida, a estimulação magnética transcraniana, a terapia magnética convulsiva, a estimulação do nervo vago e a estimulação cerebral profunda são potencialmente novas modalidades de tratamento psiquiátrico. Conclusões: Novas modalidades de tratamento ainda padecem de falta de conhecimento cientifico adequado. Entretanto, estratégias somáticas ainda representam uma promessa como formas mais eficazes e seguras de tratamento psiquiátrico.

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Repetitive transcranial magnetic stimulation is as effective as electroconvulsive therapy in the treatment of nondelusional major depressive disorder: an open study

Cited by 282 publications

References 33 publications

HF-rTMS Treatment in Medication-Resistant Melancholic Depression:Results from¹⁸FDG-PET Brain Imaging

HF-rTMS Treatment in Medication-Resistant Melancholic Depression:Results from¹⁸FDG-PET Brain Imaging

Repetitive Transcranial Magnetic Stimulation Increases the Release of Dopamine in the Nucleus Accumbens Shell of Morphine-Sensitized Rats During Abstinence

Terapias somáticas para transtornos psiquiátricos resistentes ao tratamento

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Repetitive transcranial magnetic stimulation is as effective as electroconvulsive therapy in the treatment of nondelusional major depressive disorder: an open study

Cited by 282 publications

References 33 publications

HF-rTMS Treatment in Medication-Resistant Melancholic Depression:Results from18FDG-PET Brain Imaging

HF-rTMS Treatment in Medication-Resistant Melancholic Depression:Results from18FDG-PET Brain Imaging

Repetitive Transcranial Magnetic Stimulation Increases the Release of Dopamine in the Nucleus Accumbens Shell of Morphine-Sensitized Rats During Abstinence

Terapias somáticas para transtornos psiquiátricos resistentes ao tratamento

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HF-rTMS Treatment in Medication-Resistant Melancholic Depression:Results from¹⁸FDG-PET Brain Imaging

HF-rTMS Treatment in Medication-Resistant Melancholic Depression:Results from¹⁸FDG-PET Brain Imaging