Repetitive transcranial magnetic stimulation induces different responses in different cortical areas: a functional magnetic resonance study in humans

Kemna, Lars J.; Gembris, Daniel

doi:10.1016/s0304-3940(02)01195-3

Cited by 35 publications

(40 citation statements)

References 17 publications

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“…In the case of the spinal location, 2 groups have suggested that the mechanism producing motor region BOLD is the action of afferents returning signal from the affected muscle. 11,12 Our data do not rule out this possibility. However, the paired-pulse TMS results of some investigators strongly suggest localized synaptic activity based on latencies displayed in EMG data.…”

Section: Discussioncontrasting

confidence: 58%

“…11,12 In summary, the results reported here demonstrate that the levels of within-subject variability in location of BOLD response can be smaller in magnitude than the dimensions of typical cortical gyri. This level of precision is great enough to suggest that TMS placement could be guided reliably for targeting of specific brain anatomy within functional regions and anatomic structures.…”

Section: Discussionmentioning

confidence: 62%

“…2,4,5 These factors have led to growing interest in combining TMS with functional imaging methods to explore brain circuitry. [6][7][8][9][10][11][12] Both positron emission tomography and functional magnetic resonance imaging (fMRI) observations have shown similarity in the brain's responses to TMS and cognitive tasks. 6,7,9,10,13 However, the relations among cortical response locations, TMS coil locations, and specific cortical anatomy are not yet precisely described.…”

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confidence: 99%

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A High Resolution Assessment of the Repeatability of Relative Location and Intensity of Transcranial Magnetic Stimulation–induced and Volitionally Induced Blood Oxygen Level–dependent Response in the Motor Cortex

Denslow¹,

Lomarev²,

Bohning³

et al. 2004

Cognitive and Behavioral Neurology

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Section: Discussioncontrasting

confidence: 58%

Section: Discussionmentioning

confidence: 62%

mentioning

confidence: 99%

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A High Resolution Assessment of the Repeatability of Relative Location and Intensity of Transcranial Magnetic Stimulation–induced and Volitionally Induced Blood Oxygen Level–dependent Response in the Motor Cortex

Denslow¹,

Lomarev²,

Bohning³

et al. 2004

Cognitive and Behavioral Neurology

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“…4,[42][43][44] If reafference were a predominant source of BOLD signal, two separate cortical areas, which both elicit thumb motion, might result in similar BOLD locations due primarily to afferents from the hand rather than to direct TMS action. The differences we have observed in time courses may result from variation in the proportion of reafferent signal contributing to BOLD production.…”

Section: Bold Location Patternsmentioning

confidence: 99%

An Increased Precision Comparison of TMS-Induced Motor Cortex BOLD fMRI Response for Image-Guided Versus Function-Guided Coil Placement

Denslow¹,

Bohning²,

Böhning³

et al. 2005

Cognitive and Behavioral Neurology

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Objective: To examine with high precision the differences between function-guided and image-guided transcranial magnetic stimulation (TMS).Method: Using a calibrated TMS coil holder/positioner, interleaved TMS/functional magnetic resonance imaging (fMRI), and individualized anatomy-based regional normalization, we conducted a twophase study of TMS coil positioning guided by either function (elicited thumb motion) or image-based targeting of the ''hand knob,'' the anatomy associated with fMRI activation during thumb motion.Results: In every case, image-guided TMS coil placement produced a thumb movement response at thresholds similar to those found under function guidance. Unexpectedly, function-guided coil locations clustered bimodally over central and precentral sulci. Imageguided locations clustered as anticipated toward the targeted gyral crown. Despite these differences, blood oxygenation level-dependent (BOLD) activation locations and magnitude for the two methods displayed no consistent differences in mean or variance between or within subjects. Image guidance produced more consistent coil placement from subject to subject relative to targeted anatomy. Surprisingly, BOLD time courses from image-guided experiments showed significantly slower return to baseline after TMS than was observed under function guidance. Conclusions:The results demonstrate the effectiveness and precision of image-guided positioning of TMS coils combined with a precisely adjustable holder/positioner and regional normalization.Image guidance provides an accurate TMS placement relative to individual anatomy when no external sign is available.

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“…One way to assess such remote effects is through the combination of TMS with functional MRI (fMRI) (Baudewig et al, 2001;Bestmann et al, 2003aBestmann et al, , 2004Bohning, 1998;Bohning et al, 1997Bohning et al, , 1999Shastri et al, 1999). One frequent observation in such studies is that TMS can elicit activity changes in cortical and subcortical brain regions that are putatively interconnected with the cortical stimulation site (Bestmann et al, 2004(Bestmann et al, , 2005Baudewig et al, 2001;Blankenburg et al, 2008Blankenburg et al, , 2010Bohning, 1998;Bohning et al, 1999;Denslow et al, 2005;Kemna and Gembris, 2003;Li et al, 2004a;Moisa et al, 2012;Ruff et al, 2008).…”

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confidence: 99%

A Setup for Administering TMS to Medial and Lateral Cortical Areas During Whole-Brain fMRI Recording

Weijer

Sommer

Bakker

et al. 2014

Journal of Clinical Neurophysiology

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Stimulating brain areas with transcranial magnetic stimulation (TMS) while concurrently and noninvasively recording brain activity changes through functional MRI enables a new range of investigations about causal interregional interactions in the human brain. However, standard head-coil arrangements for current methods for concurrent TMS-functional MRI somewhat restrict the cortical brain regions that can be targeted with TMS because space in typical MR head coils is limited. Another limitation for concurrent TMS-functional MRI approaches concerns the estimation of the precise stimulation site, which can limit the interpretation of the activity changes induced by TMS and increase the variability of the stimulation effects. Here, we present a novel approach using flexible MR receiver coils, allowing for stimulation of a large part of the cortex including more lateral areas. Furthermore, we present a fast and economical method to determine the precise location of the stimulation coil during scanning. This point-based registration method can accurately compute, during scanning, where TMS pulses are delivered. We validated this approach by stimulating medial (M1) and more lateral (dorsal part of the supramarginal gyrus) brain areas concurrently with functional MRI. Activation close to but not directly at the stimulated location and in distal areas connected to the targeted site was observed. This study provides a proof of concept that TMS of medial and lateral brain areas is feasible without significantly compromising brain coverage and that one can precisely determine the exact coil location inside the bore to verify targeting of brain areas.

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Repetitive transcranial magnetic stimulation induces different responses in different cortical areas: a functional magnetic resonance study in humans

Cited by 35 publications

References 17 publications

A High Resolution Assessment of the Repeatability of Relative Location and Intensity of Transcranial Magnetic Stimulation–induced and Volitionally Induced Blood Oxygen Level–dependent Response in the Motor Cortex

A High Resolution Assessment of the Repeatability of Relative Location and Intensity of Transcranial Magnetic Stimulation–induced and Volitionally Induced Blood Oxygen Level–dependent Response in the Motor Cortex

An Increased Precision Comparison of TMS-Induced Motor Cortex BOLD fMRI Response for Image-Guided Versus Function-Guided Coil Placement

A Setup for Administering TMS to Medial and Lateral Cortical Areas During Whole-Brain fMRI Recording

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