Repetitive transcranial magnetic stimulation increases the release of dopamine in the mesolimbic and mesostriatal system

Keck, Martin E.; Welt, Tobias; Müller, Marianne B.; Erhardt, Angelika; Ohl, Frauke; Toschi, Nicola; Holsboer, Florian; Sillaber, Inge

doi:10.1016/s0028-3908(02)00069-2

Cited by 281 publications

(173 citation statements)

References 55 publications

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“…(1) DA-potentiating drugs (eg, Swift, 2010) and (2) rTMS (eg, Keck et al, 2002;Feil and Zangen, 2010). Although DA-containing neurons are located deeply in the brainstem, making them inaccessible to direct rTMS stimuli, DA neurons may be reached indirectly through neurons located elsewhere in the brain.…”

Section: Future Research Directions: Transcranial Magnetic Stimulationmentioning

confidence: 99%

Novel Therapeutic Strategies for Alcohol and Drug Addiction: Focus on GABA, Ion Channels and Transcranial Magnetic Stimulation

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Leggio

Hopf

et al. 2011

Neuropsychopharmacol

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Drug addiction represents a major social problem where addicts and alcoholics continue to seek and take drugs despite adverse social, personal, emotional, and legal consequences. A number of pharmacological compounds have been tested in human addicts with the goal of reducing the level or frequency of intake, but these pharmacotherapies have often been of only moderate efficacy or act in a sub-population of humans. Thus, there is a tremendous need for new therapeutic interventions to treat addiction. Here, we review recent interesting studies focusing on gamma-aminobutyric acid receptors, voltage-gated ion channels, and transcranial magnetic stimulation. Some of these treatments show considerable promise to reduce addictive behaviors, or the early clinical studies or pre-clinical rationale suggest that a promising avenue could be developed. Thus, it is likely that within a decade or so, we could have important new and effective treatments to achieve the goal of reducing the burden of human addiction and alcoholism.

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Section: Future Research Directions: Transcranial Magnetic Stimulationmentioning

confidence: 99%

Novel Therapeutic Strategies for Alcohol and Drug Addiction: Focus on GABA, Ion Channels and Transcranial Magnetic Stimulation

Addolorato

Leggio

Hopf

et al. 2011

Neuropsychopharmacol

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“…rTMS was applied exactly as described before (eg Czeh et al, 2002;Keck et al, 2000bKeck et al, , 2002Müller et al, 2000). A commercially available stimulator (MagProt, DANTEC/ Medtronic, Skovlunde, Denmark) was used.…”

Section: Repetitive Transcranial Magnetic Stimulationmentioning

confidence: 99%

“…One way to address these problems is to calculate the spatial distribution of current density induced in both the rat and human brain and to adjust the stimulation parameters accordingly. The coil and stimulation parameters used in the studies conducted at our laboratory were selected according to an exact characterization of the conductive phenomena elicited by rTMS in both human and rat brain (eg Keck et al, 2000aKeck et al, , b, 2001Keck et al, , 2002Czeh et al, 2002). This enabled us to accurately adapt the experimental setup in order to achieve a stimulation pattern that is analogous to the one used in patients during standard clinical treatment.…”

Section: Rtms In Rat Studiesmentioning

confidence: 99%

Repetitive Transcranial Magnetic Stimulation Increases the Release of Dopamine in the Nucleus Accumbens Shell of Morphine-Sensitized Rats During Abstinence

Erhardt

Sillaber

Welt

et al. 2004

Neuropsychopharmacol

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Recent studies in rodents have shown that withdrawal from chronic drug abuse is associated with a significant decrease in dopamine (DA) release in mesolimbic structures, especially in the shell region of the nucleus accumbens. Since the DA system is known to play an important role in reward processes, a withdrawal-associated impairment in mesolimbic DA-mediated transmission could possibly implicate reward deficit and thus enhance vulnerability to drug craving and relapse. We have previously demonstrated that acute repetitive transcranial magnetic stimulation (rTMS) has a modulatory effect on DA release in several areas of the rat brain, including dorsal striatum, hippocampus, and nucleus accumbens shell. In the present study, we investigated the possible use of rTMS as a tool in reestablishing the dysregulated DA secretion observed during withdrawal in morphine-sensitized male Sprague-Dawley rats. Using intracerebral microdialysis, we monitored the effects of acute rTMS (20 Hz) on the intra-accumbal release-patterns of DA in freely moving animals that were subjected to a morphine sensitization scheme for a period of 8 days. We provide first evidence that acute rTMS (20 Hz) is able to increase DA concentration in the shell region of the nucleus accumbens in both control animals and morphinesensitized rats during abstinence. The DA release in morphine-sensitized rats was significantly higher than in controls. rTMS, therefore, might gain a potential therapeutic role in the treatment of dysphoric and anhedonic states during drug withdrawal in humans.

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“…The effect of transcranial magnetic stimulation on Dopamine released in hippocampus, nucleus accumbens and striatum of adult male rats was detected by microdialysis in brain. The results suggested that transcranial magnetic stimulation can significantly increased dopamine concentrations in the hippocampus, nucleus accumbens, and striatum [7]. Transcranial magnetic stimulation activates dopaminergic neurons in PD rat model.…”

Section: Animal Studymentioning

confidence: 87%

The Theory of Brain Cell Activation

Sun¹

2017

UCMS

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This is a new idea that based on effective treatment of Parkinson's disease and Alzheimer's disease with transcranial magnetoelectric stimulation technology. It is a hypothesis that Voltage gated Ca 2+ channels can activate the best target by Physical means. Basic content: neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease, are closely related to voltage-gated calcium channels. The key method of treatment is activation of neurotransmitter neurons. Voltage gated Ca 2+ channels are the best target for activation by physical means. The aim is to induce calcium influx to trigger synaptic vesicles released from axon terminals and release neurotransmitters. The theory of brain cell activation sets forth the principle, method and purpose of treatment of the physical gated ion channel diseases such as Alzheimer's disease, Parkinson's disease and other neural degeneration diseases, and indicates that the attempt to treat these diseases using pharmaceutical and chemical approaches could shake our confidence in conquering the diseases, and the application of physical approaches or combined application of physical and chemical approaches in the treatment of some major encephalopathy may be our main research direction in the future.

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Repetitive transcranial magnetic stimulation increases the release of dopamine in the mesolimbic and mesostriatal system

Cited by 281 publications

References 55 publications

Novel Therapeutic Strategies for Alcohol and Drug Addiction: Focus on GABA, Ion Channels and Transcranial Magnetic Stimulation

Novel Therapeutic Strategies for Alcohol and Drug Addiction: Focus on GABA, Ion Channels and Transcranial Magnetic Stimulation

Repetitive Transcranial Magnetic Stimulation Increases the Release of Dopamine in the Nucleus Accumbens Shell of Morphine-Sensitized Rats During Abstinence

The Theory of Brain Cell Activation

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