Repetitive transcranial magnetic stimulation for cognitive function in adults with bipolar disorder: A pilot study

McIntyre, Roger S.; Lee, Yena; Rodrigues, Nelson B.; Nasri, Flora; Lao, Guohui; Zeng, Wan; Ye, Biru; Li, Ripeng; Rosenblat, Joshua D.; Mansur, Rodrigo B.; Subramaniapillai, Mehala; Lui, Leanna M.W.; Teopiz, Kayla M.; Liu, Tao; Xiong, Jiaqi; Zhang, Ruoxi; Lu, Weicong; Xu, Gaixia; Xiong, Hui; Lin, Kangguang

doi:10.1016/j.jad.2021.05.075

Cited by 9 publications

(13 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, detailed measurement data for 9 trials were inaccessible, leaving 21 RCTs for quantitative analysis. The 9 inaccessible trails were investigating adjunctive effect of N-acetylcysteine (NAC), 21 melatonin, 22 methylene blue, 23 pramipexole, 24 repetitive TMS (rTMS), 25 docosahexaenoic acid (DHA), 26 and atorvastatin 27 among euthymic BD patients; and adjunctive tDCS, 28 olanzapine, 29 for depressed BD patients. Across these 21 trials for quantitative analysis, 42 cognitive tests were used to assess intervention effects on the 8 domains.…”

Section: Systematic Literature Reviewmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Pharmacological and Neurostimulation Interventions for Cognitive Domains in Patients with Bipolar Disorder: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

Chen¹,

Liu²,

Cheng³

et al. 2021

CLEP

View full text Add to dashboard Cite

Section: Systematic Literature Reviewmentioning

confidence: 99%

“…26,27 The only promising findings came from the most recently published pilot study for rTMS targeting cognitive function in BD, which indicating a significant group by time interaction in verbal learning domain. 25…”

Section: Systematic Literature Reviewmentioning

confidence: 99%

Effect of Pharmacological and Neurostimulation Interventions for Cognitive Domains in Patients with Bipolar Disorder: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

Chen¹,

Liu²,

Cheng³

et al. 2021

CLEP

View full text Add to dashboard Cite

“…Finally, a recently published (not included in the above review) pilot RCT (McIntyre et al. 2021 ) showed a significant improvement in verbal learning in active (N = 16) versus sham (N = 20) rTMS.…”

Section: Resultsmentioning

confidence: 99%

Neurocognitive functioning in bipolar disorder: What we know and what we don’t

Keramatian

Yatham

2021

Dialogues in Clinical Neuroscience

View full text Add to dashboard Cite

Introduction: This narrative review of systematic reviews and meta-analyses aims at compiling available evidence in various aspects of neurocognitive functioning in Bipolar Disorder (BD). Methods: We conducted a MEDLINE literature search and identified 38 relevant systematic reviews and metaanalyses. Results: Current evidence suggests that BD is associated with cognitive impairment across multiple domains and during all clinical states. However, there is a considerable cognitive heterogeneity within BD, which cannot be explained by clinical subtypes, and the pattern of neurocognitive impairment in BD overlaps with other psychiatric conditions such as major depression and schizophrenia. Residual depressive symptoms, poor clinical course and higher number of manic episodes may negatively impact cognitive performance, which is a major predictor of general functioning in BD. Evidence from available prospective studies does not support the notion of progressive cognitive decline in BD while some evidence exists to suggest patients may show some improvements in cognitive functioning following the first manic episode. Furthermore, a subset of patients may show premorbid cognitive abnormalities that could signal an early neurodevelopmental aetiology. Preliminary findings from small studies identify potential pro-cognitive effects of Cognitive Remediation, erythropoietin, intranasal insulin, lurasidone, mifepristone, repetitive Transcranial Magnetic Stimulation and transcranial Direct Current Stimulation in BD. Discussion: Longitudinal studies in high-risk individuals can provide a better understanding of the development and progression of neurocognitive impairment in BD. Largescale randomised control trials are needed to compare the pro-cognitive efficacy of various pharmacological and non-pharmacological interventions in different cognitive subgroups of patients at different stages of BD.

show abstract

“…All cognitive outcomes improved regardless of the treatment group, suggesting that dTMS was neither associated with adverse nor beneficial cognitive effects. A pilot RCT comparing rTMS ( n = 16) to sham treatment plus stable pharmacotherapy ( n = 20) during a non‐acute state found significant improvement in verbal learning in the rTMS group, but no group differences in other cognitive measures 30 . The largest RCT of rTMS in euthymic patients ( n = 52) found improved cognitive function across multiple measures relative to sham treatment 104 …”

Section: Transcranial Magnetic Stimulationmentioning

confidence: 99%

“…Cognitive function is critical to daily functioning and an important component of treatment response, given that many individuals with bipolar disorders show cognitive impairment 29 . However, pharmacological treatments are primarily targeted towards the improvement of mood symptoms, and few treatments improve cognitive dysfunction 30 . As such, there is a need to improve existing treatments and develop novel therapeutic options that are safe, effective and improve other features of bipolar disorders, including cognitive dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Brain stimulation treatment for bipolar disorder

Mutz

2022

Bipolar Disorders

View full text Add to dashboard Cite

Aims Bipolar disorders are clinically complex, chronic and recurrent disorders. Few treatment options are effective across hypomanic, manic, depressive and mixed states and as continuation or maintenance treatment after initial symptom remission. The aim of this review was to provide an up‐to‐date overview of research on the efficacy, tolerability and cognitive effects of electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), magnetic seizure therapy (MST), deep brain stimulation (DBS) and vagus nerve stimulation (VNS). Methods References included in this review were identified through multiple searches of the Embase, PubMed/MEDLINE and APA PsycINFO electronic databases for articles published from inception until February 2022. Published reviews, meta‐analyses, randomised controlled trials and recent studies were prioritised to provide a comprehensive and up‐to‐date overview of research on brain stimulation in patients with bipolar disorders. Results The evidence base for brain stimulation as an add‐on or alternative to pharmacological and psychological treatments in patients with bipolar disorders is limited but rapidly expanding. Brain stimulation treatments represent an opportunity to treat all bipolar disorder states, including cognitive dysfunction during euthymic periods. Conclusion Whilst findings to date have been encouraging, larger randomised controlled trials with long‐term follow‐up are needed to clarify important questions regarding treatment efficacy and tolerability, the frequency of treatment‐emergent affective switches and effects on cognitive function.

show abstract

Repetitive transcranial magnetic stimulation for cognitive function in adults with bipolar disorder: A pilot study

Cited by 9 publications

References 21 publications

Effect of Pharmacological and Neurostimulation Interventions for Cognitive Domains in Patients with Bipolar Disorder: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

Effect of Pharmacological and Neurostimulation Interventions for Cognitive Domains in Patients with Bipolar Disorder: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

Neurocognitive functioning in bipolar disorder: What we know and what we don’t

Brain stimulation treatment for bipolar disorder

Contact Info

Product

Resources

About