Repetitive transcranial magnetic stimulation for tinnitus

Meng, Zhaoli; Liu, Shixi; Zheng, Yun; Phillips, John S.

doi:10.1002/14651858.cd007946.pub2

Cited by 94 publications

(72 citation statements)

References 75 publications

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“…A systematic review assessed fi ve trials that compared this technique with a control, all with nonnavigated coil localisation. 57 The fi ndings showed limited support for use of low-frequency transcranial magnetic stimulation to reduce tinnitus volume or improve quality of life. Each trial described the use of a diff erent device that delivered diff erent waveforms at diff erent stimulation rates; interpretation of the fi ndings is diffi cult, because the various stimulation protocols were diff erentially benefi cial for tinnitus.…”

Section: Brain Stimulationmentioning

confidence: 97%

“…Consequently, with the exception of CBT, 43,44 evidence for the eff ectiveness of diff erent treat ment strategies is insuffi cient. 40,47,57,67,98 Investigators under taking a UK-wide consultation of patients and clinicians made a priority list of ten unanswered questions (panel), 99,100 many of which could be addressed through high-quality randomised controlled trials.…”

Section: Clinical Trials In Tinnitusmentioning

confidence: 99%

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Tinnitus

Baguley¹,

McFerran²,

Hall³

2013

The Lancet

951

911

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Tinnitus is a common medical symptom that can be debilitating. Risk factors include hearing loss, ototoxic medication, head injury, and depression. At presentation, the possibilities of otological disease, anxiety, and depression should be considered. No eff ective drug treatments are available, although much research is underway into mechanisms and possible treatments. Surgical intervention for any otological pathology associated with tinnitus might be eff ective for that condition, but the tinnitus can persist. Available treatments include hearing aids when hearing loss is identifi ed (even mild or unilateral), wide-band sound therapy, and counselling. Cognitive behavioural therapy (CBT) is indicated for some patients, but availability of tinnitus-specifi c CBT in the UK is poor. The evidence base is strongest for a combination of sound therapy and CBT-based counselling, although clinical trials are constrained by the heterogeneity of patients with tinnitus.

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Section: Brain Stimulationmentioning

confidence: 97%

Section: Clinical Trials In Tinnitusmentioning

confidence: 99%

Tinnitus

Baguley¹,

McFerran²,

Hall³

2013

The Lancet

951

911

View full text Add to dashboard Cite

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“…The methodological quality of treatment trials is heterogeneous in the extreme, as emphasized in all available Cochrane meta-analyses that touch on tinnitus (19)(20)(21)(22)(23)(24)(25). Accordingly, efforts are being made to improve quality standards in clinical trials of the treatment of tinnitus (25)(26)(27)(28).…”

Section: Knowledge Basementioning

confidence: 99%

“…Several randomized controlled trials have found evidence for clinical efficacy of rTMS (34). However, the effects of rTMS are slight, the interindividual variability is pronounced, and the duration of the treatment effect is often limited (23,25).…”

Section: Neuromodulatory Treatmentmentioning

confidence: 99%

Chronic Tinnitus

Kreuzer

Vielsmeier²,

Langguth³

2013

Deutsches Ärzteblatt International

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“…The commonly tested and clinically used devices, techniques and therapies for treating tinnitus are: cognitive behavioural therapy (CBT) 8 , which uses relaxation, cognitive restructuring of the thoughts and exposure to exacerbating situations to promote habituation. and is commonly used in moderate to severe cases of tinnitus; tinnitus retraining therapy (TRT) 9 , which is based on a neurophysiological model and consists of a combination of directive counselling and sound therapy in a strict framework and is one of the most commonly used treatment modalities for tinnitus; sound therapy (masking) [10][11][12] , which is built upon the belief that increasing customized extrinsic sound driven activity of the auditory system results in reduced tinnitus; and repetitive transcranial magnetic stimulation (rTMS) 13 , which is a non-invasive method used to induce electrical currents in the brain, and has received increasing attention in recent years for the treatment of many neuropsychiatric disorders, including tinnitus. Although hearing loss is commonly co-morbid with tinnitus, there is no evidence that prescribing hearing aids routinely relieve tinnitus 14 .…”

Section: Introductionmentioning

confidence: 99%

A Randomized, Placebo-Controlled, Double-Blind, Parallel Groups Study Evaluating the Performance and Safety of a Steady State Coherent Biomodulator Patch in the Treatment of Subjective Tinnitus

Ahnblad¹,

Nordkvist²

2017

The International Tinnitus Journal

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Objective: The objectives of this study were to evaluate the performance and safety of an innovative passive light photon driven microscopic biomodulator patch as an alternative medical device for tinnitus relief. Materials and Methods: Eighty-two (82) patients were randomized to receive either an active (biomodulator) patch or a placebo patch, for a 3-week treatment period. Patch performance (evaluated with questionnaires related to tinnitus and quality-of-life) and safety were assessed after 3 weeks of treatment (Week 3) and at a follow-up visit 4-weeks after end of treatment (Week 7). Results: The biomodulator patch was safe and well-tolerated and was efficacious, with significant difference (p < 0.05) between the groups at Week 7; active patch had 30% responders compared to 10% for placebo, measured as a decrease from baseline in at least 2 points in tinnitus annoyance visual analogue scale (VAS, 0-10). Tinnitus handicap inventory (THI, 0-100) improved by mean -16 points significantly (p = 0.0005) for the active responder group, but with no statistically significant changes for the placebo group or between the groups. Well-being questionnaire also improved for the active responder group, but not statistically significant. The placebo responder group did not improve in well-being. Other tinnitus related symptoms did not show significant changes. There was no statistically significant difference in performance between the active (biomodulator) and placebo groups directly at the end of treatment (Week 3). Conclusion: In a cost-risk-benefit rationale according to this study it can be reasonable to recommend the biomodulator patch for treatment of tinnitus. Improvements were shown at Week 7 (4 weeks after the end of treatment period).

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Repetitive transcranial magnetic stimulation for tinnitus

Cited by 94 publications

References 75 publications

Tinnitus

Tinnitus

Chronic Tinnitus

A Randomized, Placebo-Controlled, Double-Blind, Parallel Groups Study Evaluating the Performance and Safety of a Steady State Coherent Biomodulator Patch in the Treatment of Subjective Tinnitus

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