Repetitive transcranial magnetic stimulation combined with cognitive training for the treatment of Alzheimer's disease

Nǵuyen, Jean-Paul; Suarez, Alcira; Kemoun, G.; Meignier, M; Saout, Estelle Le; Damier, Philippe; Nizard, Julien; Lefaucheur, Jean‐Pascal

doi:10.1016/j.neucli.2017.01.001

Cited by 70 publications

(87 citation statements)

References 36 publications

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“…In the first study, improvement in NPI and in Hamilton Rating Scale for Depression (HSRD) was not statistically significant, possibly due to low scores on both instruments at the pretreatment phase. However, Nguyen et al demonstrated significant improvements on scores of the Apathy Inventory, measured as a secondary outcome, in addition to the ADAS‐Cog as the primary outcome. Benefits remained up to 6 months after the end of treatment.…”

Section: Resultsmentioning

confidence: 93%

“…Among these studies, some proposed to investigate BPSD as primary outcomes . Among the remaining studies, BPSD were established as secondary assessments, while cognitive changes were the primary outcome …”

Section: Resultsmentioning

confidence: 99%

“…Two open‐label studies also investigated the efficacy of rTMS for BPSD in AD. Bentwich et al used the multifocal methodology combining rTMS with cognitive training in patients with mild to moderate AD, while Nguyen et al used an adaptation of the same technique across 5 weeks. In the first study, improvement in NPI and in Hamilton Rating Scale for Depression (HSRD) was not statistically significant, possibly due to low scores on both instruments at the pretreatment phase.…”

Section: Resultsmentioning

confidence: 99%

“…Bentwich et al used the multifocal methodology combining rTMS with cognitive training in patients with mild to moderate AD, while Nguyen et al used an adaptation of the same technique across 5 weeks. In the first study, improvement in NPI and in Hamilton Rating Scale for Depression (HSRD) was not statistically significant, possibly due to low scores on both instruments at the pretreatment phase. However, Nguyen et al demonstrated significant improvements on scores of the Apathy Inventory, measured as a secondary outcome, in addition to the ADAS‐Cog as the primary outcome.…”

Section: Resultsmentioning

confidence: 99%

“…Benefits remained up to 6 months after the end of treatment. Results from this study are particularly relevant since apathy responds poorly to available psychopharmacological treatment …”

Section: Resultsmentioning

confidence: 99%

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Noninvasive brain stimulation for behavioural and psychological symptoms of dementia: A systematic review and meta‐analysis

Vacas

Stella

Loureiro

et al. 2018

Int J Geriat Psychiatry

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Background Pharmacological and conventional nonpharmacological treatments for behavioural and psychological symptoms of dementia (BPSD) have only modest efficacy. Furthermore, pharmacotherapy carries the risk of important side effects. Noninvasive brain stimulation (repetitive transcranial magnetic stimulation (TMS) or transcranial direct current stimulation (tDCS)) are valuable and safe for cognitive function in Alzheimer disease (AD). However, there have been few studies, and there is no consensus, regarding the use of these techniques to treat BPSD. Methods We performed a systematic review of the literature and meta‐analysis of studies reporting the effect of rTMS or tDCS on BPSD. Results Seven articles were included: five randomized, controlled clinical trials and two open‐label clinical trials. Five studies investigated the effects of rTMS and two the effects of tDCS. Both studies using tDCS reported no evidence of efficacy on BPSD, while two of the three RCTs using rTMS found statistically significant benefits. In an exploratory meta‐analysis with four of the RCT studies, we did not find evidence of efficacy of noninvasive brain stimulation techniques, with an overall effect of −0.02 (95% CI = −0.90, 0.94; I2 = 85%). However, when we used only the data from the studies that applied rTMS, we found a positive effect on BPSD, with an overall effect of −0.58 (95% CI = −1.02, −0.14; I2 = 0%). With regards to the adverse effects reported, these were mild and not clinically relevant. Conclusions Our results establish a tendency for efficacy of rTMS protocols on BPSD, while corroborating their safety and tolerability, suggesting the need for further research.

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Benefits remained up to 6 months after the end of treatment. Results from this study are particularly relevant since apathy responds poorly to available psychopharmacological treatment …”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Noninvasive brain stimulation for behavioural and psychological symptoms of dementia: A systematic review and meta‐analysis

Vacas

Stella

Loureiro

et al. 2018

Int J Geriat Psychiatry

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Diagnostic criteria for apathy in neurocognitive disorders

Miller¹,

Robert

Ereshefsky³

et al. 2021

Alzheimer's & Dementia

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Introduction:Apathy is common in neurocognitive disorders (NCD) but NCD-specific diagnostic criteria are needed. Methods: The International Society for CNS Clinical Trials Methodology Apathy WorkGroup convened an expert group and sought input from academia, health-care, industry, and regulatory bodies. A modified Delphi methodology was followed, and included an extensive literature review, two surveys, and two meetings at international conferences, culminating in a consensus meeting in 2019. Results:The final criteria reached consensus with more than 80% agreement on all parts and included: limited to people with NCD; symptoms persistent or frequently recurrent over at least 4 weeks, a change from the patient's usual behavior, and including one of the following: diminished initiative, diminished interest, or diminished emotional expression/responsiveness; causing significant functional impairment and not exclusively explained by other etiologies.Discussion: These criteria provide a framework for defining apathy as a unique clinical construct in NCD for diagnosis and further research.

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Neuroprotective Agents

Jain¹

2019

Springer Protocols Handbooks

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Repetitive transcranial magnetic stimulation combined with cognitive training for the treatment of Alzheimer's disease

Cited by 70 publications

References 36 publications

Noninvasive brain stimulation for behavioural and psychological symptoms of dementia: A systematic review and meta‐analysis

Noninvasive brain stimulation for behavioural and psychological symptoms of dementia: A systematic review and meta‐analysis

Diagnostic criteria for apathy in neurocognitive disorders

Neuroprotective Agents

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