Repetitive transcranial magnetic stimulation: a potential therapeutic modality for chronic low back pain

Shafiee, Sajad; Kiabi, Farshad Hasanzadeh; Shafizad, Misagh; Zeydi, Amir Emami

doi:10.3344/kjp.2017.30.1.71

Cited by 5 publications

(3 citation statements)

References 9 publications

(10 reference statements)

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“…In the case of the physical therapy of back pain syndromes, the use of magnetic fields may help to reduce the use of painkillers and the increasingly wider use of antidepressants, which needs further studies [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Chronic-Exposure Low-Frequency Magnetic Fields (Magnetotherapy and Magnetic Stimulation) Influence Serum Serotonin Concentrations in Patients with Low Back Pain—Clinical Observation Study

Woldańska-Okońska

Koszela

2022

IJERPH

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(1) Background: The influence of serotonin on many regulatory mechanisms has not been sufficiently studied. The use of a physical method, assuming the possibility of its action on increasing the concentration of serotonin, may be the direction of therapy limiting the number of antidepressants used. The aim of the research was to study the effects of low-frequency magnetic fields of different characteristics on the circadian profile of serotonin in men with low back pain. (2) Methods: 16 men with back pain syndrome participated in the study. The patients were divided into two groups. In group 1, magnetotherapy (2.9 mT, 40 Hz, square wave, bipolar) was applied at 10.00 a.m. In group 2, the M2P2 magnetic stimulation program of the Viofor JPS device was used. Treatments in each group lasted 3 weeks, 5 days each, with breaks for Saturday and Sunday. The daily serotonin profile was determined the day before the exposure and the day after the last treatment. Blood samples (at night with red light) were collected at 8:00, 12:00, 16:00, 24:00, and 4:00. The patients did not suffer from any chronic or acute disease and were not taking any medications. (3) Results: In group 1, a significant increase in serotonin concentration was observed after 15 treatments at 4:00. In group 2, a significant increase in serotonin concentration was observed at 8:00 after the end of the treatments. In comparison between magnetotherapy and magnetic stimulation, the time points at which differences appeared after the application of serotonin occurred due to the increase in its concentrations after the application of magnetic stimulation. (4) Conclusions: Magnetotherapy and magnetic stimulation, acting in a similar way, increase the concentration of serotonin. Weak magnetic fields work similarly to the stronger ones used in TMS. It is possible to use them in the treatment of mental disorders or other diseases with low serotonin concentrations.

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Section: Discussionmentioning

confidence: 99%

Chronic-Exposure Low-Frequency Magnetic Fields (Magnetotherapy and Magnetic Stimulation) Influence Serum Serotonin Concentrations in Patients with Low Back Pain—Clinical Observation Study

Woldańska-Okońska

Koszela

2022

IJERPH

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“…Various nonoperative interventions are available for nonspecific low back pain treatment, in which lifestyle modification, education, superficial heat, and some nonpharmacological therapy, including exercise and cognitive behavioral therapy, are considered the first-line treatment, while other nonpharmacological therapy and pharmacological therapy, both oral and systemic, are used as second-line or adjunctive treatments [18]. There are several nonpharmacological therapies with promising outcomes for nonspecific low back pain, such as massage [19], acupuncture [20,21], yoga [22], and interdisciplinary rehabilitation, including biopsychosocial rehabilitation [23,24], combined chiropractic [25], therapeutic ultrasound [26], radiofrequency denervation [27], neuroreflexotherapy [28], extracorporeal shockwave therapy [29][30][31], laser therapy [32][33][34], and neuromodulation [35][36][37]. For pharmacological therapies, nonsteroidal anti-inflammatory drugs (NSAIDs) [38][39][40], muscle relaxants [41], intra-articular facet joint injection [42], and herbal medicine, including C. frutescens (Cayenne), H. procumbens, S. alba, S. officinale L., S. chilensis, and lavender essential oil, have shown significant benefits for nonspecific LBP [43].…”

Section: Description Of the Interventionmentioning

confidence: 99%

Nonoperative treatment for pain sensitization in patients with low back pain: protocol for a systematic review

et al. 2022

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Background Low back pain is a disability that occurs worldwide. It is a heterogeneous disorder that affects patients with dominant nociceptive, neuropathic, and central sensitization pain. An important pathophysiology of low back pain involves pain sensitization. Various nonoperative interventions are available for treatment, but there is inconclusive evidence on the effectiveness of these interventions for pain sensitization, leading to arbitrary nonoperative treatments for low back pain. Methods We will conduct a systematic review of RCTs evaluating the effectiveness and safety of nonoperative treatment for pain sensitization in patients with low back pain. The primary outcomes will be static quantitative sensory testing, dynamic quantitative sensory testing, and pain algometry. The secondary outcome will be adverse events. We will search the PubMed, Embase, Scopus, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Cochrane Central Register of Controlled Trials (CENTRAL), and Cochrane Library databases. Two independent authors will screen the titles and abstracts, review full texts, extract data, assess the risk of bias, and evaluate the quality of evidence. We will qualitatively and quantitatively synthesize the results using a random effects model for meta-analysis. Discussion This systematic review aims to provide evidence regarding which treatment, if any, provides the greatest benefit for pain sensitization and safety among patients with low back pain. Evidence synthesized from this systematic review will inform clinical practice and further research. Since there is still a small amount of research, additional studies might need to be conducted in the future. Systematic review registration Submitted to PROSPERO on March 20, 2021, CRD42021244054

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“…Postoperative pain can cause adverse physiological effects such as inadequate depth of breathing and inadequate discharge of respiratory secretions, atelectasis and pulmonary complications, increased heart rate and blood pressure, ileus and prolonged bed rest. Immobility secondary to pain could potentially lead to an increase in incidence of deep vein thrombosis ( 4 – 5 ). In addition, in patients undergoing surgery on the spinal vertebral column, postoperative pain can postpone the onset of walking and physiotherapy, increase hospital stay and cost of surgery and alter the patient's sense of recovery and even adversely affect surgical outcomes ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Preoperative Oral Melatonin on Postoperative Pain after Lumbar Disc Surgery: A Double-Blinded Randomized Clinical Trial

Baradari

Habibi

Aarabi

et al. 2022

Ethiop J Health Sci

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BACKGROUND: Despite advances in surgical and anesthesiology techniques, many patients continue to experience postoperative pain after lumbar disc surgeries. The aim of this study was to investigate the effect of preoperative oral melatonin on the severity of postoperative pain after lumbar laminectomy/discectomy. METHODS: In this double blinded randomized controlled clinical trial 80 patients undergoing an elective mini-open microdiscectomy surgery at Imam Khomeini educational hospital in Sari, Iran, were selected and randomly assigned into one of four groups. Patients in group A, B, C, and D received 3, 5 and 10 mg melatonin or placebo tablets one hour before surgery, respectively. Using the visual analogue scale (VAS) the severity of pain, nausea and vomiting, pruritus, and use of narcotics were assessed immediately after surgery and before leaving the post-anesthesia care unit, 6, 12 and 24 hours postoperatively. RESULTS: In all three groups receiving melatonin at all three different doses, postoperative pain was significantly less than the placebo group (P<0.01). There were no statistically significant differences in postoperative pain level between the three groups receiving melatonin (P>0.05). The amount of opioid received by the patients within 24 hours after surgery had statistically significant differences within the groups (P=0.043, F=2.58). The results of post hoc analysis in terms of postoperative pain intensity showed statistically significant differences between the two groups receiving melatonin at a dose of 5 mg and the placebo group (P= 0.04). No serious side effects reported in four groups. CONCLUSION: The use of oral melatonin with a dose of 5 mg, 1 hour before the surgery as an inexpensive method can effectively reduce pain intensity as well as the amount opioid use after lumbar laminectomy and discectomy.

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Repetitive transcranial magnetic stimulation: a potential therapeutic modality for chronic low back pain

Cited by 5 publications

References 9 publications

Chronic-Exposure Low-Frequency Magnetic Fields (Magnetotherapy and Magnetic Stimulation) Influence Serum Serotonin Concentrations in Patients with Low Back Pain—Clinical Observation Study

Chronic-Exposure Low-Frequency Magnetic Fields (Magnetotherapy and Magnetic Stimulation) Influence Serum Serotonin Concentrations in Patients with Low Back Pain—Clinical Observation Study

Nonoperative treatment for pain sensitization in patients with low back pain: protocol for a systematic review

The Effect of Preoperative Oral Melatonin on Postoperative Pain after Lumbar Disc Surgery: A Double-Blinded Randomized Clinical Trial

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