Repetitive TMS in right sensorimotor areas affects the selection and completion of contralateral movements

Gutierrez-Herrera, Maria; Saevarsson, Styrmir; Huber, Thomas; Hermsdörfer, Joachim; Stadler, Waltraud

doi:10.1016/j.cortex.2017.02.009

Cited by 7 publications

(5 citation statements)

References 52 publications

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“…One of the first TMS studies reported a causal role for the right AG in the control of memory-guided saccades, and showed that the superior part of the right AG is causally involved in maintaining spatial accuracy of remembered target locations of memory-guided saccades (Oyachi and Ohtsuka, 1995). The right AG is crucial for controlling the generation of spontaneous eyeblinks in humans (Nakano, 2017), and during the execution of internally-guided movements (Gutierrez-Herrera et al, 2017). The right AG is critical in planning the reach vector for a specific hand (Vesia et al, 2010), in the early preparation of reaching and grasping movements (Koch et al, 2010), in perceptual (motor) sequence learning (Rosenthal et al, 2009) and in goal-directed hand movements (Baarbe et al, 2021).…”

Section: Agency and Self-processingmentioning

confidence: 99%

Multiple functions of the angular gyrus at high temporal resolution

Seghier

2022

Brain Struct Funct

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Here, the functions of the angular gyrus (AG) are evaluated in the light of current evidence from transcranial magnetic/electric stimulation (TMS/TES) and EEG/MEG studies. 65 TMS/TES and 52 EEG/MEG studies were examined in this review. TMS/TES literature points to a causal role in semantic processing, word and number processing, attention and visual search, self-guided movement, memory, and self-processing.EEG/MEG studies reported AG effects at latencies varying between 32 ms and 800 ms in a wide range of domains, with a high probability to detect an effect at 300-350 ms poststimulus onset. A three-phase unifying model revolving around the process of sensemaking is then suggested: (1) early AG involvement in defining the current context, within the first 200 ms, with a bias toward the right hemisphere; (2) attention reorientation and retrieval of relevant information within 200-500 ms; and (3) cross-modal integration at late latencies with a bias toward the left hemisphere. This sensemaking process can favour accuracy (e.g. for word and number processing) or plausibility (e.g. for comprehension and social cognition). Such functions of the AG depend on the status of other connected regions. The much-debated semantic role is also discussed: (1) there is a strong TMS/TES evidence for a causal semantic role, (2) current EEG/MEG evidence is however weak, but (3) the existing arguments against a semantic role for the AG are not strong. Some outstanding questions for future research are proposed. This review recognizes that cracking the role(s) of the AG in cognition is possible only when its exact contributions within the default mode network are teased apart.

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Section: Agency and Self-processingmentioning

confidence: 99%

Multiple functions of the angular gyrus at high temporal resolution

Seghier

2022

Brain Struct Funct

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“…The functional restoration of the VIS in PD patients can improve the perception and processing of external motor information, thereby improving motor control (Shine et al, 2011). Moreover, visual‐motor feedback can help PD patients improve gait stability and walking speed (Gutierrez‐Herrera et al, 2017). Therefore, the functional restoration of the VIS has a positive effect on PD motor recovery.…”

Section: Discussionmentioning

confidence: 99%

Functional and structural gradients reveal atypical hierarchical organization of Parkinson's disease

Wu,

Ma,

Luo

et al. 2024

Human Brain Mapping

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Parkinson's disease (PD) patients exhibit deficits in primary sensorimotor and higher‐order executive functions. The gradient reflects the functional spectrum in sensorimotor‐associated areas of the brain. We aimed to determine whether the gradient is disrupted in PD patients and how this disruption is associated with treatment outcome. Seventy‐six patients (mean age, 59.2 ± 12.4 years [standard deviation], 44 women) and 34 controls participants (mean age, 58.1 ± 10.0 years [standard deviation], 19 women) were evaluated. We explored functional and structural gradients in PD patients and control participants. Patients were followed during 2 weeks of multidisciplinary intensive rehabilitation therapy (MIRT). The Unified Parkinson's Disease Rating Scale Part III (UPDRS‐III) was administered to patients before and after treatment. We investigated PD‐related alterations in the principal functional and structural gradients. We further used a support vector machine (SVM) and correlation analysis to assess the classification ability and treatment outcomes related to PD gradient alterations, respectively. The gradients showed significant differences between patients and control participants, mainly in somatosensory and visual networks involved in primary function, and higher‐level association networks (dorsal attentional network (DAN) and default mode network (DMN)) related to motor control and execution. On the basis of the combined functional and structural gradient features of these networks, the SVM achieved an accuracy of 91.2% in discriminating patients from control participants. Treatment reduced the gradient difference. The altered gradient exhibited a significant correlation with motor improvement and was mainly distributed across the visual network, DAN and DMN. This study revealed damage to gradients in the brain characterized by sensorimotor and executive control deficits in PD patients. The application of gradient features to neurological disorders could lead to the development of potential diagnostic and treatment markers for PD.

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“…For example, some studies have compared the kinematic properties of right-handed reaches that either involved moving away from the user's body and to the right or away and to the left. This work has found evidence that reaches away from the body and to the right can tend to reach faster speeds (i.e., larger peak velocity; Archambault et al 1999;Berret et al 2021;Knaut et al 2009;Stewart et al 2013;Waters & Wade 2021;Xiao et al 2019) and take less time to complete (i.e., smaller movement times; Archambault et al 1999;Berret et al 2021;Carson et al 1990;Gutierrez-Herrera et al 2017;Kim et al 2011;Stewart et al 2013) than movements away and to the left. Other studies have examined the kinematic properties of reaches that involved moving away from the user's body in depth, compared to reaches that involved moving to the left or right of the starting location at a constant depth.…”

Section: The Effects Of Movement Direction On Reaching Kinematicsmentioning

confidence: 95%

“…Past work has also found that when users perform center-out reaches using their right arm, they can exhibit smaller MT (Archambault et al 1999;Berret et al 2021;Carson et al 1990;Gutierrez-Herrera et al 2017;Kim et al 2011;Stewart et al 2013) and larger v peak (Archambault et al 1999;Berret et al 2021;Stewart et al 2013;Waters & Wade 2021;Xiao et al 2019) when they reach away from their body and to the right, compared to when they reach away from their body and to the left. Further evidence suggests that these patterns may reverse when users instead reach using the left arm, such that users can exhibit larger v peak (Waters and Wade 2021;Xiao et al 2019) when they reach away and to the left than when they reach away and to the right.…”

Section: Away and Contralateral Vs Away And Ipsilateralmentioning

confidence: 97%

“…However, these findings all came from reaching tasks with constraints different from those involved in virtual hand reaching. This includes 3D reaches performed to physical targets (Archambault et al 1999;Carson et al 1990;Gutierrez-Herrera et al 2017;Kim et al 2011;Xiao et al 2019), 2D reaches where the hand could only move in the horizontal plane (Berret et al 2021;Waters and Wade 2021), and reaches performed without visual feedback of the hand (Stewart et al 2013). Therefore, it is not clear if similar patterns may emerge for unconstrained 3D reaching movements performed in VR.…”

Section: Away and Contralateral Vs Away And Ipsilateralmentioning

confidence: 99%

See 1 more Smart Citation

Reaching interactions in virtual reality: the effect of movement direction, hand dominance, and hemispace on the kinematic properties of inward and outward reaches

Clark,

Iskandarani,

Riggs

2024

Virtual Reality

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Recent literature has revealed that when users reach to select objects in VR, they can adapt how they move (i.e., the kinematic properties of their reaches) depending on the: (1) direction they move, (2) hand they use, and (3) side of the body where the movement occurs. In the present work, we took a more detailed look at how kinematic properties of reaching movements performed in VR change as a function of movement direction for reaches performed on each side of the body using each hand. We focused on reaches in 12 different directions that either involved moving inward (toward the body midline) or outward (away from the body midline). Twenty users reached in each direction on both left and right sides of their body, using both their dominant and non-dominant hands. The results provided a fine-grained account of how kinematic properties of virtual hand reaches change as a function of movement direction when users reach on either side of their body using either hand. The findings provide practitioners insights on how to interpret the kinematic properties of reaching behaviors in VR, which has applicability in emerging contexts that include detecting VR usability issues and using VR for stroke rehabilitation.

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Repetitive TMS in right sensorimotor areas affects the selection and completion of contralateral movements

Cited by 7 publications

References 52 publications

Multiple functions of the angular gyrus at high temporal resolution

Multiple functions of the angular gyrus at high temporal resolution

Functional and structural gradients reveal atypical hierarchical organization of Parkinson's disease

Reaching interactions in virtual reality: the effect of movement direction, hand dominance, and hemispace on the kinematic properties of inward and outward reaches

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