Repetitive mild traumatic brain injury alters central and peripheral clock gene expression in the adolescent rat

Sgro, Marissa; Ellens, Susanne; Kodila, Zoe; Christensen, Jennaya; Li, Crystal; Mychasiuk, Richelle; Yamakawa, Glenn R.

doi:10.1016/j.nbscr.2023.100090

Cited by 1 publication

(4 citation statements)

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“…45 This corresponds to preclinical findings that clock gene expression after mTBI is more significantly altered in females than males. 38 Melatonin regulation is also affected after concussion injury. In fact, the entire neuroendocrine and neuroimmune system becomes imbalanced in the acute phase after concussions, including melatonin regulation.…”

Section: Sleep Disturbances and Concussionmentioning

confidence: 99%

“…Sleep disturbances are exceedingly common after concussion injuries, with up to 70% of cases being affected. 38 , 39 These disturbances can include hypersomnia, insomnia, sleep–wake disorders, and sleep apnea. Fatigue is also reported in up to 70% of cases.…”

Section: Sleep Disturbances and Concussionmentioning

confidence: 99%

“… 44 Finally, so-called “clock genes,” that is, genes directly connected to circadian physiology, are shown to be altered in preclinical mTBI models. 38 Interestingly, acute sleep disturbances after concussion appear to be worse in female patients. 45 This corresponds to preclinical findings that clock gene expression after mTBI is more significantly altered in females than males.…”

Section: Sleep Disturbances and Concussionmentioning

confidence: 99%

“… 45 This corresponds to preclinical findings that clock gene expression after mTBI is more significantly altered in females than males. 38 …”

Section: Sleep Disturbances and Concussionmentioning

confidence: 99%

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Circadian therapy interventions for glymphatic dysfunction in concussions injuries: A narrative review

Kureshi¹,

Stowe²,

Francis³

et al. 2023

Science Progress

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There are two primary threats to the brain after concussion. The first is a buildup of neurotoxic proteins in the brain. The second, a partial consequence of the first, is a sustained neuroinflammatory response that may lead to central sensitization and the development of persistent post-concussive symptoms. These threats make neurotoxin clearance a high clinical priority in the acute period after injury. The glymphatic system is the brain's primary mechanism for clearing neurotoxic waste. The glymphatic system is intimately tied to the sleep cycle and circadian dynamics. However, glymphatic dysfunction and sleep disturbances are nearly ubiquitous in the acute period after concussion injury. Because of this, sleep optimization via circadian therapy is a time-sensitive and critical tool in acute concussion management.

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Section: Sleep Disturbances and Concussionmentioning

confidence: 99%

Section: Sleep Disturbances and Concussionmentioning

confidence: 99%