Repetitive magnetic stimulation protects corneal epithelium in a rabbit model of short-term exposure keratopathy

Sher, Ifat; Tzameret, Adi; Goldberg, Zehavit; Bubis, Ettel; Avni-Zauberman, Noa; Kalter‐Leibovici, Ofra; Marcovich, Arie; Simon, Guy Ben; Rotenstreich, Ygal

doi:10.1016/j.jtos.2019.09.009

Cited by 7 publications

(12 citation statements)

References 49 publications

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“…It targets regions in the brain that correspond to the body parts in pain and has been shown to be an effective analgesic, exhibiting more effectiveness at suppressing central rather than peripheral neuropathic corneal pain [68]. This magnetic field stimulates the sensory nerve endings and causes the release of neurotrophins such as nerve growth factor (NGF), assisting in the rehabilitation and healing of the epithelial cells [71].…”

Section: Methods Of Neurostimulationmentioning

confidence: 99%

Neurostimulation for dry eye disease

London

Pincovich

Solomon

2022

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewTo review the neuroanatomy and physiology of the basal and reflex tearing and present the available and developing therapies using the concept of neurostimulation in dry eye disease (DED). Recent findingsThe most prevalent current DED treatments seek to supplement low tear volume and tear components or reduce inflammation. Neurostimulation is a unique approach gaining momentum in recent years, geared toward increasing the production of all basal tear components by stimulating the nerves responsible for producing the various tear components. The neuroanatomy of the lacrimal unit provides several possible access points to stimulate tear production through two arms of the sensory trigeminal nerves. Modes of stimulation include chemical or energy in electrical or magnetic form. Research thus far has shown that neurostimulation can achieve lacrimal, goblet cell, and meibomian gland stimulation. Subjectively it improves symptoms of DED. Clinically, neurostimulation has improved the signs and symptoms of DED by increasing basal tear production and tear volume.

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Section: Methods Of Neurostimulationmentioning

confidence: 99%

Neurostimulation for dry eye disease

London

Pincovich

Solomon

2022

Current Opinion in Allergy &Amp; Clinical Immunology

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“…Interestingly, there are also data supporting the BBB closing effect of NIBS. For instance, in the recent rTMS work on a rabbit eye model, it was shown that the expression of a tight junction protein ZO-1 increased after repetitive magnetic stimulation 78 . The main limitation of this study is that stimulation was applied to the cornea of a rabbit keratopathy model and, thus, targeted corneal epithelial barrier functions, not the BBB.…”

Section: Possible Influence Of Transcranial Magnetic and Electric Sti...mentioning

confidence: 99%

Is blood-brain barrier a probable mediator of non-invasive brain stimulation effects on Alzheimer’s disease?

et al. 2023

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Alzheimer’s disease (AD) is a complex neurodegenerative disease with no existing treatment leading to full recovery. The blood-brain barrier (BBB) breakdown usually precedes the advent of first symptoms in AD and accompanies the progression of the disease. At the same time deliberate BBB opening may be beneficial for drug delivery in AD. Non-invasive brain stimulation (NIBS) techniques, primarily transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), have shown multiple evidence of being able to alleviate symptoms of AD. Currently, TMS/tDCS mechanisms are mostly investigated in terms of their neuronal effects, while their possible non-neuronal effects, including mitigation of the BBB disruption, are less studied. We argue that studies of TMS/tDCS effects on the BBB in AD are necessary to boost the effectiveness of neuromodulation in AD. Moreover, such studies are important considering the safety issues of TMS/tDCS use in the advanced AD stages when the BBB is usually dramatically deteriorated. Here, we elucidate the evidence of NIBS-induced BBB opening and closing in various models from in vitro to humans, and highlight its importance in AD.

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“…Some published translational studies were able to obtain high resolution OCT images of the retina in animal eyes by using commercially available clinical grade OCT instruments equipped with eye tracking to prevent image signal disturbance from animal breathing. Some of these instruments are also equipped to improve OCT image resolution by using an automated software that rescans the same area of the retina and averages multiple images (55,96,97). However, one of the limitations in using the clinical devices is that the automatic layer segmentation procedures developed for the human eye are not applicable to the small rodent eyes.…”

Section: Octmentioning

confidence: 99%

In vivo retinal imaging in translational regenerative research

Sher¹,

Moverman²,

Ketter-Katz³

et al. 2020

Ann Transl Med

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Regenerative translational studies must include a longitudinal assessment of the changes in retinal structure and function that occur as part of the natural history of the disease and those that result from the studied intervention. Traditionally, retinal structural changes have been evaluated by histological analysis which necessitates sacrificing the animals. In this review, we describe key imaging approaches such as fundus imaging, optical coherence tomography (OCT), OCT-angiography, adaptive optics (AO), and confocal scanning laser ophthalmoscopy (cSLO) that enable noninvasive, non-contact, and fast in vivo imaging of the posterior segment. These imaging technologies substantially reduce the number of animals needed and enable progression analysis and longitudinal follow-up in individual animals for accurate assessment of disease natural history, effects of interventions and acute changes. We also describe the benefits and limitations of each technology, as well as outline possible future directions that can be taken in translational retinal imaging studies.

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Repetitive magnetic stimulation protects corneal epithelium in a rabbit model of short-term exposure keratopathy

Cited by 7 publications

References 49 publications

Neurostimulation for dry eye disease

Neurostimulation for dry eye disease

Is blood-brain barrier a probable mediator of non-invasive brain stimulation effects on Alzheimer’s disease?

In vivo retinal imaging in translational regenerative research

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